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Warfarin Sensitivity (CYP2C92, CYP2C93 & VKORC1 Mutation) Test

The Warfarin Sensitivity (CYP2C92, CYP2C93 & VKORC1 Mutation) Test is a genetic test that determines how a person's body metabolizes the anticoagulant medication, warfarin. This helps in personalizing the dosage of the drug to achieve optimal therapeutic effects while minimizing adverse reactions.

Warfarin is a medication often prescribed to prevent blood clots. However, individuals vary significantly in how they respond to this drug, with some requiring higher doses, while others need lower doses. Too much warfarin can cause excessive bleeding, while too little can lead to clotting. This variability can be attributed in part to genetic differences in the enzymes that metabolize warfarin - primarily CYP2C9, and the target protein of warfarin, VKORC1.

  • Test NameWarfarin Sensitivity (CYP2C92, CYP2C93 & VKORC1 Mutation) Test
  • Sample TypeBlood
  • Preparations RequiredNo fasting required. Continue with your normal diet and water consumption unless otherwise instructed by your healthcare provider.
  • Report Time8 Days
Why is the Warfarin Sensitivity test important?

This test is critical for individuals prescribed warfarin because it helps personalize the drug's dosage. This can minimize the risk of side effects and optimize therapeutic benefits.

Is fasting required for this test?

No, fasting is not required for this test. You can continue with your usual diet and water consumption.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

A blood sample is required for this test.

This test should be done before starting warfarin therapy or if you are having difficulty achieving or maintaining therapeutic INR levels.

This test determines how your body metabolizes warfarin, which can influence the dosage you need.

Generally, this test is performed once, as your genetic makeup doesn't change. However, your doctor may suggest repeat testing if your response to warfarin changes unexpectedly.

This is a genetic test and doesn't have "normal" or "abnormal" values. The results will show whether you have certain genetic variants that affect your response to warfarin.

There are no special precautions needed for this test.

Your genetic makeup is the primary factor that could affect the results. Other factors may include your age, weight, diet, and concomitant medications.

You should consult your prescribing doctor, usually a hematologist or cardiologist, if your results show you have warfarin sensitivity.

No specific preparation is required for this test.

Diet (especially vitamin K intake), alcohol consumption, and concomitant medications can modify Warfarin sensitivity.

Genetic factors (CYP2C9 and VKORC1 mutations) and age are non-modifiable factors affecting Warfarin sensitivity.

In conclusion, the Warfarin Sensitivity Test is a crucial diagnostic tool that can significantly enhance the effectiveness and safety of warfarin therapy. By identifying patients who may need lower or higher doses of the drug, healthcare providers can mitigate the risk of severe side effects and ensure that the patient receives the maximum therapeutic benefits. As such, if you are prescribed warfarin, you might benefit from undergoing this test.

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