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Lithium

VDRL / Rapid Plasma Reagin (RPR) Test - Serum

The Venereal Disease Research Laboratory (VDRL) Reflex Treponema pallidum Hemagglutination (TPHA) Confirmation test is a series of blood tests used to detect the presence of antibodies against the bacterium Treponema pallidum, the causative agent of syphilis. Syphilis is a sexually transmitted infection that can cause serious health problems if not treated promptly. Initially, the VDRL test is conducted, which is a non-specific test that can detect any condition causing damage to body tissues. If the VDRL test is positive, it indicates the potential presence of a syphilis infection. To confirm this, the TPHA test is done.

The TPHA test is a more specific test for syphilis and looks for antibodies that are only produced in response to a T. pallidum infection. Hence, a positive VDRL test followed by a positive TPHA test is a reliable indication of a current or past syphilis infection. These tests can help ensure prompt treatment to prevent complications from syphilis.


  • Test NameVDRL / Rapid Plasma Reagin (RPR) Test - Serum
  • Sample TypeBlood
  • Preparations RequiredNo specific preparation is required for this test. Continue with your normal diet and daily activities unless otherwise instructed by your healthcare provider.
  • Report Time4 hours

Why is the VDRL / RPR test ordered?

The test may be ordered if you are showing symptoms of syphilis, as part of routine prenatal screening, or if you are at high risk for the disease due to certain behaviors like unprotected sex, multiple sexual partners, or illicit drug use.

How is the VDRL / RPR test performed?

The test involves taking a blood sample from a vein in your arm. The serum portion of your blood is then tested in a lab for antibodies that may indicate a syphilis infection.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

A positive result indicates that you may have syphilis, but further confirmatory testing is needed as these tests can sometimes give false-positive results.

A negative result typically means you do not have a current syphilis infection. However, if you were recently exposed, you may need to repeat the test as it can take a few weeks for the antibodies to be detectable.

The results are typically available within 1-3 days.

Yes, if you've had syphilis in the past, the antibodies may still be present in your body, and the test could return a positive result.

If you have a positive result, your healthcare provider may order a treponemal test such as FTA-ABS or TP-PA to confirm the diagnosis of syphilis.

This test is quite safe. The main risks are minor and associated with the blood draw, such as slight pain or bruising at the site of the needle insertion.

No, fasting is not necessary before this test.

Yes, continue taking all prescribed medications. If you have any concerns, speak to your healthcare provider.

The frequency of this test depends on your individual risk factors and your healthcare provider's recommendations.

Yes, in fact, this test is typically included in the routine screening tests performed early in pregnancy due to the risk of transmitting syphilis to the baby.

Practicing safe sex, using condoms, and having regular check-ups can help prevent syphilis. If you test positive, it's important to notify your sexual partners so they can also get tested and treated if necessary.

Yes, syphilis is curable with appropriate antibiotic treatment, but it's important to catch it early to prevent long-term complications.

If left untreated, syphilis can progress to its later stages, which can cause serious damage to the heart, brain, and other organs, and can potentially be life-threatening.

While there are home testing kits available for some sexually transmitted diseases, the VDRL/RPR test usually requires a blood sample to be taken by a healthcare professional.

Yes, the VDRL/RPR test can usually be performed on the same day as other lab tests.

Syphilis is transmitted through direct contact with a syphilis sore during vaginal, anal, or oral sex. It can also be passed from an infected mother to her baby during pregnancy.

Currently, there is no vaccine available to prevent syphilis. The most effective methods of prevention are practicing safe sex and having regular check-ups.

The symptoms of syphilis vary depending on the stage of the disease. In its early stage, it may present as a painless sore or rash. Later, it can cause symptoms such as fever, fatigue, weight loss, and aches and pains. If left untreated, it can lead to serious complications affecting the heart, brain, and other organs.

Yes, even after successful treatment, you can be re-infected with syphilis if you have sexual contact with an infected person.

Yes, if left untreated, syphilis can lead to serious health complications such as heart disease, neurological issues, and damage to other organs.

Syphilis antibodies may not be immediately detectable after exposure. If you were recently exposed, it might take a few weeks for the test to turn positive. Therefore, you may need to repeat the test if the first test is negative but you have symptoms or a high suspicion of syphilis.

Yes, untreated syphilis in pregnant women can lead to miscarriage, stillbirth, premature birth, or death of the newborn, as well as severe infections in the baby. It's important to get tested for syphilis during pregnancy to prevent these complications.

If you're allergic to penicillin, your healthcare provider will discuss alternative treatment options with you. It's important to treat syphilis even if you have a penicillin allergy.

VDRL (RPR), SERUM
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