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TRH Stimulation Test (For Prolactin)

TRH Stimulation Test (For Prolactin)

The Thyrotropin-Releasing Hormone (TRH) stimulation test is a diagnostic procedure used to assess the pituitary gland's response to the hormone TRH, specifically looking at the production of the hormone prolactin. The test is performed by injecting TRH into a vein and then measuring the levels of prolactin in the blood at specific intervals.


  • Test Name TRH Stimulation Test (For Prolactin)
  • Sample Type Blood
  • Preparations Required This test is performed under the supervision of a healthcare professional. Avoid eating, drinking, and physical exertion for at least 8 hours before the test.
  • Report Time 6 Hours

The pituitary gland, a tiny organ located at the base of the brain, produces a variety of hormones that regulate many body functions, including growth, reproduction, and metabolism. Among these hormones is prolactin, which plays a crucial role in milk production in women. An abnormal prolactin level can cause various symptoms, such as infertility, irregular menstrual cycles in women, and impotence in men.

Home Sample Collection Process

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Sample Collection by Phlebotomist
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Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

The TRH Stimulation test is a diagnostic procedure used to assess the response of the pituitary gland to Thyrotropin-Releasing Hormone (TRH), with a particular focus on prolactin production.

Your doctor may order a TRH Stimulation test if you have symptoms of prolactin excess, such as unexplained milk production, menstrual irregularities, or fertility problems.

The test is performed by injecting TRH into your vein and then measuring prolactin levels in your blood at specific intervals.

The risks associated with the TRH Stimulation test are minimal but can include discomfort or bruising at the injection site.

Yes, you are advised to avoid eating, drinking, and strenuous physical activity for at least 8 hours before the test.

Typically, results from a TRH Stimulation test are available within 2-3 days.

Your doctor will interpret the results of your TRH Stimulation test. An abnormal response may indicate a problem with your pituitary gland or hypothalamus, a region of the brain that controls the pituitary gland.

Certain medications may affect the results of the TRH Stimulation test. Be sure to inform your healthcare provider of all medications you're currently taking.

Treatment depends on the cause of the high prolactin levels. Medications can often help lower prolactin levels, shrink pituitary tumors, and restore normal hormone function.

If you're pregnant, inform your healthcare provider, as pregnancy can increase prolactin levels, potentially affecting the test's results.

Individuals with symptoms of excess prolactin, such as unexplained milk production, menstrual irregularities, or fertility problems, may be advised to get a TRH Stimulation test.

High prolactin levels can cause various symptoms, including infertility, irregular menstrual cycles in women, and impotence in men.

Low prolactin levels are usually not a cause for concern unless you're nursing. Low levels can make it difficult to produce breast milk.

If your prolactin levels are abnormal, your healthcare provider will recommend the best course of action, which may include medication or lifestyle changes.

Yes, stress can cause a temporary increase in prolactin levels. However, this increase is usually transient and returns to normal once the stress subsides.

Breastfeeding can increase prolactin levels. If you're breastfeeding, let your healthcare provider know as this may affect the interpretation of the test results.

The frequency of the TRH Stimulation test depends on your individual circumstances and is best determined by your healthcare provider.

While the TRH Stimulation test can indicate a problem with the pituitary gland, it cannot directly detect a pituitary tumor. Other tests and imaging studies may be needed for that purpose.

Yes, there are other tests that measure prolactin levels in the blood. However, the TRH Stimulation test provides more detailed information about how the pituitary gland responds to TRH.

If your test results are normal but you're still experiencing symptoms, your healthcare provider will likely recommend further investigation to identify the cause of your symptoms.

TRH stimulation test (For prolactin)
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