TPMT Genotyping for Thyopurine Drugs - Blood - Price | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is required before this test.

₹ 5700

TPMT genotyping is a genetic test that investigates specific variations in the TPMT gene. The TPMT (Thiopurine S-Methyltransferase) gene encodes an enzyme that is crucial in the metabolism of thiopurine medications, including azathioprine, mercaptopurine, and thioguanine. These medications are often used in the treatment of conditions such as leukemia, inflammatory bowel disease, and autoimmune disorders.

Certain genetic variations in the TPMT gene can cause the TPMT enzyme to be produced at lower than normal levels, which can result in slow metabolism of these medications. This may cause toxic levels of the drug to build up in the body, potentially leading to serious side effects such as bone marrow suppression.

By conducting TPMT genotyping before treatment begins, healthcare providers can predict how a patient is likely to respond to thiopurine drugs and can adjust the dosage accordingly to minimize the risk of adverse effects.

Test Name TPMT Genotyping for Thyopurine Drugs - Blood
Sample Type Blood
Preparations Required No specific preparation is required before this test.
Report Time 8 Days
Price in Hyderabad ₹ 5700

What is TPMT Genotyping?

TPMT Genotyping is a genetic test that identifies specific variations in the TPMT gene that can affect how your body metabolizes thiopurine medications.

How is the test performed?

The test is performed on a blood sample that is drawn from a vein in your arm. This sample is then sent to a laboratory where it is examined for specific genetic variations in the TPMT gene.

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What does a "positive" result mean?

A positive result means that one or more genetic variations associated with decreased TPMT enzyme activity were identified. This information can guide your healthcare provider in determining the most appropriate dosage of thiopurine medication for you.

What does a "negative" result mean?

A negative result means that no genetic variations associated with decreased TPMT enzyme activity were identified. In this case, you are considered to have "normal" TPMT activity and are likely to metabolize thiopurine drugs at a normal rate.

Who should get this test?

This test is typically recommended for individuals who are about to start therapy with thiopurine medications. The results can help guide the initial dosing and avoid potential adverse effects.

Can I eat and drink before the test?

Yes, there are no dietary restrictions before this test. You can eat and drink as normal.

Are there any risks associated with this test?

The risks associated with this test are minimal and similar to those of any other blood test. These might include slight pain or bruising at the site where the needle was inserted, but serious complications are rare.

What happens after the test?

After the test, your healthcare provider will review the results and discuss them with you. If your results indicate that you have a variation in your TPMT gene, they may adjust your dosage of thiopurine medication or suggest a different treatment approach.

Can the results of this test change over time?

No, your TPMT genotype is determined by your genes and does not change over time.

Will my insurance cover the cost of this test?

Coverage varies depending on your insurance plan. It's important to check with your insurance provider to understand what costs you may be responsible for.

Can this test predict how effective thiopurine treatment will be for me?

The test can help predict your risk of experiencing side effects from thiopurine medications, but it does not predict the effectiveness of these drugs in treating your condition.

Can I take this test if I am currently on medication?

Yes, you can take this test while on medication. However, always inform your healthcare provider of any medications or supplements you are taking, as they may interfere with the test results.

Can this test be done at home?

No, this test requires a blood draw, which should be performed by a healthcare professional in a clinical setting.

What conditions may affect the results of this test?

Since TPMT genotyping is a genetic test, the results are generally not affected by your current health condition. However, the interpretation of the results in terms of drug response might depend on other factors, such as liver function and the presence of other concurrent medications.

How reliable is this test?

This test is highly reliable for detecting specific genetic variations in the TPMT gene. However, there may be other genetic and non-genetic factors that can also affect how you respond to thiopurine medications.

Are there other tests that can help determine how I will respond to thiopurine drugs?

Yes, in addition to TPMT genotyping, a TPMT enzyme activity test can also provide useful information about how you are likely to respond to thiopurine medications.

What should I do if I have a variant in my TPMT gene?

If you have a variant in your TPMT gene, your healthcare provider may adjust your dose of thiopurine medication or consider a different treatment approach. This decision will depend on various factors, including your overall health, the severity of your condition, and other medications you may be taking.

How can I prepare for the test?

There is no special preparation needed for this test. You can eat and drink normally before the test. If you have any questions or concerns about the test, be sure to discuss them with your healthcare provider.

Is this test only for adults?

No, this test can be performed on individuals of any age, including children. However, the decision to perform this test should be made by a healthcare provider based on an individual's health history and potential benefits and risks.

What are the alternatives if I have low TPMT activity?

If you have a genetic variant that results in low TPMT activity, your healthcare provider may adjust your thiopurine dosage or consider alternative medications. This will depend on the specific condition being treated and other factors related to your overall health.

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