TPMT Enzyme Activity Plasma Test - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is required before this test.

₹ 5900


The TPMT Enzyme Activity test measures the activity level of the Thiopurine Methyl Transferase (TPMT) enzyme in the plasma. This enzyme is crucial for metabolizing thiopurine medications, such as azathioprine, mercaptopurine, and thioguanine, commonly used to treat conditions like autoimmune disorders and leukemia.

Some people have variations in the TPMT gene that cause them to produce too little or too much of this enzyme, which can impact how they metabolize these medications. Low TPMT activity can cause toxic levels of medication to build up in the body, leading to side effects like bone marrow suppression. Conversely, high TPMT activity might result in treatment inefficiency.

The TPMT Enzyme Activity test is typically ordered before initiating therapy with thiopurine medications to help guide dosage and minimize the risk of adverse effects.

Test Name TPMT Enzyme Activity (Thiopurine Methyl Transferase) Plasma
Sample Type Plasma
Preparations Required No specific preparation is required before this test.
Report Time 2 Days
Price in Hyderabad ₹ 5900

What is the TPMT Enzyme Activity test?

This test measures the activity level of the Thiopurine Methyl Transferase enzyme in your plasma. It helps doctors understand how your body will metabolize certain medications and guide appropriate dosage.

How is this test performed?

A healthcare provider will draw a blood sample from a vein in your arm. This blood is then processed to separate the plasma, and the TPMT enzyme activity is measured.

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What does a high TPMT activity mean?

High TPMT activity suggests that your body metabolizes thiopurine drugs rapidly, possibly leading to sub-optimal treatment outcomes as the medication may not stay in your system long enough to be effective.

What does a low TPMT activity mean?

Low TPMT activity suggests that your body metabolizes thiopurine drugs slowly. This could cause the drug to accumulate in your system, leading to potential toxicity and side effects such as bone marrow suppression.

How will this test affect my treatment?

If your TPMT activity is found to be either too high or too low, your healthcare provider may adjust your medication dosage accordingly or consider alternative treatments.

Can I take thiopurine medications if I have low TPMT activity?

It is possible to take thiopurine medications with low TPMT activity, but your healthcare provider may need to adjust your dosage or monitor you more closely for side effects.

Can I eat and drink normally before the test?

Yes, there are no dietary restrictions before this test. You can eat and drink as normal.

What are the risks associated with this test?

The risks associated with this test are minimal and similar to those of any other blood test. You may feel slight pain or bruising at the injection site, but serious complications are rare.

Can the results of this test change over time?

Your TPMT activity is determined by your genes and generally does not change over time. However, certain conditions, like liver disease, can affect TPMT activity.

What should I do after the test?

After the test, you should follow your healthcare provider's instructions. They will discuss your test results with you and explain what they mean for your treatment plan.

Can other medications affect the test results?

Yes, certain medications can affect the results of the TPMT enzyme activity test. Make sure to tell your healthcare provider about all the medications you are taking.

How long does it take to get the test results?

The turnaround time for the test results is typically 3-5 days, but it may vary based on the laboratory.

Is this a genetic test?

No, this test measures the current activity of the TPMT enzyme in your plasma. It does not directly test your genes.

Is this test covered by insurance?

Coverage for this test depends on your insurance plan. Please check with your insurance provider for specific coverage details.

Can I perform this test at home?

No, this test requires a blood draw, which must be performed by a healthcare professional in a clinical setting.

Can I take this test while I'm on medication?

Yes, you can take this test while on medication. However, some medicines might interfere with the test results. It is important to inform your healthcare provider about all the medications and supplements you are currently taking.

Why would my doctor order a TPMT test?

Your doctor may order a TPMT enzyme activity test if you're about to start treatment with thiopurine medications such as azathioprine, mercaptopurine, and thioguanine. The results of this test can help your doctor determine the proper dosage of these medications for you, reducing the risk of adverse effects.

What conditions might affect the results of this test?

Liver disease and other health conditions can potentially affect the results of a TPMT enzyme activity test. Make sure to share your full medical history with your healthcare provider so they can interpret your test results accurately.

Are there alternatives to thiopurine medications if I have low TPMT activity?

Yes, if you have low TPMT activity, your doctor may recommend alternative treatments that are less likely to cause side effects. The appropriate alternative will depend on your specific condition and overall health.

What's the next step after getting the test results?

Your healthcare provider will interpret your test results in the context of your overall health, symptoms, and medical history. If your TPMT activity is either too high or too low, they may adjust your medication dosage or consider alternative treatments. They will discuss these options with you.

To conclude, the TPMT Enzyme Activity test is a critical tool for personalizing treatment with thiopurine drugs. It helps ensure that you receive a dosage that is effective for managing your condition and has the lowest risk of side effects. If you have further questions about this test or what your results might mean, make sure to consult with your healthcare provider.

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