Qualitative PCR-AML-ETO/t(8;21) Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparations are required. However, it's recommended to stay hydrated for the blood draw.

₹ 7500


Acute myeloid leukemia (AML) is a form of cancer that affects the blood and bone marrow. One of the most common chromosomal abnormalities in AML is the t(8;21) translocation, which results in the formation of a fusion gene, AML-ETO. The Qualitative PCR-AML-ETO/t(8;21) test is a crucial diagnostic tool to detect this abnormality, helping doctors understand the nature of the disease and plan an effective treatment strategy.

Test Name Qualitative PCR-AML-ETO/t(8;21)
Sample Type Blood
Preparations Required No specific preparations are required. However, it's recommended to stay hydrated for the blood draw.
Report Time 7 days
Price in Hyderabad ₹ 7500

What is the Qualitative PCR-AML-ETO/t(8;21) test?

This test is a molecular diagnostic method used to detect the presence of the AML-ETO fusion gene, a result of the t(8;21) translocation. This translocation is one of the most common chromosomal abnormalities found in acute myeloid leukemia (AML).

Why do I need this test?

Your doctor might order this test if they suspect you have AML and want to understand the nature of the disease better. Detecting the AML-ETO fusion gene helps them confirm the diagnosis and plan an effective treatment strategy.

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How is this test performed?

The test is performed on a sample of your blood or bone marrow. A healthcare professional will draw the blood sample, while the bone marrow sample is usually obtained via a small surgical procedure.

What does a positive result mean?

A positive result means the AML-ETO fusion gene has been detected in your sample, suggesting the presence of the t(8;21) translocation. This translocation is commonly seen in cases of AML.

What factors can affect the results of this test?

The accuracy of the test can be affected by the quality of the sample and the presence of substances that can interfere with the PCR reaction, such as heparin or hemoglobin.

What happens after the test if I have a positive result?

If the test result is positive, your healthcare provider will discuss the implications with you. This could include further tests and the development of a personalized treatment plan.

How often should I get this test?

The frequency of testing will depend on your specific health condition and your healthcare provider's recommendations. In general, the test might be performed at diagnosis and then periodically to monitor response to treatment and to check for potential relapse.

Can this test detect other forms of leukemia?

The Qualitative PCR-AML-ETO/t(8;21) test specifically detects the AML-ETO fusion gene, which is most commonly associated with AML. It's not typically used to detect other forms of leukemia.

Are there any risks associated with this test?

If a blood sample is used, the risks are minimal and similar to those associated with any other blood test. If a bone marrow sample is required, there are additional risks, including pain, bleeding, and infection at the puncture site, and rarely, damage to the bone.

What is the role of the AML-ETO fusion gene in leukemia?

The AML-ETO fusion gene results from the t(8;21) translocation and is believed to contribute to the development of leukemia by blocking the normal maturation of cells and encouraging their uncontrolled growth.

Who should get this test?

This test is typically performed on individuals suspected of having AML, especially when there is a history of blood disorders or genetic abnormalities. A doctor will often order this test if the symptoms, physical examination, and other lab tests suggest AML.

Can this test be used to monitor treatment progress?

Yes, this test can be useful for monitoring the response to treatment in AML patients with the t(8;21) translocation. After therapy, the disappearance of the AML-ETO fusion gene in the blood or bone marrow is a good indication of successful treatment.

Is this test covered by insurance?

Coverage for this test varies by insurance providers. Please contact your insurance company to understand the coverage policy.

What doctor should I consult if I have abnormal test results?

If the test results are abnormal, you should consult a hematologist or an oncologist, who specialize in blood disorders and cancers, respectively.

How long will I have to wait for my test results?

The turnaround time for results is typically between 7 to 14 days. However, it may vary based on the specific laboratory that analyzes the sample.

AML remains a complex disease, and the Qualitative PCR-AML-ETO/t(8;21) test serves as an essential tool in diagnosing and monitoring AML. The test helps clinicians identify the disease, plan effective treatment strategies, and monitor the patient's response to therapy. Always consult with your healthcare provider for any concerns or questions regarding the test.

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