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Lithium

Protein S Functional Activity

Protein S is a protein that is crucial for blood clot prevention. It acts as a cofactor to Protein C in the inactivation of Factors Va and VIIIa, which are critical for blood clot formation. Thus, a deficit in Protein S levels can lead to excessive clotting or thrombosis.

The Protein S Functional Activity test is a laboratory investigation used to evaluate the functional activity of Protein S in the blood. It is particularly helpful in diagnosing Protein S deficiency, which could be either acquired or inherited. Acquired deficiency can be due to conditions like liver disease, Vitamin K deficiency, or certain medications, while inherited deficiency is a rare genetic disorder.

  • Test NameProtein S Functional Activity
  • Sample TypeBlood
  • Preparations RequiredNo special preparation is needed. However, the patient should inform their doctor about any ongoing medication or supplements, as these can potentially interfere with the test results.
  • Report Time1-3 days
Why is the Protein S Functional Activity test important?

This test is critical in diagnosing Protein S deficiency, which could lead to an increased risk of developing abnormal blood clots. These clots can potentially cause conditions like deep vein thrombosis or stroke.

What is the difference between Protein S antigen and Protein S Functional Activity tests?

While the Protein S antigen test measures the total amount of Protein S in the blood, the Functional Activity test specifically assesses how well the Protein S is working, i.e., its ability to perform its function in preventing blood clotting.

Home Sample Collection Process

1
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2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Frequently Asked Questions

This test is carried out on a blood sample, typically drawn from a vein in the arm.

Abnormal results may indicate a Protein S deficiency, which can increase the risk of forming abnormal blood clots. However, test results should always be interpreted in conjunction with other laboratory tests and clinical information.

No special preparation is necessary. However, inform your doctor about any medications or supplements you are taking as they might affect the results.

The frequency of this test is usually determined by your healthcare provider, based on your overall health, symptoms, and medical history.

Protein S levels can be affected by a variety of factors, including age, pregnancy, oral contraceptive use, certain medications, and medical conditions like liver disease or Vitamin K deficiency.

Normal values may vary between different laboratories. Generally, the normal functional Protein S activity lies in the range of 60% to 140%.

If your test results are abnormal, you should discuss them with your healthcare provider, who may recommend further testing or treatment based on your overall health and medical history.

No, this test requires specialized equipment and trained professionals to perform. It is typically done in a laboratory setting.

Yes, certain medications like oral contraceptives, hormone replacement therapy, and warfarin can affect Protein S levels and hence the test results.

You should consult a hematologist or a vascular medicine specialist if your results are abnormal. They can provide you with a comprehensive interpretation of your results and guide further management.

Treatment for Protein S deficiency is generally focused on preventing or treating blood clots. This may involve using medications like anticoagulants.

Symptoms of Protein S deficiency can vary, but they often involve conditions related to abnormal clotting such as deep vein thrombosis or pulmonary embolism. However, some people may not exhibit any symptoms.

Yes, with appropriate management and monitoring, a person with Protein S deficiency can lead a normal life. Regular consultation with a healthcare provider is crucial.

The Protein S Functional Activity test is a vital investigation tool in the diagnosis of Protein S deficiency, providing valuable insights into the functional efficacy of Protein S in preventing blood clotting. An informed discussion with your healthcare provider will help interpret your results in the context of your overall health, lifestyle, and medical history. Regular monitoring and appropriate interventions can enable individuals with Protein S deficiency to lead healthy lives.

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