Book PML/RARA t(15:17) Gene Rearrangement Quantitative-PCR Test

The PML/RARA t(15:17) Gene Rearrangement Quantitative - PCR test is a genetic test that detects the presence of a specific chromosomal translocation between chromosomes 15 and 17. This translocation results in the fusion of the PML gene on chromosome 15 and the RARA gene on chromosome 17, creating a PML-RARA fusion gene. This fusion gene is a hallmark of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML).

This test is particularly important for individuals suspected of having APL, as the presence of the PML-RARA fusion gene can confirm the diagnosis and guide treatment decisions. It can also be used to monitor the effectiveness of treatment and detect minimal residual disease (MRD) in individuals with known APL.

Test Name PML/RARA t(15:17) Gene Rearrangement Quantitative - PCR
Sample Type Blood or Bone Marrow
Preparations Required No specific preparation is required for this test.
Report Time 4 Days
Price ₹ 5900

Why is the PML/RARA t(15:17) Gene Rearrangement test important?

This test is important because it can confirm the diagnosis of APL, guide treatment decisions, and monitor the effectiveness of treatment. It can also detect MRD, which can indicate a risk of relapse.

Do I need to fast for this test?

No, fasting is not required for this test.

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3. Is there any specific preparation needed for this test?

No specific preparation is needed for this test. However, it's important to inform your doctor about any medications or supplements you're taking as they may affect the test results.

When should I get this test done?

This test may be done if you are suspected of having APL based on your symptoms, physical examination, and other laboratory tests. It may also be done to monitor the effectiveness of treatment and detect MRD if you have known APL.

What information does this test provide?

This test detects the presence of the PML-RARA fusion gene, which is a hallmark of APL. The presence of this fusion gene can confirm the diagnosis of APL, guide treatment decisions, and provide information about the risk of relapse.

How often should I get this test done?

The frequency of this test depends on your individual circumstances and your doctor's recommendations. If you have known APL, your doctor may recommend regular testing to monitor the effectiveness of treatment and detect MRD.

What are the normal values for this test?

Normal results would not detect the PML-RARA fusion gene. However, normal values can vary depending on the specific lab and test used. Your doctor will interpret your results in the context of your overall health and other test results.

Are there any precautions to be taken for this test?

There are no specific precautions for this test. However, it's important to inform your doctor about any medications or supplements you're taking, as they may affect the test results.

What factors can affect the results of this test?

The main factor that can affect the results of this test is the presence of the PML-RARA fusion gene. Other factors, such as certain medications, may also affect the results.

Which doctor should I consult if my test results are abnormal?

If your test results are abnormal, you should consult a hematologist or oncologist. They can provide guidance on the next steps based on your test results and individual circumstances.

Can this test diagnose acute promyelocytic leukemia (APL)?

Yes, this test can confirm the diagnosis of APL. The presence of the PML-RARA fusion gene is a hallmark of this condition.

What does a positive result mean?

A positive result indicates the presence of the PML-RARA fusion gene, which confirms the diagnosis of APL. It can also indicate a risk of relapse in individuals with known APL.

Can lifestyle changes affect the results of this test?

Lifestyle changes cannot affect the presence of the PML-RARA fusion gene in your blood or bone marrow. However, maintaining a healthy lifestyle can help improve your overall health and well-being.

Can medications affect the results of this test?

Certain medications, particularly those used to treat APL, can affect the results of this test. It's important to inform your doctor about all the medications and supplements you're taking.

Can I take this test if I'm pregnant?

Yes, you can take this test if you're pregnant. However, it's important to inform your doctor about your pregnancy as certain conditions can affect pregnancy outcomes.

Can children undergo this test?

Yes, children can undergo this test. However, the interpretation of results may be different in children, and it's important to discuss any concerns with a pediatrician.

Can this test be used to monitor the effectiveness of treatment for APL?

Yes, this test can be used to monitor the effectiveness of treatment for APL. It can also detect MRD, which can indicate a risk of relapse.

Can this test detect other health conditions?

While this test is specifically designed to detect the PML-RARA fusion gene, abnormal results may also suggest other health conditions or complications. Your doctor will interpret the results in the context of your overall health and other test results.

Can this test be used in people with immune system disorders?

Yes, this test can be used in people with immune system disorders. However, the interpretation of results may be different, as these conditions can affect the body's overall immune response.

Can this test be used in people with liver or kidney disease?

Yes, this test can be used in people with liver or kidney disease. However, the interpretation of results may be different, as these conditions can affect the body's overall health status.

In conclusion, the PML/RARA t(15:17) Gene Rearrangement Quantitative - PCR test is a valuable tool for diagnosing and monitoring APL. Always consult with your doctor for personalized advice based on your health status and test results.

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