The MPN Reflex test is a comprehensive genetic analysis that includes mutation screening of JAK2V617F, JAK2 Exon 12, CALR, and MPL, which are known to be associated with MPNs. This testing is important for accurate diagnosis, prognosis, and management of these disorders.
MPNs are a diverse set of blood diseases characterised by an increase in the production of red blood cells, white blood cells, or platelets. The MPN Reflex test analyzes the mutations in the JAK2, CALR, and MPL genes, which are associated with the majority of cases of MPNs. These mutations are involved in cell growth and division, and their abnormal functioning leads to excessive proliferation of cells in the bone marrow. Understanding the genetic basis of MPNs through this test is crucial for precise diagnosis, risk stratification, and guiding therapeutic decisions.
Test NameMyeloproliferative Neoplasms (MPN) Reflex: JAK2V617F, JAK2 Exon 12, CALR, and MPL
Sample Typeblood
Preparations RequiredNo special preparation is required for this test.
Report Timerefer individual test
As one of the best diagnostic services in Hyderabad, Sprint Diagnostics is known for its commitment to providing accurate and reliable results. If you are in Hyderabad and looking for the best MPN Reflex testing near you, Sprint Diagnostics is a trusted option to consider. Taking prompt action, guided by the expertise of specialists, is key to effectively managing MPNs and ensuring the best possible outcomes for individuals facing these blood disorders.
Home Sample Collection Process
1
Book your convenient slot
2
Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Download Reports
Frequently Asked Questions
This test is important for the diagnosis and management of MPNs. It helps in distinguishing between
different types of MPNs, understanding the prognosis, and guiding the choice of treatment.
MPL mutations can activate the thrombopoietin receptor, causing an increased production of blood cells,
particularly platelets. This is associated with certain MPNs like Essential Thrombocythemia and Primary
Myelofibrosis.
The MPN Reflex test is performed using a blood or bone marrow sample. The sample is analyzed in the
laboratory to detect the presence of mutations in the JAK2, CALR, and MPL genes.
No, fasting is not required for this test.
If the results of the MPN Reflex test are abnormal, it is important to consult your doctor to discuss the
implications and to determine the appropriate course of action for management or treatment.
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