Myeloproliferative Neoplasms 3 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No special preparation is required for this test.

₹ 11500

Myeloproliferative Neoplasms (MPNs) comprise a group of blood disorders characterized by the overproduction of blood cells in the bone marrow. The MPN-3 test involves three integral genetic analyses – Karyotyping, BCR-ABL mutation analysis through Fluorescence in situ Hybridization (FISH), and JAK2V617F mutation analysis using Polymerase Chain Reaction (PCR). These analyses are critical for the accurate diagnosis and management of MPNs.

Myeloproliferative Neoplasms (MPNs) encompass a range of disorders marked by an abnormal increase in blood cells produced by the bone marrow. These disorders include Polycythemia Vera, Essential Thrombocythemia, and Chronic Myeloid Leukemia (CML). The MPN-3 test is a diagnostic assay that evaluates the presence of the BCR-ABL fusion gene through FISH, the JAK2V617F mutation through PCR, and examines the chromosomes in the blood or bone marrow cells through Karyotyping. These genetic abnormalities play a significant role in the development of MPNs and are vital markers for diagnosis, risk stratification, and management of the disease.

Test Name Myeloproliferative Neoplasms (MPN) -3: Karyotyping, BCR-ABL Mutation Analysis by FISH and JAK2V617F Mutation Analysis by PCR
Sample Type Blood or Bone Marrow
Preparations Required No special preparation is required for this test.
Report Time 12 Days for cytogeneti cs / 7 Days for PCR
Price in Hyderabad ₹ 11500

What is the MPN-3 test?

The MPN-3 test combines three genetic analyses – Karyotyping, BCR-ABL mutation analysis through FISH, and JAK2V617F mutation analysis via PCR. It is utilized for the diagnosis and management of Myeloproliferative Neoplasms.

Why is the MPN-3 test important?

The MPN-3 test is essential for diagnosing MPNs, especially Chronic Myeloid Leukemia, which is often associated with the BCR-ABL fusion gene. The JAK2V617F mutation is also a characteristic feature in other MPNs, and Karyotyping helps identify chromosomal abnormalities that may be associated with these disorders.

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What does the BCR-ABL fusion gene indicate?

The BCR-ABL fusion gene is created from the joining of portions of the BCR and ABL genes. This fusion gene leads to the production of an abnormal protein that stimulates the bone marrow to produce excessive white blood cells, which is a hallmark of Chronic Myeloid Leukemia (CML).

What does the JAK2V617F mutation indicate?

The JAK2V617F mutation involves a genetic alteration in the JAK2 gene that results in continuous activation of JAK2, a protein involved in cell growth and division. This leads to the overproduction of blood cells, characteristic of certain MPNs.

What is Karyotyping, and why is it important?

Karyotyping is a laboratory technique used to observe the number and structure of chromosomes in cells. In the context of MPNs, Karyotyping can help detect chromosomal abnormalities that might be contributing to the disease.

How is the MPN-3 test performed?

The test requires a blood or bone marrow sample. In the laboratory, FISH is used to detect the BCR-ABL fusion gene, PCR is used to analyze the JAK2 gene for the V617F mutation, and Karyotyping is done to examine the chromosomes.

Is fasting required for the MPN-3 test?

No, fasting is not required for the MPN-3 test.

How often should I get tested?

The frequency of testing should be determined by your doctor based on your health status and any ongoing treatments.

What are the treatment options for MPNs?

Treatment options for MPNs depend on the type and severity and may include medication, blood removal, chemotherapy, or bone marrow transplantation.

Can lifestyle changes help in managing MPNs?

Yes, maintaining a healthy lifestyle, managing stress, and adhering to the treatment plan are important in managing MPNs.

Can MPNs be cured?

Currently, there is no cure for most MPNs, but treatments can help manage symptoms and reduce complications.

What should I do if the test results are abnormal?

If the MPN-3 test results are abnormal, it is important to consult your doctor for further evaluation and discussion of treatment options.

Are there risks associated with the MPN-3 test?

The risks are minimal and mainly related to the blood or bone marrow sample collection, which may cause slight pain or bruising.

Are MPNs hereditary?

Most MPNs are not inherited, but some people may have a genetic predisposition.

Can MPNs evolve into a more aggressive form of cancer?

Yes, MPNs can sometimes evolve into acute leukemia. Regular monitoring and treatment are essential to manage this risk.

Early diagnosis and appropriate management of Myeloproliferative Neoplasms are essential for improving the patient’s quality of life and controlling the disease. The MPN-3 test, which combines Karyotyping, BCR-ABL mutation analysis by FISH, and JAK2V617F mutation analysis by PCR, is a vital tool in diagnosing and managing these disorders. If you or a loved one have been diagnosed with or are experiencing symptoms suggestive of MPN, it is crucial to discuss with your doctor the importance of the MPN-3 test.

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