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Myeloperoxidase (MPO) Stain

Myeloperoxidase (MPO) Stain test is a type of laboratory test used primarily to detect and quantify the presence of myeloperoxidase, an enzyme found in certain types of white blood cells called neutrophils and monocytes. This enzyme plays a critical role in the immune response, helping these cells kill bacteria and other pathogens. The test is commonly performed on a blood sample or a bone marrow sample, but it can also be performed on tissue samples from other parts of the body.

  • Test NameMyeloperoxidase (MPO) Stain
  • Sample TypeTissue/Blood
  • Preparations RequiredThere are no specific instructions for preparation before the test. Continue to take your medications and follow your regular diet unless instructed otherwise by your healthcare provider.
  • Report Time2 Days

The MPO stain is a particular type of stain used in histology and cytology to visualize the presence of myeloperoxidase. It is especially useful in the diagnosis of certain diseases, like acute myeloid leukemia (AML), where the cells typically express high levels of MPO.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

The MPO Stain test is often used to diagnose and monitor diseases that affect the white blood cells, particularly acute myeloid leukemia (AML). The presence or absence of MPO can help differentiate AML from other types of leukemia.

A sample of your blood, bone marrow, or other tissues is collected and sent to a lab. The sample is stained with a special dye that reacts with myeloperoxidase, causing cells containing the enzyme to change color. These stained cells are then examined under a microscope.

If a blood sample is used, you might feel a quick prick or stinging sensation when the needle is inserted into your vein. If a bone marrow sample is used, you'll be given a local anesthetic to numb the area, but you might feel some pressure or discomfort during the procedure.

The risks associated with the MPO Stain test are minimal and mostly related to the sample collection process. For a blood sample, there's a slight risk of bruising, infection, or fainting. For a bone marrow sample, risks include bleeding and infection at the site of the biopsy.

A positive result indicates the presence of MPO in the cells, which can be a sign of AML or another myeloperoxidase-related condition. A negative result could suggest a different type of leukemia or condition. Your healthcare provider will interpret your results in the context of your symptoms and other diagnostic tests.

The turnaround time can vary depending on the lab but typically ranges from 3 to 5 days.

Yes, there are no dietary restrictions before this test.

Yes, continue taking all prescribed medications unless your healthcare provider tells you otherwise.

After the test, you can resume your normal activities. Your healthcare provider will contact you to discuss the results and any next steps.

The frequency of testing depends on your condition. If you're being monitored for AML or another related disease, your healthcare provider will recommend a testing schedule based on your specific needs.

No, the MPO Stain test requires a sample to be taken and processed in a laboratory.

Yes, the MPO Stain test can be used to monitor response to treatment in people with AML or other related conditions.

Your healthcare provider may recommend additional tests to confirm a diagnosis or evaluate your disease, such as a complete blood count (CBC), cytogenetic analysis, or molecular tests.

Yes, certain conditions, such as infections or inflammation, can increase MPO levels and could potentially affect the test results.

The MPO Stain test is generally accurate and reliable, but no test is 100% accurate. False negatives and positives can occur. Your healthcare provider will interpret your test results in conjunction with your symptoms and other diagnostic tests.

No, while a biopsy involves removing a small piece of tissue for examination under a microscope, an MPO Stain test is a type of laboratory analysis performed on that sample. They're different parts of the diagnostic process.

No specific preparation is required for the MPO Stain test. However, if the sample required is a bone marrow biopsy, you may need to prepare for that procedure according to your healthcare provider's instructions.

Yes, this test can be performed on individuals of any age, including children, if required for diagnosis or monitoring of disease.

No, the MPO Stain test isn't typically part of a routine check-up. It is performed when there is a medical reason to suspect a disease that can be identified by the presence of myeloperoxidase in cells.

There are no side effects of the test itself. However, the sample collection process can cause temporary discomfort, and in rare cases, may lead to minor complications like infection or bleeding.

Taking certain medications or having an active infection could potentially affect the results. It's essential to inform your healthcare provider about all medications you're taking and any other health conditions you have.

Myeloperoxidase (MPO) Stain
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