Lab Test

Myeloma IgH Characterization with CD138 Magnetic Bead Enrichment: FISH Analysis for t(4;14) and t(14;16)

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Myeloma IgH Characterization with CD138 Magnetic Bead Enrichment is an advanced diagnostic procedure that uses Fluorescence In Situ Hybridization (FISH) to detect specific chromosomal translocations, t(4;14) and t(14;16), in patients with multiple myeloma. The incorporation of CD138 Magnetic Bead Enrichment significantly enhances the accuracy and sensitivity of the test.

  • Profile Name: Myeloma IgH Characterization with CD138 Magnetic Bead Enrichment: FISH Analysis for t(4;14) and t(14;16)
  • Sample Type: Bone Marrow
  • Preparations Required: No special preparation is needed for this test.
  • Report Time: 9 Days

Multiple myeloma is a type of blood cancer that affects plasma cells, which are crucial for the immune system. In multiple myeloma, these plasma cells multiply uncontrollably and accumulate in the bone marrow, producing abnormal levels of a protein called monoclonal immunoglobulin. The Myeloma IgH Characterization test with CD138 Magnetic Bead Enrichment is designed to detect chromosomal abnormalities, specifically translocations t(4;14) and t(14;16), that are associated with the progression of multiple myeloma.

The addition of CD138 Magnetic Bead Enrichment enhances the test’s sensitivity by isolating and concentrating the plasma cells from the bone marrow sample. CD138 is a marker found on the surface of plasma cells, and magnetic beads coated with antibodies specific for CD138 are used to selectively enrich these cells. This enrichment process increases the probability of detecting chromosomal abnormalities through FISH analysis.

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Frequently Asked Questions

CD138 Magnetic Bead Enrichment is crucial for increasing the accuracy and sensitivity of the FISH analysis by isolating and concentrating the plasma cells. This ensures that the analysis is performed primarily on the relevant cell population, which enhances the detection of chromosomal abnormalities.

Chromosomal translocations are genetic abnormalities where parts of chromosomes break off and reattach to different chromosomes. In multiple myeloma, t(4;14) and t(14;16) translocations are significant, as they are associated with the disease’s progression and can affect the patient's prognosis and treatment plan.

A bone marrow sample is obtained through aspiration. The sample is then subjected to CD138 Magnetic Bead Enrichment to isolate plasma cells. The enriched cells are analyzed using FISH, where fluorescent probes specific for the regions of interest in chromosomes 4, 14, and 16 bind to the DNA, allowing the visualization of translocations under a fluorescence microscope.

The presence of t(4;14) or t(14;16) translocations may indicate a high-risk form of multiple myeloma, which might require more aggressive treatment. Your doctor will consider these results to customize the most effective treatment plan for you.

Bone marrow aspiration can cause some discomfort, but local anesthesia and pain medications are typically used to minimize pain.

This test is usually performed on a bone marrow sample to analyze plasma cells directly. In some cases, a blood sample might be used, but it’s less common and might not be as informative.

Consult your doctor for a detailed understanding of the results and discuss the available treatment options. Your doctor may recommend a specific treatment plan based on the genetic characteristics of your multiple myeloma.

This test is diagnostic and not a treatment. It helps in understanding the genetic makeup of your multiple myeloma, which is crucial for determining an appropriate treatment plan.

While this test is highly specific and sensitive for detecting t(4;14) and t(14;16), it may not identify other genetic abnormalities. Therefore, it is generally used in conjunction with other diagnostic tests.

This test is primarily used for the initial diagnosis and risk stratification of multiple myeloma. Your doctor will advise you if there’s a need for follow-up testing based on your treatment plan and disease progression.

Bone marrow aspiration carries a small risk of infection and bleeding. The procedure itself may cause discomfort, but it is generally safe when performed by experienced professionals.

Coverage for this test varies by insurance providers. It is recommended to consult your insurance company to determine if this test is covered under your policy.

Interpreting the results of FISH analysis should be done by a healthcare professional. Your doctor will explain the significance of the findings and how they impact your prognosis and treatment.

While lifestyle modifications cannot cure multiple myeloma, maintaining a healthy lifestyle can improve overall health and may enhance the effectiveness of treatments. Discuss with your doctor the lifestyle changes that might be beneficial for you.

If you are diagnosed with multiple myeloma or have genetic abnormalities associated with it, it is essential to consult a hematologist or oncologist experienced in treating blood cancers.

Understanding the genetic components of multiple myeloma is crucial in managing the disease effectively. The Myeloma IgH Characterization with CD138 Magnetic Bead Enrichment test is an advanced diagnostic tool that helps in risk stratification and guides the development of personalized treatment plans. It is important to work closely with your doctor to make informed decisions about your healthcare and to consider all available treatment options.

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