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Lab Test

Myeloma IgH Characterization: FISH Analysis for t(4;14) and t(14;16)

Myeloma IgH Characterization is a diagnostic test that employs Fluorescence In Situ Hybridization (FISH) to detect specific chromosomal translocations, t(4;14) and t(14;16), which are associated with multiple myeloma. This test is crucial in the diagnosis and risk stratification of multiple myeloma, as the presence of these translocations has significant implications for the prognosis and treatment approach for the disease.

  • Profile Name: Myeloma IgH Characterization: FISH Analysis for t(4;14) and t(14;16)
  • Sample Type: Bone Marrow
  • Preparations Required: No special preparation is required for this test.
  • Report Time: 5 Days

Multiple myeloma is a type of blood cancer that originates from plasma cells, a type of white blood cell found in the bone marrow. In multiple myeloma, plasma cells multiply abnormally and produce large amounts of an antibody known as immunoglobulin. The Immunoglobulin Heavy chain (IgH) Characterization test is employed to detect chromosomal abnormalities that are common in multiple myeloma. Specifically, this test detects translocations t(4;14) and t(14;16) involving the IgH gene. These translocations are considered high-risk features in multiple myeloma and are associated with a poorer prognosis.

FISH analysis is a highly sensitive and specific technique that uses fluorescent probes to bind to specific DNA sequences on chromosomes. When viewed under a fluorescence microscope, these probes light up, making it possible to visualize and detect genetic abnormalities.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

A chromosomal translocation is a genetic abnormality where a part of one chromosome breaks off and attaches to a different chromosome. In the case of t(4;14) and t(14;16), parts of chromosomes 4 and 16 are translocated to chromosome 14.

FISH analysis uses fluorescent probes that specifically bind to the IgH gene regions on chromosome 14 and the corresponding regions on chromosomes 4 and 16. Under a fluorescence microscope, this binding can be visualized, and the presence of translocations can be detected.

These translocations are considered high-risk features and are associated with a more aggressive form of multiple myeloma. Knowing the presence of these translocations can help guide treatment decisions and prognostic assessments.

Your doctor will use the information from this test to classify your disease into risk categories. High-risk translocations like t(4;14) and t(14;16) may require more aggressive or targeted treatment approaches.

The test requires a bone marrow sample, which may cause some discomfort during the aspiration procedure. Local anesthesia and pain relievers are generally used to minimize discomfort.

No, fasting is not necessary for this test.

This test is typically performed on a bone marrow sample to analyze the plasma cells. In certain cases, a blood sample may be used, but this is less common.

If the test detects t(4;14) or t(14;16), it's important to consult with your doctor to discuss your treatment options and understand the implications for your prognosis.

This test is primarily used for initial risk stratification. Other tests may be used to monitor the progress of the disease over time.

FISH analysis is highly specific but may not detect other genetic abnormalities that don't involve the targeted regions. It's important to consider this test as part of a broader diagnostic evaluation.

There is no special preparation needed for the bone marrow aspiration procedure. However, you should inform your doctor if you are taking any medications or have any allergies.

The results of this test are generally stable, but additional genetic changes can occur as the disease progresses.

Coverage for this test may vary by insurance provider. It’s best to contact your insurance company to determine if this test is covered under your plan.

Knowing your genetic risk can be emotionally challenging, but it's important information for managing your disease effectively. Discuss any concerns with your doctor and consider speaking with a counselor or joining a support group.

It is important to consult a hematologist or oncologist experienced in treating multiple myeloma for proper guidance and management of the disease.

Myeloma IgH Characterization using FISH analysis is a valuable tool in the diagnosis and management of multiple myeloma. Understanding the genetic makeup of your disease can provide critical information for risk stratification and guide personalized treatment plans. Remember, early diagnosis and tailored treatment are key in managing multiple myeloma effectively.

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