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Myeloma Cytogenetics with CD138 Magnetic Bead Enrichment

Myeloma Cytogenetics with CD138 magnetic bead enrichment is an advanced diagnostic technique that combines karyotyping and fluorescence in situ hybridization (FISH) analysis to detect genetic abnormalities in plasma cells, which are involved in multiple myeloma. The inclusion of CD138 magnetic bead enrichment ensures the isolation of plasma cells, enhancing the accuracy and precision of genetic analysis. This test is critical for the diagnosis and management of multiple myeloma, a blood cancer that affects plasma cells.


  • Test NameMyeloma Cytogenetics with CD138 Magnetic Bead Enrichment: Karyotyping and FISH Analysis for del17p, IGH Breakapart, del13q, t(4;14), and t(14;16)
  • Sample TypeBone Marrow
  • Preparations RequiredNo special preparation is required for this test.
  • Report Time12 Days for Karyotype & 7 Days for FISH

Multiple myeloma is a type of blood cancer characterized by the uncontrolled proliferation of plasma cells in the bone marrow. Plasma cells are essential in the immune system as they produce antibodies. In multiple myeloma, genetic abnormalities lead to the production of abnormal plasma cells, which accumulate in the bone marrow, hindering the formation of healthy blood cells. Myeloma Cytogenetics with CD138 magnetic bead enrichment is a specialized test that combines karyotyping and FISH analysis to detect chromosomal abnormalities such as del17p, IGH breakapart, del13q, t(4;14), and t(14;16). CD138 magnetic bead enrichment is used to isolate plasma cells from the sample, ensuring highly accurate analysis.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

CD138 is a protein found on the surface of plasma cells. Magnetic bead enrichment involves using magnetic beads that bind to CD138, allowing for the isolation of plasma cells from a bone marrow sample. This step is essential for increasing the accuracy of chromosomal analysis in multiple myeloma.

Karyotyping involves visualizing the chromosomes in a cell to detect any structural abnormalities. In the context of multiple myeloma, it helps in identifying changes in the number or structure of chromosomes in plasma cells.

Fluorescence In Situ Hybridization (FISH) involves using fluorescent probes to target specific DNA sequences on chromosomes. It is highly sensitive and can detect even small genetic changes, making it a complementary technique to karyotyping.

Del17p refers to the deletion of a part of the short arm of chromosome 17. This genetic abnormality is associated with more aggressive disease and resistance to certain therapies.

IGH breakapart refers to rearrangements involving the immunoglobulin heavy chain gene on chromosome 14. These rearrangements can drive the development and progression of multiple myeloma.

Translocations t(4;14) and t(14;16) are genetic abnormalities involving exchanges between chromosomes 4 and 14, and 14 and 16, respectively. These are associated with high-risk multiple myeloma and can influence treatment decisions.

A bone marrow aspiration procedure is used to collect the sample. This involves inserting a needle into the bone, usually the hip bone, to extract a small amount of bone marrow.

The results can help your doctor to assess the risk level of the disease and customize the treatment plan accordingly. Certain genetic abnormalities may require more aggressive treatments.

Treatment options include chemotherapy, targeted therapy, immunotherapy, stem cell transplantation, and supportive care for managing symptoms and improving quality of life.

There is a small risk of infection, bleeding, or bruising at the needle site. The healthcare team will take precautions to minimize these risks.

Although lifestyle changes can’t cure multiple myeloma, maintaining a healthy lifestyle can help improve overall health and might positively influence the response to treatment.

Currently, multiple myeloma is not considered curable, but it is treatable. Advances in treatment have significantly improved the quality of life and survival rates for patients with multiple myeloma.

Myeloma Cytogenetics with CD138 magnetic bead enrichment is usually done at diagnosis to help establish a treatment plan. Your doctor may also recommend repeat testing if there is a change in your condition or to monitor the response to treatment.

Consult a hematologist or oncologist specializing in blood cancers if you have abnormal results indicative of multiple myeloma.

The prognosis for multiple myeloma varies depending on the chromosomal abnormalities present. Certain abnormalities such as del17p are associated with a poorer prognosis, whereas others may have a more favorable outcome.

Understanding the genetic makeup of multiple myeloma is crucial for personalized treatment strategies. Myeloma Cytogenetics with CD138 magnetic bead enrichment is an advanced diagnostic technique that provides valuable information on the genetic abnormalities in plasma cells. The insights gained through this testing can play a significant role in risk stratification, selecting the most appropriate therapeutic approach, and monitoring the disease. Work closely with your doctor to understand the results and implications for your specific condition.

Myeloma Cytogenetics with CD138 magnetic bead enrichment [ Karyotyping + FISH for del17p + IGH breakapart + del13q + t(4;14) + t(14;16) ]
₹ 20500 Add to Cart
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Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet