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Lab Test

Myeloma Cytogenetics-2: FISH Analysis for del17p, IGH Breakapart, del13q, t(4;14), and t(14;16)

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  • Myeloma Cytogenetics-2: FISH Analysis for del17p, IGH Breakapart, del13q, t(4;14), and t(14;16)
What does IGH breakapart mean?

IGH breakapart refers to rearrangements involving the immunoglobulin heavy chain gene, which is located on chromosome 14. These rearrangements are common in multiple myeloma and can be associated with a more aggressive disease course.


What is the importance of detecting del13q?

Del13q is a deletion of a part of chromosome 13. It is one of the most common cytogenetic abnormalities in multiple myeloma and is associated with a variable prognosis.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

These are specific chromosomal translocations involving exchanges of genetic material between chromosomes 4 and 14 or 14 and 16. They are associated with a poorer prognosis and may influence the choice of treatment.

The sample is collected through a bone marrow aspiration procedure, where a needle is inserted into the bone, typically the hip bone, to extract a small amount of bone marrow.

Identifying specific genetic abnormalities helps your doctor understand the aggressiveness of the disease and predict how it may respond to different treatments. This can be used to tailor a treatment plan to your specific condition.

Treatment options include chemotherapy, targeted therapy, immunotherapy, stem cell transplantation, and supportive care. The presence of certain genetic abnormalities may indicate the need for more aggressive or targeted treatment approaches.

Currently, there is no cure for multiple myeloma, but it is treatable. Advances in treatment have significantly improved survival and quality of life for patients with this disease.

There is a small risk of infection, bleeding, and bruising at the needle site. The healthcare team takes precautions to minimize these risks.

This test is generally performed at diagnosis to assess the genetic characteristics of the disease. It may be repeated if there is a change in your condition or to monitor the response to treatment.

While lifestyle changes cannot cure multiple myeloma, maintaining a healthy lifestyle with a balanced diet and regular exercise can improve overall health and may positively influence response to treatment.

You should consult a hematologist or oncologist who specializes in blood cancers for a detailed evaluation and discussion of treatment options.

The prognosis varies depending on the genetic abnormalities present. For example, patients with del17p or t(4;14) tend to have a poorer prognosis compared to those without these abnormalities.

Yes, the genetic characteristics of multiple myeloma can evolve over time, especially under the pressure of treatment. This is why repeated testing may sometimes be necessary.

Understanding the genetic characteristics of multiple myeloma is crucial for effective management and treatment of the disease. Myeloma Cytogenetics-2 (FISH analysis for del17p, IGH breakapart, del13q, t(4;14), and t(14;16)) provides valuable insights into the genetic makeup of myeloma cells, aiding in risk stratification and personalized treatment planning. Keep an open communication channel with your doctor regarding the results and implications for your specific situation.

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