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Lab Test

MSI Analysis (Microsatellite Stability Index)

The Microsatellite Stability Index (MSI) analysis is a critical diagnostic tool used primarily to determine genetic instability in various forms of cancer. Microsatellites, also known as Short Tandem Repeats (STRs), are small segments of DNA containing repeated base pairs. In some cases, due to DNA mismatch repair deficiency, these repeats may become unstable and increase or decrease in length, a condition known as Microsatellite Instability (MSI).


  • Profile Name: MSI Analysis (Microsatellite Stability Index)
  • Sample Type: Blood
  • Preparations Required: No specific preparation or dietary restrictions are necessary for this test.
  • Report Time: 7 Days

MSI is a characteristic of several types of cancer, including colorectal, endometrial, and gastric cancers, among others. MSI analysis is used to help predict the response to certain cancer treatments, especially immunotherapies, as tumors with high MSI (MSI-H) are often more responsive to these therapies. MSI analysis also plays a role in the detection of Lynch Syndrome, a hereditary condition that increases the risk of various forms of cancer.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

Microsatellite Instability (MSI) is a condition that occurs when the DNA's ability to repair mistakes during DNA replication is impaired, leading to errors in the DNA sequence, specifically in the microsatellites.

MSI Analysis is essential because it helps detect cancers associated with Microsatellite Instability. It is particularly helpful in diagnosing Lynch Syndrome, a genetic condition that significantly increases the risk of colorectal and other cancers.

MSI-H, or Microsatellite Instability-High, indicates a high level of instability in the microsatellites. This condition is often associated with a greater likelihood of response to certain immunotherapies.

Patients diagnosed with colorectal, endometrial, and other cancers should consider this test, especially if they are considering immunotherapy. It's also recommended for individuals with a family history of Lynch Syndrome.

The test is performed using a sample of your tumor tissue, which is analyzed in a laboratory for microsatellite instability.

No fasting is necessary for this test.

As the test uses a tissue sample, any risks are related to the method of obtaining that sample. Your doctor will explain these potential risks to you.

MSI analysis is not a general cancer screening test. It is specifically used to detect cancers associated with microsatellite instability and to diagnose Lynch Syndrome.

While MSI analysis is an important diagnostic tool, additional genetic testing is usually needed to confirm the diagnosis of Lynch Syndrome.

Factors that can affect the results include improper sample collection or handling and technical issues in the lab.

MSI analysis can provide valuable information about your likely response to certain immunotherapies. However, the final treatment decision will also depend on other factors such as your overall health, the type and stage of cancer, and your personal preferences.

If your test results are abnormal, you should consult a medical oncologist or a genetic counselor, depending on the context of the test.

Coverage for MSI Analysis varies depending on the insurance provider and policy. It's best to check with your insurance provider for more information.

It's best to discuss your results with your healthcare provider. They can explain what the results mean in the context of your specific health condition.

No, this test requires a tissue sample which must be collected by a healthcare professional. The sample is then sent to a lab for analysis.

The MSI analysis specifically evaluates the genomic instability within your cells and isn't directly influenced by lifestyle factors. However, a healthier lifestyle can generally contribute to better overall health and possibly a stronger response to treatment.

Generally, the MSI status of a tumor is stable. However, in rare cases, secondary tumors might have a different MSI status than the primary tumor.

MSI analysis is a reliable and established method to detect microsatellite instability. However, like all tests, it may have limitations and should be interpreted in the context of other diagnostic information.

MSI stands for Microsatellite Instability, a condition where the length of microsatellite DNA in tumor cells differs from normal cells. MSS stands for Microsatellite Stable, which means that the length of the microsatellites in tumor cells is the same as in normal cells.

Yes, if you are diagnosed with Lynch syndrome, your blood relatives have a 50% chance of having the condition as well. Therefore, they should consider genetic counseling and testing.

Getting an MSI analysis test is a step towards understanding your body's inner workings at a cellular level. While the prospect of discovering genetic instability can be daunting, it's important to remember that knowledge is power, especially when it comes to managing your health. If you're faced with a high MSI result, don't lose heart. Medical advancements have provided many options for targeted therapies, bringing hope to patients with MSI associated conditions. Armed with the right information, you can work closely with your healthcare provider to make informed decisions about your health journey.

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