MGMT by PCR- on Tissue- Test Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is needed for this test, as the tissue sample will be collected by a healthcare professional during a surgical procedure or biopsy.

₹ 8750


The MGMT by PCR (Temozolomide Resistance) - on Tissue test is a type of genetic test that is primarily used to predict how likely a patient's cancer, specifically glioblastoma, will respond to treatment with the chemotherapy drug temozolomide.

MGMT stands for O6-methylguanine-DNA methyltransferase. It's a gene that produces a protein that can repair certain types of damage to DNA. In some cancers, particularly glioblastoma, the MGMT gene is often "methylated" – meaning it's turned off. When the MGMT gene is turned off, the cancer cells are unable to repair the damage caused by temozolomide, making the drug more effective.

On the other hand, if the MGMT gene is "unmethylated" – meaning it's active – the cancer cells can repair the damage caused by temozolomide, making the drug less effective. This test, which is done on a sample of the cancer tissue, can determine the methylation status of the MGMT gene, providing insights into whether a patient is likely to respond to temozolomide treatment.

Test Name MGMT by PCR (Temozolomide Resistance) - on Tissue
Sample Type Tissue
Preparations Required No specific preparation is needed for this test, as the tissue sample will be collected by a healthcare professional during a surgical procedure or biopsy.
Report Time 12 days
Price in Hyderabad ₹ 8750

How is the test performed?

The test is performed on a sample of the tumor tissue, which is typically obtained during a surgical procedure or biopsy. The tissue is then sent to a laboratory, where technicians will use a technique called polymerase chain reaction (PCR) to amplify the DNA from the MGMT gene and then test it for methylation.

Does this test require any special preparation?

No special preparation is needed for this test. Your healthcare provider will instruct you on any necessary preparations for the biopsy or surgical procedure to obtain the tissue sample.

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Who might need this test?

This test is typically recommended for individuals who have been diagnosed with glioblastoma and are being considered for treatment with temozolomide.

What does it mean if the MGMT gene is methylated?

If the MGMT gene is methylated, it means that it's turned off. This suggests that the cancer cells may not be able to repair the damage caused by temozolomide, making the drug more effective.

What does it mean if the MGMT gene is unmethylated?

If the MGMT gene is unmethylated, it means that it's active. This suggests that the cancer cells may be able to repair the damage caused by temozolomide, making the drug less effective.

Can the results of this test affect my treatment plan?

Yes, the results of this test can significantly influence your treatment plan. If your MGMT gene is found to be methylated, your doctor may consider temozolomide as a suitable treatment option. If it's unmethylated, other treatments may be considered.

How long will it take to get the results?

The turnaround time for this test can vary, but typically, results are available within 7 to 10 days.

What type of doctor should I see if my test results are abnormal?

You should continue your discussions with your oncologist, who is specialized in cancer care and can guide your treatment based on the results of this test.

Can lifestyle changes affect the methylation status of the MGMT gene?

No, the methylation status of the MGMT gene in your tumor cells is not something that you can change through lifestyle modifications.

Is there any risk associated with this test?

The risks associated with this test are primarily related to the biopsy or surgical procedure used to obtain the tissue sample. Your healthcare provider will discuss these with you before the procedure.

Are there any limitations to this test?

The test only provides information about the MGMT gene methylation status in the specific tissue sample tested. This may not reflect the status throughout the entire tumor due to tumor heterogeneity. It is also only one factor among many that can influence how a cancer responds to treatment.

How accurate is this test?

The test is generally accurate in determining the methylation status of the MGMT gene in the sample tested. However, it cannot guarantee whether the cancer will respond to temozolomide, as other factors can also affect drug response.

What other tests might be done in conjunction with this test?

Other tests, such as imaging studies and other molecular tests, might be done in conjunction with this test to provide a more comprehensive view of your cancer and how it may respond to treatment.

Can the results of this test change over time?

The methylation status of the MGMT gene in a tumor can potentially change over time or in response to treatment. However, more research is needed to understand this fully.

Can I do anything to influence the results of this test?

No, the methylation status of the MGMT gene is not something that can be influenced by your actions or lifestyle. It is a characteristic of your tumor.

In summary, the MGMT by PCR (Temozolomide Resistance) - on Tissue test provides important information that can influence the treatment plan for individuals with glioblastoma. By understanding the status of the MGMT gene in the tumor, doctors can make more informed decisions about whether to use temozolomide as part of the treatment plan.

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