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Methyl Malonic Acid Quantitative - Spot Urine

The Methyl Malonic Acid (MMA) Quantitative - Spot Urine test is a laboratory investigation that measures the amount of methyl malonic acid in a sample of your urine. This test is primarily used to help diagnose and monitor certain types of metabolic disorders. It can also provide insights into vitamin B12 deficiency, as increased levels of methyl malonic acid can be a sign of this condition.


Methyl malonic acid is a substance produced in very small amounts by the body. It's part of a process called protein metabolism - the breakdown of proteins in food into amino acids, which can be used by the body for growth and repair. Vitamin B12 is necessary for the proper breakdown of MMA, and in cases of vitamin B12 deficiency, levels of MMA in the body can rise, which is then detected in the urine.

  • Profile Name: Methyl Malonic Acid Quantitative - Spot Urine
  • Sample Type: Urine
  • Preparations Required: No specific fasting or dietary restrictions are required for this test. Continue your usual diet and medication regimen unless advised differently by your healthcare provider.
  • Report Time: 4 days

This test is generally recommended for individuals who have symptoms of a vitamin B12 deficiency or certain metabolic disorders. These symptoms can include fatigue, weakness, a loss of appetite, and neurological changes like numbness and tingling in the hands and feet.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Download Reports
Frequently Asked Questions

The test requires a spot urine sample. You'll need to urinate into a special container. This is then sent to a laboratory for analysis.

No special preparation is needed for this test. However, it's always a good idea to hydrate well and follow your regular diet unless your healthcare provider tells you otherwise.

The test is non-invasive and should not be painful. You may feel slight discomfort from the normal sensation of urinating.

An increased MMA level may indicate a vitamin B12 deficiency or a metabolic disorder. Your doctor will interpret your results in the context of your symptoms and other test results.

The turnaround time can vary, but typically, results are available within 3 to 5 days.

Yes, certain medications can affect MMA levels. These include antibiotics and medications for diabetes. Always inform your healthcare provider about any medications you are taking.

Your doctor might recommend additional tests, such as a complete blood count (CBC), vitamin B12 level, or a homocysteine level, to help determine the cause of the increased MMA.

Yes, this test is suitable for individuals of all ages, including children, if recommended by a healthcare provider.

While the sample collection for this test could theoretically be done at home, it's important that it is conducted under the guidance of a healthcare professional to ensure the sample is properly collected and preserved.

A diet low in vitamin B12 can potentially increase MMA levels. If you follow a vegan or vegetarian diet, which typically contains less vitamin B12, you may have higher MMA levels.

Symptoms may include fatigue, light-headedness, rapid heart rate, easy bruising and bleeding, weight loss, bowel upset, sore tongue, and persistent tingling in the hands and feet.

If your MMA levels are high due to vitamin B12 deficiency, you may be able to lower them by increasing your intake of vitamin B12-rich foods or by taking supplements, but only do this under the guidance of a healthcare provider.

You should consult your primary healthcare provider or a hematologist for abnormal MMA levels. They might refer you to a specialist depending on the cause of the abnormal levels.

Urinary tract infections (UTIs) or other bacterial infections could potentially affect the test results. It's always best to inform your healthcare provider if you have an active infection.

The frequency of the test would depend on your medical condition and your doctor's recommendations. It's often used as a part of a diagnostic process rather than a regular screening.


In conclusion, the Methyl Malonic Acid Quantitative - Spot Urine test is a crucial diagnostic tool used to identify and monitor conditions such as vitamin B12 deficiency and certain metabolic disorders. Being informed about the purpose, procedure, and implications of the test can help patients and caregivers make better health decisions and discuss any concerns with their healthcare provider.

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