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Lambda Light Chain Quantitative, 24 Hours Urine

Lambda Light Chain Quantitative, 24 Hours Urine

The Lambda Light Chain Quantitative test in 24 Hours Urine is a diagnostic test that measures the amount of lambda light chains excreted in the urine over a 24-hour period. Light chains are proteins that are produced by plasma cells in the bone marrow as a part of the immune response. They are components of immunoglobulins (antibodies) that help to fight against infections and diseases. Light chains come in two types – kappa and lambda. In certain medical conditions, particularly disorders of plasma cells such as multiple myeloma, there is an overproduction of light chains. Some of these light chains do not get incorporated into antibodies and are released into the bloodstream as “free” light chains. The kidneys filter out these free light chains, and they are then excreted in the urine. The test is particularly useful in the diagnosis and monitoring of multiple myeloma and other related conditions.

  • Test NameLambda Light Chain Quantitative, 24 Hours Urine
  • Sample TypeUrine
  • Preparations RequiredCollect all urine over a 24-hour period as instructed by the doctor or laboratory. Avoid excessive fluid intake before the test.
  • Report Time2 days
Why is the Lambda Light Chain Quantitative test in 24 Hours Urine done?

The test is used to evaluate the amount of lambda light chains in urine, which can help in the diagnosis and monitoring of plasma cell disorders such as multiple myeloma, AL amyloidosis, and other related diseases.

What do the results mean?

An elevated level of lambda light chains in urine could be indicative of a plasma cell disorder such as multiple myeloma. It is important to interpret this result in conjunction with other laboratory tests and clinical information.

Home Sample Collection Process

1
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Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Frequently Asked Questions

The test requires a 24-hour urine sample. All urine passed in a 24-hour period should be collected in a special container provided by the laboratory. It is crucial to follow the collection instructions carefully.

There is no special preparation needed for the test, but it is important to avoid excessive fluid intake before and during the 24-hour urine collection period.

There are no specific risks associated with this test as it involves the normal collection of urine.

The presence of an excessive amount of lambda light chains in the urine can indicate the overproduction of light chains by plasma cells, which may be a sign of a plasma cell disorder.

Urine lambda light chain levels are often used along with blood tests for lambda light chains and other proteins to provide a more comprehensive view of plasma cell activity and to monitor the course of plasma cell disorders.

Certain medications can potentially affect kidney function and thus the levels of proteins in the urine. It’s important to inform the doctor about any medications you are taking.

Kappa light chains are one of the two types of light chains, the other being lambda. Both types of light chains are part of antibodies produced by plasma cells.

Yes, measuring lambda light chains in the urine can be useful in monitoring the effectiveness of treatment for plasma cell disorders.

Bence Jones proteins are free light chains, either kappa or lambda, present in the urine. The presence of Bence Jones proteins is often associated with multiple myeloma.

No, fasting is not required for this test.

No, high levels of lambda light chains can also be due to other causes such as kidney disease or autoimmune disorders. Further tests are needed for a definite diagnosis.

If you have abnormal Lambda Light Chain levels in urine, it is advisable to consult a hematologist or oncologist.

Laboratories typically define a reference range for normal levels of lambda light chains in urine. However, what is considered normal can vary among different laboratories.

The Lambda Light Chain Quantitative test in 24 Hours Urine is a valuable tool in the diagnosis and management of diseases involving the plasma cells, particularly multiple myeloma. It is important to carefully follow the instructions for collecting a 24-hour urine sample to ensure the accuracy of the results. As with any test, it is important to discuss the results and their implications with your doctor to understand what they mean for your health.

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