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JC/BK Virus - DNA Detection by PCR - Cerebrospinal Fluid (CSF)

JC/BK Virus - DNA Detection by PCR - Cerebrospinal Fluid (CSF)

The JC/BK Virus DNA detection by PCR test is a diagnostic procedure that detects the presence of JC and BK viruses in the cerebrospinal fluid (CSF). The JC virus (JCV) and BK virus (BKV) are human polyomaviruses, and are usually acquired during childhood. They usually remain latent in the body and cause diseases when the immune system is weakened.

The PCR (Polymerase Chain Reaction) test is a very specific and sensitive method that amplifies the DNA of the viruses if present in the sample. As such, it is a critical tool for confirming the diagnosis of diseases caused by these viruses.

The JC virus can cause a rare and often fatal demyelinating disease called progressive multifocal leukoencephalopathy (PML), particularly in people with weakened immune systems, such as HIV/AIDS patients and individuals receiving immunosuppressive therapy. The BK virus, on the other hand, is associated with kidney disease and hemorrhagic cystitis in immunosuppressed individuals, especially in kidney and bone marrow transplant recipients.

  • Test NameJC/BK Virus - DNA Detection by PCR - Cerebrospinal Fluid (CSF)
  • Sample TypeCSF
  • Preparations RequiredNo special preparation is required for this test.
  • Report Time2 Days
What does a positive result mean?

A positive result means that the DNA of the JC or BK virus was detected in the cerebrospinal fluid, which suggests an active infection in the nervous system. This result is generally considered in the context of the patient's symptoms and other test results.

What does a negative result mean?

A negative result means that no JC or BK virus DNA was detected in the sample. This does not necessarily exclude the possibility of an infection, particularly if the sample was taken early in the course of the disease or if the viral load is low.

Home Sample Collection Process

1
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Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Download Reports
Frequently Asked Questions

No, fasting is not required for this test.

This test should be considered if you have symptoms suggestive of diseases caused by these viruses, such as neurological symptoms (for JC virus) or kidney problems (for BK virus), especially if you have a weakened immune system.

The sample is collected by a procedure called a lumbar puncture, or spinal tap, where a small amount of cerebrospinal fluid is extracted from the lower part of your spine.

The lumbar puncture must be carried out by a trained healthcare professional under sterile conditions to minimize the risk of infection. You will be asked to lie on your side or sit up and bend forward to allow better access to the lower spine.

The main factor that can affect the levels is the timing of the sample collection. If the sample is taken too early or too late in the course of the disease, the viral DNA may not be detected.

If symptoms persist despite a negative test result, your doctor may consider other tests to identify the cause of your symptoms. These could include tests for other infections or diseases that have similar symptoms.

If the test results are abnormal, it would be best to consult an infectious disease specialist or a neurologist.

Yes. People with weakened immune systems, such as those with HIV/AIDS, organ transplant recipients, and individuals receiving immunosuppressive therapy, are more likely to develop diseases caused by these viruses.

Currently, there is no vaccine to prevent these viral infections. The best prevention is to maintain a healthy immune system, and for those with a weakened immune system, regular monitoring is recommended to catch any potential infections early.

Treatment mainly involves measures to boost the immune system and, in the case of organ transplant recipients, reducing the dose of immunosuppressive drugs. Antiviral drugs may also be used in some cases.

Yes. Once an active infection is confirmed, this test can be used to monitor the response to treatment and the progression of the disease.

Yes, most people have been exposed to these viruses during their lifetime and carry them in their bodies without any symptoms. Problems occur when the viruses reactivate in people with weakened immune systems.

Although generally safe, a lumbar puncture may cause side effects such as headache, infection, bleeding, or discomfort at the puncture site.

Being aware of the JC/BK Virus - DNA detection by PCR test and understanding its significance can help manage conditions associated with these viruses more effectively. Always consult with your healthcare provider for personalized medical advice and don't hesitate to ask questions to ensure your understanding. Remember, knowledge is the first step towards better health.

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