The JAK2 Exon 12-15 Mutation Analysis is a crucial diagnostic tool designed to identify genetic mutations associated with blood disorders, particularly myeloproliferative neoplasms (MPNs). This intricate test scrutinizes exons 12 to 15 of the Janus kinase 2 (JAK2) gene, a key player in the signaling pathway that regulates blood cell production.
This analysis focuses on detecting abnormalities within these exons, pinpointing mutations that can lead to the production of a modified JAK2 protein with perpetual activation. Such anomalies result in the overproduction of specific blood cells, culminating in the development of MPNs. Notably, this diagnostic approach is instrumental in identifying the specific genetic mutations associated with Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF).
Test NameJAK2 exon 12-15 Mutation
Sample TypeBlood
Preparations RequiredNo specific preparation required prior to the test.
Report Time7 Days
The significance of the JAK2 Exon 12-15 Mutation Analysis goes beyond diagnosis; it plays a pivotal role in understanding the disease's progression and guiding tailored treatment plans. The test provides crucial insights into potential genetic abnormalities for individuals exhibiting symptoms or at risk, aiding in early detection and proactive management.
This analysis becomes even more pivotal if symptoms are observed, such as those associated with a jak2 exon 12 mutation. Recognizing and addressing these symptoms in conjunction with the test results enhances the precision of the diagnosis, allowing for personalized and practical strategies to manage MPNs.
Walk to the nearest Sprint Diagnostic Center in Hyderabad for accurate and fast results.
Home Sample Collection Process
1
Book your convenient slot
2
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
4
Download Reports
Frequently Asked Questions
The JAK2 Exon 12-15 Mutation Analysis test is typically ordered when a healthcare provider suspects a
patient may have a myeloproliferative neoplasm (MPN), especially if the JAK2 V617F mutation test was
negative.
This test requires a blood sample, which is drawn through a needle from a vein in your arm.
No special precautions are necessary before undergoing this test. However, always inform your healthcare
provider about any medications or dietary supplements you're taking.
A positive result indicates the presence of a mutation in the JAK2 gene, specifically in exons 12 to 15.
This could suggest a diagnosis of an MPN.
The test involves a routine blood draw, which carries minimal risks, including slight pain or bruising at
the injection site, fainting, or infection.
JAK2 MUTATION(EXON12), BY RT PCR, EDTA WHOLE BLOOD
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