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Inv 16 (p13q22) Gene Rearrangement Qualitative PCR

Inv 16 (p13q22) Gene Rearrangement Qualitative PCR

The inv(16)(p13q22) Gene Rearrangement Qualitative PCR test is a specialized genetic test used primarily to diagnose a subtype of acute myeloid leukemia (AML) known as AML with inv(16)(p13q22) or t(16;16)(p13;q22). This specific change involves a rearrangement of genetic material between chromosomes 16 and 22.

  • Test NameInv 16 (p13q22) Gene Rearrangement Qualitative PCR
  • Sample TypeBone Marrow or Blood
  • Preparations RequiredNo specific preparation or fasting is required for this test.
  • Report Time7 Days

Why is the inv(16)(p13q22) Gene Rearrangement test important?

The inv(16)(p13q22) test is crucial in the diagnosis and prognosis of certain forms of AML. Patients with this genetic change often respond better to certain treatments and have a more favorable prognosis.

Is fasting required for the inv(16)(p13q22) Gene Rearrangement test?

No, fasting is not required for this test.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

There is no specific preparation required for this test.

This test is often done when a person has symptoms suggestive of AML, such as fatigue, frequent infections, and easy bruising or bleeding, and the doctor wants to confirm the diagnosis and subtype of AML.

This test detects the specific chromosomal rearrangement associated with a subtype of AML. This information can guide treatment decisions and provide information about prognosis.

The frequency of this test will depend on your doctor's recommendations, based on your health condition and treatment response.

In a normal test result, the specific rearrangement of genetic material between chromosomes 16 and 22 is not present.

No special precautions are needed for this test.

The quality of the sample can affect the test results. Therefore, it's important that the test is performed by an experienced technician.

Non-modifiable factors include the inherent characteristics of the leukemia cells, while modifiable factors can include sample quality and laboratory techniques.

In case of an abnormal result, you should consult a hematologist or oncologist.

An abnormal result indicates the presence of the specific chromosomal rearrangement, which is associated with a subtype of AML.

Once the rearrangement is present, it will always be detectable in the leukemia cells. However, effective treatment can reduce the number of these abnormal cells, often to undetectable levels.

This test is highly specific and sensitive for the detection of this specific chromosomal rearrangement.

Treatment options for AML with inv(16)(p13q22) often include chemotherapy and stem cell transplantation. The specific treatment plan will depend on the patient's overall health and other factors. Always remember, this test is just one aspect of the diagnosis and prognosis. It should be used in conjunction with other clinical findings and laboratory tests, and always consult your doctor for a comprehensive treatment approach.

During the test, a healthcare professional will take a sample of your bone marrow or blood. This is then sent to a laboratory, where a method called Polymerase Chain Reaction (PCR) is used to identify the specific gene rearrangement.

The test involves a blood draw or bone marrow extraction. While a blood draw is typically quick and causes minimal discomfort, a bone marrow biopsy can be more uncomfortable. However, local anesthesia is generally used to minimize any pain.

Yes, but always inform your doctor about all medications you are taking, as some could potentially interfere with the test results.

This test specifically looks for a unique gene rearrangement associated with a subtype of AML. It is a specialized test used in the diagnosis and management of this specific type of leukemia.

While lifestyle changes cannot directly affect the genetic features of the leukemia cells, a healthy lifestyle can support overall health, improve tolerance to treatment, and enhance recovery.

Symptoms that might prompt the test include persistent fatigue, frequent infections, unexplained weight loss, easy bruising or bleeding, and pain in the bones or joints.

Other forms of leukemia or myeloproliferative disorders could potentially interfere with the test. Therefore, this test is interpreted in the context of other laboratory and clinical findings.

While the exact causes of AML are not fully understood, it is generally not considered a hereditary condition. The inv(16)(p13q22) rearrangement is typically acquired during a person's lifetime, not inherited from parents.

While you can't control certain risk factors for AML, like age and certain genetic disorders, you can control other risk factors such as exposure to certain chemicals and radiation, smoking, and maintaining a healthy lifestyle.

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