Immunohistochemistry - Cytokeratin 5/6 Test for Lung Cancer, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific patient preparation is required before the test. The healthcare provider will handle all aspects related to the tissue collection, which is usually obtained during a biopsy or a surgical procedure.

₹ 2000


Cytokeratin 5/6 (CK5/6) are types of intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue, which add strength and stability to the cells. They are usually found in the basal cells of the epidermis and are hence also known as basal cell markers.

The Immunohistochemistry - Cytokeratin 5/6 (IHC - CK5/6) test is an immunohistochemical analysis used to detect the presence of CK5/6 in tissue samples. The presence of CK5/6 can help identify certain types of tumors, especially those originating from squamous cells, such as squamous cell carcinomas. Conversely, lack of CK5/6 expression might suggest a non-squamous origin for the tumor.

Test Name IHC - Cytokeratin 5/6 - CK5/6
Sample Type Tissue
Preparations Required No specific patient preparation is required before the test. The healthcare provider will handle all aspects related to the tissue collection, which is usually obtained during a biopsy or a surgical procedure.
Report Time 3 days
Price in Hyderabad ₹ 2000

What does the IHC - CK5/6 test involve?

The IHC - CK5/6 test involves analyzing a tissue sample under a microscope. The tissue is first treated with antibodies that bind to CK5/6 if present. A secondary antibody attached to a color-producing enzyme is then added, causing the tissue to change color if CK5/6 is present.

What does a positive IHC - CK5/6 test mean?

A positive IHC - CK5/6 test indicates the presence of CK5/6 proteins in the examined cells. This could suggest a squamous cell origin for the tumor, but the final diagnosis will depend on the patient's overall clinical picture and results of other tests.

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Is the IHC - CK5/6 test painful?

As the test involves the analysis of a tissue sample, any pain or discomfort would typically be associated with the biopsy or surgical procedure used to collect the sample, not the IHC - CK5/6 test itself.

How accurate is the IHC - CK5/6 test?

The accuracy of the IHC - CK5/6 test largely depends on the quality of the sample and the laboratory techniques used. It is a reliable tool in diagnosing and differentiating between different types of tumors, especially squamous cell carcinomas.

Is a negative IHC - CK5/6 test good news?

Not necessarily. A negative IHC - CK5/6 test means that CK5/6 proteins are not present in the examined cells. While this could rule out certain types of tumors, it does not necessarily indicate a benign condition. Other tests may be needed to establish a definitive diagnosis.

How long does it take to get the results of the IHC - CK5/6 test?

The turnaround time for the IHC - CK5/6 test is typically 5-7 days, but it can vary depending on the laboratory and the complexity of the case.

Can the IHC - CK5/6 test be used to monitor treatment?

The primary purpose of the IHC - CK5/6 test is for diagnostic and prognostic purposes. It is not typically used for monitoring treatment response.

What types of cancer can the IHC - CK5/6 test detect?

The IHC - CK5/6 test is particularly useful in detecting squamous cell carcinomas. However, it may also be used in the diagnosis of other malignancies, including mesothelioma, transitional cell carcinomas, and certain types of adenocarcinomas.

Who orders the IHC - CK5/6 test?

This test is typically ordered by an oncologist, pathologist, or any other medical practitioner involved in the diagnosis and management of cancer.

Can lifestyle factors affect the IHC - CK5/6 test results?

No, lifestyle factors such as diet, exercise, or smoking do not directly influence the results of the IHC - CK5/6 test. This test is based on the expression of CK5/6 proteins in tissue cells, which is not affected by lifestyle.

What does an IHC - CK5/6 test entail?

This test involves an in-depth analysis of a tissue sample. The process starts by treating the sample with antibodies specific to CK5/6, followed by secondary antibodies, which are color-producing enzymes that will bind if CK5/6 is present, leading to a color change in the tissue.

What does it mean if the IHC - CK5/6 test is positive?

A positive result signifies the presence of CK5/6 proteins in the cells being examined. This usually points towards a squamous cell origin of the tumor. However, the final diagnosis depends on the entire clinical scenario and other test outcomes.

Is there any pain associated with the IHC - CK5/6 test?

The IHC - CK5/6 test in itself is not painful. Any discomfort or pain experienced would be from the procedure involved in collecting the tissue sample, such as a biopsy or surgery.

How reliable is the IHC - CK5/6 test?

The reliability of the IHC - CK5/6 test is largely reliant on the quality of the tissue sample and the proficiency of the laboratory. It is considered a reliable diagnostic tool for differentiating between various types of tumors.

Is a negative IHC - CK5/6 test a positive sign?

Not always. A negative result implies that the cells examined do not have CK5/6 proteins. While this could potentially eliminate some types of tumors, it does not automatically translate to a benign condition. Other tests might be necessary for a comprehensive diagnosis.

In conclusion, the Immunohistochemistry - Cytokeratin 5/6 (IHC - CK5/6) test plays a vital role in diagnosing and identifying different types of cancers, especially those of squamous origin. It is essential for patients to understand the implications of this test, and any questions or concerns should be addressed with the healthcare provider. The results of this test should always be evaluated in the context of the patient's overall health and clinical condition.

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