The IHC - Cyclin D1 test, or immunohistochemistry for Cyclin D1, is a diagnostic procedure often employed in pathology to help in the identification and diagnosis of certain types of cancers. Cyclin D1 is a protein involved in regulating the cell cycle, and when overexpressed or mutated, it can contribute to uncontrolled cell growth, a hallmark of cancer.
Cyclin D1 is one of the proteins that regulate the progression of cells through the G1 phase of the cell cycle. It binds to and activates cyclin-dependent kinase 4 (CDK4) or CDK6, allowing the cell to transition from the G1 phase to the S phase. In some cancers, like mantle cell lymphoma, there is an overexpression of Cyclin D1, which causes an unregulated progression of the cell cycle, leading to rapid cell division and cancer growth.
Immunohistochemistry (IHC) is a method that utilizes antibodies to detect specific proteins in cells. The IHC for Cyclin D1 test involves using antibodies that bind to the Cyclin D1 protein, staining the cells that express this protein. This technique is especially useful in diagnosing specific types of cancer.
Test NameIHC - Cyclin D1
Sample TypeTissue
Preparations RequiredNo specific preparation required.
Report Time3 days
What does an IHC - Cyclin D1 test measure?
This test detects the presence and amount of Cyclin D1 protein in tissue samples. Overexpression of Cyclin D1 can be indicative of certain types of cancer, such as mantle cell lymphoma.
Why would I need an IHC - Cyclin D1 test?
Your doctor may recommend this test if you have symptoms or other test results that suggest you may have a type of cancer that commonly overexpresses Cyclin D1. This test can help confirm a diagnosis and guide treatment decisions.
Home Sample Collection Process
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Book your convenient slot
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Sample Collection by Phlebotomist
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Reporting of the sample at lab
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Download Reports
Frequently Asked Questions
The test is performed on a tissue sample, which is usually obtained through a biopsy. The sample is treated with special stains that react with Cyclin D1, and then examined under a microscope.
No specific preparation is required for this test. However, you should inform your doctor about any medications you are currently taking as some drugs may interfere with the test results.
The risks associated with the IHC - Cyclin D1 test are similar to those of the procedure used to obtain the tissue sample. These can include bleeding, infection, and an adverse reaction to anesthesia. You should discuss these potential risks with your doctor.
If the test shows overexpression of Cyclin D1 in your cells, it may suggest the presence of certain types of cancer, such as mantle cell lymphoma. Your doctor will interpret your results in the context of your overall health and other test results.
No, the IHC - Cyclin D1 test is not used for all types of cancer. It is primarily used for certain types of cancer, like mantle cell lymphoma, where overexpression of Cyclin D1 is a common feature.
Yes, you can have this test if you're pregnant or breastfeeding. The test does not involve radiation or harmful substances that could affect pregnancy or breastfeeding.
The interpretation of the test result is done by a pathologist, who will assess the presence and amount of Cyclin D1 in the tissue sample. High levels of Cyclin D1 could indicate certain types of cancer.
If the test is positive, meaning there is an overexpression of Cyclin D1, your doctor will likely recommend additional tests to confirm the diagnosis and determine the best course of treatment.
The frequency of this test depends on your specific situation and your doctor's recommendations. In some cases, it may be repeated to monitor the effectiveness of treatment.
Other tests that may be used in conjunction with or as an alternative to the IHC - Cyclin D1 test include other types of immunohistochemistry tests, molecular genetic tests, and imaging tests.
As with any test, there is a possibility of false positive or false negative results. This could be due to technical issues, how the sample was handled, or other factors. Your doctor will interpret your results in the context of your overall health and other test results.
No, the IHC - Cyclin D1 test requires a tissue sample to be taken, processed, and analyzed in a laboratory. This is not a test that can be done at home.
The results of the test are interpreted by a pathologist, who is a doctor specialized in diagnosing diseases by studying cells and tissues under a microscope.
Understanding the importance and implications of the IHC - Cyclin D1 test can provide valuable insights into one's health status and guide appropriate medical decisions. As always, discuss with your healthcare provider for more personalized information and advice.
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