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Immunoglobulin - IgA Subclasses

Immunoglobulin - IgA Subclasses

Immunoglobulin A (IgA) is a type of antibody that plays a crucial role in the immune function of mucous membranes. The concentration of IgA in the human body is second only to IgG, making it a vital part of our immune system's response to infection. The Immunoglobulin - IgA Subclasses test measures the levels of two subclasses of IgA - IgA1 and IgA2 - in the blood. These subclasses have slightly different roles and locations within the body. Understanding the levels of each can provide important information about an individual's immune system status.

IgA1 is mostly found in the blood, while IgA2 is found in body secretions like tears, saliva, and in the gastrointestinal and respiratory tracts. While both subclasses work together to protect the body against infections, IgA2 is more resistant to degradation by enzymes and is especially important in protecting mucosal surfaces from bacteria and viruses.

  • Test NameImmunoglobulin - IgA Subclasses
  • Sample TypeBlood
  • Preparations RequiredNo special preparation is required for this test. However, it is important to inform your healthcare provider about any medications or supplements you are taking, as these could potentially influence the test results.
  • Report Time3 weeks

Why is the Immunoglobulin - IgA Subclasses test done?

This test is typically done when an individual exhibits recurrent infection, particularly those involving mucosal surfaces such as the respiratory or gastrointestinal tract. It can help diagnose conditions such as Selective IgA Deficiency and Common Variable Immunodeficiency. It's also ordered when an immune deficiency is suspected based on the clinical picture.

Is fasting required for this test?

No, fasting is not typically required for the Immunoglobulin - IgA Subclasses test.

Home Sample Collection Process

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Book your convenient slot
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

This test measures the levels of the two subclasses of Immunoglobulin A, IgA1 and IgA2, in the blood. These values give an insight into the functioning of the immune system, particularly as it relates to mucosal immunity.

The frequency of this test is determined by the healthcare provider based on the individual's clinical condition. It's not a routine test and is typically ordered in response to specific symptoms or clinical indications.

The reference ranges for these immunoglobulins vary between laboratories, but a typical range may be:

  • 1.4 - 4.5 g/L
  • 0.17 - 1.2 g/L
However, only a healthcare provider can interpret these results based on the patient's overall health and specific circumstances.

There are no specific precautions necessary for this test. It's crucial, though, to inform your healthcare provider of any medications, over-the-counter drugs, and supplements you're taking, as certain substances might interfere with the test results.

Various factors can influence the results, including ongoing infections, certain medications, and immune disorders. A complete medical history and current health status should always be shared with your healthcare provider for the most accurate interpretation of your test results.

In case of abnormal results, consultation with a healthcare provider, typically an immunologist or a hematologist, is advised. They can guide you on the next steps based on your specific results and symptoms.

Abnormal levels of IgA subclasses may indicate an immune deficiency. Lower than normal levels could suggest an IgA deficiency, increasing the risk of infections, particularly at mucosal surfaces. Increased levels, on the other hand, could be indicative of chronic infections, autoimmune diseases, or certain types of cancer.

Yes, certain medications can affect the results of an immunoglobulin test. These include corticosteroids, immunosuppressants, and certain chemotherapy drugs. It's essential to inform your healthcare provider about all medications and supplements you're taking.

Yes, the Immunoglobulin - IgA Subclasses test can help identify immune disorders in children. Children with recurrent infections, especially those involving the respiratory or gastrointestinal tract, may be tested for abnormalities in their immunoglobulin levels, including IgA subclasses.

The IgA Subclasses test specifically measures the levels of IgA1 and IgA2, which are key components of the immune system's response at mucosal surfaces. This provides more detailed information about the body's immune response than a general immunoglobulin test.

While maintaining a healthy lifestyle is always beneficial for overall health, lifestyle factors like diet and exercise do not directly influence immunoglobulin levels. However, severe stress and chronic diseases can impact your immune system and potentially affect immunoglobulin levels.

While the test itself does not diagnose a specific disease, the results can provide valuable information that contributes to a diagnosis. Abnormal levels of IgA subclasses may indicate an underlying health issue, like an immune deficiency or an ongoing infection.

The risks associated with this test are minimal and similar to those of a standard blood test. These can include minor pain or bruising at the site of the needle prick. In rare cases, there may be slight bleeding or infection.

Symptoms may vary depending on the specific immunoglobulin that's deficient. In the case of IgA deficiencies, symptoms may include frequent ear or sinus infections, pneumonia, diarrhea, and allergies. More severe immune deficiencies may result in an increased vulnerability to infections and slow recovery from illnesses.

High levels of IgA subclasses could be indicative of certain conditions such as chronic infections, autoimmune diseases, liver diseases, or certain types of cancer. However, your healthcare provider will consider these results along with other diagnostic information to reach a precise diagnosis.

Yes, you can take the test while on medication. However, it's crucial to inform your healthcare provider about all the medications and supplements you're taking, as certain substances might interfere with the test results.

Yes, the Immunoglobulin - IgA Subclasses test is suitable for pregnant women. However, it's essential to inform your healthcare provider if you are pregnant, as certain conditions related to pregnancy might influence the interpretation of the results.

Yes, immunoglobulin levels can fluctuate over time in response to infections, immunizations, and overall changes in health. This is why it's crucial to interpret any changes in the context of a person's overall health status and medical history.

This comprehensive guide to the Immunoglobulin - IgA Subclasses test should help you understand its purpose, process, and significance better. As with all medical investigations, it's important to discuss your results with your healthcare provider who can interpret them in the context of your unique health situation. Remember, this test is a tool that assists in diagnosing and monitoring your health, ensuring you get the most appropriate treatment when needed.

Immunoglobulin - IgA Subclasses
₹ 8000
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  • 4KM from Madhapur
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  • 5KM from Shaikpet