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Immunofixation- Quantitative 24H Urine (Includes Protein Electrophoresis, Immunofixation, Free Light Chains - Kappa & Lambda)

Immunofixation- Quantitative 24H Urine (Includes Protein Electrophoresis, Immunofixation, Free Light Chains - Kappa & Lambda)

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  • Immunofixation- Quantitative 24H Urine (Includes Protein Electrophoresis, Immunofixation, Free Light Chains - Kappa & Lambda)

The 24-hour urine Immunofixation test, including Protein Electrophoresis and detection of Free Light Chains - Kappa & Lambda, is a comprehensive assessment used to identify abnormal proteins, specifically monoclonal proteins (M-proteins), in the urine. These M-proteins are produced in certain diseases like multiple myeloma, a cancer of plasma cells.

During this test, your urine is collected over a 24-hour period, and a series of laboratory procedures, including electrophoresis and immunofixation, are used to separate and identify any abnormal proteins. The light chains, kappa and lambda, are parts of antibodies and their presence in the urine can indicate an overproduction of these proteins due to plasma cell disorders.


  • Test NameImmunofixation- Quantitative 24H Urine (Includes Protein Electrophoresis, Immunofixation, Free Light Chains - Kappa & Lambda)
  • Sample TypeUrine
  • Preparations RequiredNo special preparations are necessary. It is advised, though, to avoid vigorous exercise and certain medications prior to the test if instructed by your healthcare provider.
  • Report Time2 days

Why is this test important?

This test is critical for diagnosing and monitoring conditions like multiple myeloma and other plasma cell disorders. By detecting and identifying abnormal proteins, including M-proteins and free light chains in the urine, this test can help healthcare providers diagnose diseases, assess their severity, and monitor treatment response.

Is fasting required for this test?

No, fasting is not typically required for this test.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Frequently Asked Questions

This test is usually done when symptoms suggest a plasma cell disorder or when a routine blood test reveals abnormal proteins. It might also be conducted periodically to monitor disease progression or treatment response.

This test measures the presence and types of abnormal proteins, including M-proteins and free light chains, in the urine. These proteins are typically not present in the urine of healthy individuals, and their presence may indicate a plasma cell disorder.

The frequency of this test will depend on your healthcare provider's recommendations, the nature of your condition, and how well it's responding to treatment.

In healthy individuals, M-proteins and free light chains are typically not found in the urine. If detected, it may indicate the presence of a plasma cell disorder or other health condition. The interpretation of results should always be done by a healthcare provider considering the overall clinical scenario.

There are no specific precautions for this test. However, it is recommended to avoid intense exercise before the test and to inform your healthcare provider about all the medications, over-the-counter drugs, and dietary supplements you are taking.

Several factors can affect the results of this test, including certain medications, kidney function, and the presence of other proteins in the urine.

If your test results are abnormal, indicating the presence of abnormal proteins in the urine, you should consult with your healthcare provider. They will interpret the results in light of your overall health, symptoms, and medical history, and will suggest the appropriate next steps.

There are minimal risks associated with this test. As it involves the collection of urine, it is non-invasive and does not carry the risks associated with a blood draw.

Yes, certain medications may interfere with the test results. Always inform your healthcare provider about all the medications, over-the-counter drugs, and dietary supplements you are taking.

Yes, apart from plasma cell disorders, this test can also help diagnose and monitor certain kidney conditions, autoimmune disorders, and certain infections.

The detection of M-proteins or free light chains in the urine may indicate a plasma cell disorder or another condition. Your healthcare provider may order further tests to confirm the diagnosis and determine the best course of treatment.

The 24-hour urine immunofixation test, including protein electrophoresis and detection of free light chains, is a highly reliable and sensitive tool for detecting and identifying abnormal proteins in the urine. However, results should always be interpreted in the context of the individual's overall clinical picture.

There's no specific preparation required for this test. It's generally recommended to maintain your usual diet and fluid intake unless instructed otherwise by your healthcare provider.

The test is performed in a clinical laboratory by a trained lab technician under the supervision of a pathologist.

Yes, both men and women can undergo this test if recommended by their healthcare provider, as plasma cell disorders like multiple myeloma can affect both genders.

Once the test is done, your healthcare provider will review the results. If abnormal proteins are detected in the urine, they will discuss the results with you, explain what they mean, and guide you on the next steps, which might include further tests or treatment options.

Lifestyle changes do not directly impact the results of this test. However, maintaining a healthy lifestyle can positively impact overall health, which may aid in managing or recovering from diseases detected by this test.

An abnormal result might be due to several conditions, such as plasma cell disorders, kidney disease, or autoimmune disorders. Certain medications can also cause abnormal results.

A thorough understanding of the 24-hour urine immunofixation test is important for those diagnosed with or suspected of having plasma cell disorders. This test is a valuable tool in the diagnosis, management, and monitoring of such conditions. Always remember, if you have questions or concerns about the test, consult your healthcare provider. They can provide the best advice based on your individual health status.

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