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IHC-TFE3

IHC-TFE3

The IHC-TFE3 diagnostic test plays a significant role in detecting and evaluating rare forms of tumors, particularly renal cell carcinoma (RCC) and alveolar soft part sarcoma (ASPS). The test targets Transcription Factor E3 (TFE3), a protein that when abnormally expressed, can contribute to the development of these tumors.


  • Test Name IHC-TFE3
  • Sample Type Tissue
  • Preparations Required No specific patient preparation is needed for this test. However, ensure you inform your healthcare provider of your current medications or health conditions.
  • Report Time 3 days

TFE3 plays a role in cell growth and proliferation. In certain cases, a gene fusion involving the TFE3 gene can lead to overproduction of the TFE3 protein, driving the growth of tumor cells. The IHC-TFE3 test is designed to identify this overexpression, assisting in the diagnosis of these particular types of cancers.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

The IHC-TFE3 test is crucial for diagnosing specific rare forms of cancer, particularly those associated with abnormal TFE3 expression. It aids in distinguishing these unique tumors from more common types, which is vital for determining the most effective treatment strategy.

No, fasting is not required for this test. However, it's essential to inform your healthcare provider about any medications or supplements you're taking, as they might affect the test results.

The test is generally performed when a patient presents with clinical signs and symptoms suggestive of RCC or ASPS, or if a tumor has features suspicious for a TFE3 gene fusion. Your healthcare provider will guide you based on your specific clinical scenario.

The test identifies the overexpression of the TFE3 protein in tissue samples, indicating a potential TFE3 gene fusion. This information can help diagnose certain types of rare tumors, guiding appropriate treatment.

The frequency of this test depends on the clinical situation and your healthcare provider's recommendation. It is not typically a routinely performed test but is used when specific rare tumors are suspected.

This test typically provides qualitative results, indicating the presence or absence of TFE3 overexpression. Normal results may depend on the specific laboratory performing the test. Your healthcare provider will help you understand your results in the context of your overall health and symptoms.

No special precautions are needed for this test. As with any medical procedure, follow the instructions provided by your healthcare provider.

Factors affecting TFE3 levels are typically non-modifiable, such as genetic alterations leading to a TFE3 gene fusion. There are no known modifiable factors affecting TFE3 levels.

An abnormal test result would typically be discussed with a specialist such as an oncologist or pathologist. They can provide expert interpretation of the test result in the context of your overall health and other diagnostic findings.

You should inform your healthcare provider about any medications or supplements you're taking. While these are unlikely to affect the test, your healthcare provider needs to have all relevant information to interpret your results accurately.

The test itself is not painful. However, the procedure to obtain the tissue sample, such as a biopsy, may cause some discomfort. Your healthcare provider will use local anesthesia to minimize discomfort.

After the test, follow your healthcare provider's instructions for wound care and next steps. If you experience any unusual symptoms or side effects, seek medical attention immediately.

The IHC-TFE3 test is considered accurate for identifying the overexpression of the TFE3 protein in tissue samples. However, the test results should be interpreted alongside other clinical information and diagnostic findings.

The turnaround time for the IHC-TFE3 test typically ranges from 7 to 10 days, but it can vary depending on the specific laboratory and test conditions.

Yes, this test can be performed on patients of all ages if clinically necessary. If you have concerns about your child undergoing this test, it's best to discuss them with your healthcare provider.

Overall, the IHC-TFE3 diagnostic test is a powerful tool in the detection and management of certain rare tumors. By identifying the overexpression of TFE3, this test provides valuable insights that can guide targeted treatment strategies, offering hope to patients diagnosed with these unique forms of cancer. Remember, knowledge is power, especially when navigating the complexities of cancer care.

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