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IHC - Terminal Deoxynucleotide Transferase (TdT)

IHC - Terminal Deoxynucleotide Transferase (TdT)

The IHC - Terminal Deoxynucleotide Transferase (TdT) Diagnostic Test is an essential tool used primarily in hematology, the study of blood and blood-forming organs. TdT is an enzyme found in the nucleus of lymphoid precursor cells, which are the cells that give rise to lymphocytes (a type of white blood cell). Elevated levels of TdT can be indicative of certain types of leukemia and lymphomas.

Immunohistochemistry (IHC) is a method that utilizes antibodies to detect the presence of specific proteins in tissues. In the context of TdT, IHC is used to detect the enzyme in tissue samples, often bone marrow biopsies. This information helps in the diagnosis and categorization of hematological malignancies, particularly acute lymphoblastic leukemia (ALL) and some lymphomas.


  • Test NameIHC - Terminal Deoxynucleotide Transferase (TdT)
  • Sample TypeTissue
  • Preparations RequiredNo special preparation is required for this test. Patients should continue their normal diet and take medications as prescribed.
  • Report Time3 days

Why is the IHC - TdT Diagnostic Test important?

The IHC - TdT test is vital in diagnosing and classifying certain types of leukemia and lymphomas. High levels of TdT are often associated with immature lymphoid cells, which is characteristic of ALL and some lymphomas.

Is fasting required for this test?

No, fasting is not required for this test as it involves testing tissue samples, not blood.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

This test is generally recommended when a patient exhibits symptoms or blood work suggestive of a hematological malignancy, such as unexplained fatigue, weight loss, frequent infections, or abnormal white blood cell counts.

The test detects the presence and levels of Terminal Deoxynucleotide Transferase (TdT) enzyme in tissue samples. High levels of TdT suggest the presence of immature lymphoid cells, which can indicate certain leukemias or lymphomas.

This test is typically performed as part of the initial diagnostic workup for suspected hematological malignancies. Additional testing may be required depending on treatment and response.

Normal values for TdT are typically low or undetectable in healthy individuals. Higher levels may be indicative of a hematological malignancy.

There are no specific precautions needed before this test. Continue with your regular diet and medication unless advised otherwise by your healthcare provider.

TdT levels can be affected by the presence of hematological malignancies and some medications used in chemotherapy.

If the results are abnormal, it is important to discuss them with a hematologist or oncologist. They can provide a proper interpretation and discuss the next steps in diagnosis and treatment.

The risks associated with this test are primarily related to the biopsy procedure, which may cause discomfort, bleeding, or infection.

Yes, certain chemotherapy drugs can affect the levels of TdT.

Yes, the primary use of the IHC - TdT test is in the diagnosis and classification of certain hematological malignancies, particularly acute lymphoblastic leukemia (ALL) and some lymphomas.

A positive test result means that TdT levels are elevated, suggesting the presence of immature lymphoid cells. This is typically indicative of certain types of leukemia or lymphomas. Further investigations will be needed to confirm the diagnosis.

Yes, the IHC - TdT test is usually performed alongside other diagnostic procedures like bone marrow aspiration, complete blood count (CBC), and other specific immunophenotyping tests.

This test is performed by a pathologist in a laboratory setting.

Yes, this test can be done for both men and women if there are suspicions of a hematological malignancy.

The IHC - TdT test is primarily used for diagnosing and classifying certain hematological malignancies. It may be used in other contexts, but such instances are less common.

While lifestyle changes can improve overall health, they do not directly affect TdT levels, which are determined by the presence and activity of immature lymphoid cells.

The test itself is not painful, but the biopsy procedure used to collect the tissue sample may cause some discomfort.

TdT levels can be used to gauge the severity of the disease, which may provide some indication of prognosis. However, individual response to treatment depends on numerous factors, and should be discussed with your healthcare provider.

To conclude, the IHC - Terminal Deoxynucleotide Transferase (TdT) Diagnostic Test is a crucial investigation tool in diagnosing and managing hematological malignancies. Always remember to discuss your test results with your healthcare provider. Understanding your results and their implications can greatly enhance your journey towards effective treatment and improved health.

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