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Immunohistochemistry (IHC) -Neuron-Specific Enolase (NSE)

The Neuron-Specific Enolase (NSE) Immunohistochemistry (IHC) test is a vital diagnostic tool performed on tissue samples, primarily used in the evaluation and differentiation of certain types of tumors, including neuroendocrine tumors and small cell lung cancer. NSE is a specific form of the enzyme enolase, present predominantly in neurons and cells of neuroendocrine origin. The NSE IHC test uses antibodies specific to NSE to identify its presence in tissue samples, providing valuable insights into the patient's condition.

Identification of NSE helps in distinguishing between different tumor types, thereby influencing the choice of therapeutic strategy. While NSE is chiefly found in neuronal and neuroendocrine cells, its elevated levels might indicate other pathologies, enhancing the scope of this diagnostic test.

  • Test NameImmunohistochemistry (IHC) -Neuron-Specific Enolase (NSE)
  • Sample TypeTissue
  • Preparations RequiredNo specific preparation is required for this test.
  • Report Time3 days

Why is the NSE IHC test important?

The NSE IHC test plays a critical role in diagnosing and differentiating neuroendocrine tumors, small cell lung cancer, and other conditions. It helps clinicians to determine the most appropriate treatment path.

Is fasting required for the NSE IHC test?

No, fasting is not required for this test. The test is performed on tissue samples, typically obtained through a biopsy or surgical procedure.

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Reporting of the sample at lab
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Frequently Asked Questions

There's no specific preparation required for this test as the tissue sample is usually collected by a healthcare professional during a biopsy or surgery.

This test is generally recommended when there's suspicion of a neuroendocrine tumor or small cell lung cancer, typically following imaging studies or if symptoms point towards these conditions.

The test measures the presence or absence of NSE, an enzyme found predominantly in neurons and cells of neuroendocrine origin. It aids in distinguishing between different types of tumors.

The frequency of this test depends on your doctor's advice and is generally conducted during the diagnostic process or when monitoring the treatment response.

The NSE IHC test is interpretative, based on the detection of NSE, rather than a numerical value. A positive result signifies the presence of NSE, which might be indicative of specific tumor types.

As this test is performed on tissue samples, the main precautions pertain to the biopsy or surgical procedure used to collect the sample.

NSE levels can be influenced by the presence of certain types of neuroendocrine tumors or small cell lung cancer. There are no known modifiable factors affecting NSE expression.

If your NSE IHC test results are abnormal, consult with an oncologist. They can guide you on the implications of the results and the next course of action.

While NSE is primarily associated with neuroendocrine tumors and small cell lung cancer, its elevation may also be seen in other pathologies. Thus, the test result should be interpreted alongside other clinical and diagnostic information.

NSE is predominantly found in neurons and cells of neuroendocrine origin. However, it can be detected in other body tissues under certain pathological conditions.

There are no specific medication restrictions for this test. But you should always inform your healthcare provider about any ongoing medications before any surgical or biopsy procedure.

No, this test requires a tissue sample which is usually obtained via a biopsy or surgical procedure, hence it needs to be performed in a medical setting by a healthcare professional.

The NSE IHC test is highly specific; however, it should be interpreted along with other diagnostic tests and clinical findings for a comprehensive evaluation.

Navigating through the complex domain of cancer diagnosis can be daunting. Yet, diagnostic tests like the NSE IHC play a crucial role in illuminating the path ahead. They assist in providing an accurate diagnosis, thereby guiding the appropriate treatment strategy. Remember, in this journey, you are never alone - your healthcare team is with you every step of the way, providing guidance and support.

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