IHC - Microsatellite Instability for Colorectal Carcinoma MSH-2 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is necessary for this test.

₹ 2000


The ImmunoHistoChemistry (IHC) - Microsatellite Instability (MSI) for Colorectal Carcinoma MSH-2 test is a specific diagnostic tool that aids in the diagnosis and management of colorectal cancer. It is a molecular method that measures the presence and activity of a protein called MSH-2, which is involved in DNA repair. The loss of this protein due to mutations is a hallmark of colorectal cancer and other cancers associated with Lynch Syndrome.

Colorectal cancer is the third most common type of cancer globally, and understanding its underlying genetic causes can significantly improve the management and prognosis of the disease. The MSH-2 protein is a part of the mismatch repair system that corrects errors in the DNA replication process. Mutations in the MSH-2 gene can lead to Microsatellite Instability, a condition marked by genetic hypermutability that significantly increases the risk of developing colorectal cancer.

Test Name IHC - Microsatellite Instability for Colorectal Carcinoma MSH-2
Sample Type Tissue
Preparations Required No specific preparation is necessary for this test.
Report Time 4 days
Price in Hyderabad ₹ 2000

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What is the purpose of the IHC - MSI for Colorectal Carcinoma MSH-2 test?

The IHC - MSI for Colorectal Carcinoma MSH-2 test is used to detect the absence or malfunctioning of the MSH-2 protein in colorectal cancer tissues. The absence of this protein indicates the presence of Microsatellite Instability (MSI), which is a risk factor for colorectal cancer and other Lynch syndrome- related cancers.

Is fasting required for this test?

No, fasting is not required for this test.

How often should I get tested?

The frequency of this test depends on your doctor's advice. It is usually performed when colorectal cancer or Lynch syndrome is suspected.

What do the test results mean?

A normal result shows the presence of the MSH-2 protein, indicating that the DNA mismatch repair system is likely functioning correctly. An abnormal result, characterized by the absence or malfunctioning of the MSH-2 protein, suggests the presence of MSI and an increased risk of colorectal cancer.

Can this test diagnose other types of cancer?

Yes. While primarily used for diagnosing colorectal cancer, this test can also help diagnose other cancers associated with Lynch syndrome, such as endometrial cancer.

What precautions should I take before this test?

No specific precautions are necessary for this test. However, make sure to inform your doctor about any medications or supplements you are currently taking.

What factors can affect the levels of MSH-2 protein?

Factors that can affect MSH-2 protein levels include genetic mutations, age, and certain lifestyle factors like diet and exposure to environmental toxins.

What are the normal values for this test?

Normal values indicate the presence and normal functioning of the MSH-2 protein. However, the exact values may vary depending on the specific laboratory guidelines.

What kind of doctor should I consult if my test results are abnormal?

If your test results are abnormal, you should consult an oncologist or a genetic counselor for further advice and treatment options.

Are there any specific preparations for this test?

No specific preparations are needed for this test.

Can certain medications affect the test results?

Certain medications might interfere with the test results. Therefore, it's important to inform your doctor about all medications, supplements, and vitamins you're currently taking before the test.

Can lifestyle modifications affect the levels of MSH-2 protein?

While lifestyle modifications can generally support overall health, they cannot significantly alter the genetic mutations that affect MSH-2 protein levels.

What happens if MSH-2 protein levels are low?

Low levels of MSH-2 protein suggest the presence of MSI, which is associated with an increased risk of developing colorectal cancer and other Lynch syndrome-related cancers.

Is this test suitable for people of all ages?

Yes, this test is suitable for individuals of all ages. However, it is most commonly recommended for adults with a personal or family history of colorectal cancer or Lynch syndrome.

Can this test detect cancer at an early stage?

While this test cannot directly detect cancer, it can identify the presence of MSI, a condition that significantly increases the risk of developing colorectal cancer. Early detection of MSI can lead to early diagnosis and treatment of the disease.

The IHC - MSI for Colorectal Carcinoma MSH-2 test is a valuable tool in the early detection and management of colorectal cancer. By identifying the presence of Microsatellite Instability, it can provide important information that helps shape a patient's treatment plan and surveillance strategy. Early detection is key to successful treatment and improving survival rates. If you have a personal or family history of colorectal cancer or Lynch syndrome, consult your doctor about the potential benefits of this test.

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