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IHC - Granzyme B

IHC - Granzyme B

In the field of immunohistochemistry (IHC), the Granzyme B marker stands out as a vital tool in diagnosing and monitoring various medical conditions. Immunohistochemistry involves the process of selectively identifying antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. This technique has played a fundamental role in the diagnostic pathology of numerous diseases.

  • Test Name IHC - Granzyme B
  • Sample Type Tissue
  • Preparations Required No specific instructions; the test is performed on a tissue sample usually obtained through a biopsy.
  • Report Time 3 days
  • Price in Hyderabad

Granzyme B is a protein that plays a crucial role in the immune response, specifically, the body's cytotoxic response that leads to the death of infected or cancerous cells. In IHC, the Granzyme B test is essential in identifying cells involved in this immune response. This information can be pivotal in diagnosing diseases such as lymphomas, viral infections, and autoimmune disorders.

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Frequently Asked Questions

The IHC - Granzyme B test is a diagnostic procedure that identifies the presence of Granzyme B in a tissue sample. This protein is typically present in cytotoxic T cells and natural killer (NK) cells that participate in immune responses.

This test is critical as it helps identify cells involved in the immune response against infected or abnormal cells. It's especially useful in diagnosing certain types of lymphomas and other conditions where these immune cells are active.

The test is performed on a tissue sample, usually obtained through a biopsy. The tissue is treated with an antibody that binds to Granzyme B. If Granzyme B is present, it will bind to the antibody and can be detected under a microscope.

A positive result means that Granzyme B is present in the tissue sample, suggesting an active immune response. Depending on other clinical information and test results, this could indicate an infection, an autoimmune disorder, or a form of lymphoma.

No, fasting is not required for this test as it is performed on a tissue sample.

The frequency of this test depends on the clinical situation. It's not a routine test but is ordered by your doctor based on your symptoms and other diagnostic results.

In normal tissues, Granzyme B is typically present in low amounts. However, the interpretation of "normal" can vary depending on the clinical context and should be discussed with your doctor.

There are no specific precautions related to the test itself. However, you should follow your doctor's instructions regarding the biopsy procedure if a tissue sample is being taken.

You should discuss any abnormal results with the doctor who ordered the test, which could be an immunologist, hematologist, or oncologist, depending on the context.

The quality of the tissue sample, the technique used in the laboratory, and the experience of the pathologist interpreting the results can affect the accuracy of the test.

The risks associated with the IHC - Granzyme B test are mainly related to the biopsy procedure used to obtain the tissue sample. This may include pain, bleeding, or infection at the biopsy site.

No specific medications are known to affect the result of this test. However, medications affecting the immune system could potentially influence the levels of Granzyme B.

Yes, Granzyme B is primarily present in cytotoxic T cells and natural killer cells, which play a critical role in the immune response.

Yes, the IHC - Granzyme B test is a reliable tool in identifying the presence of Granzyme B in tissue samples. However, its interpretation should always be in the context of other clinical information.

No, this test requires a tissue sample, which needs to be collected by a healthcare professional, and then processed in a laboratory. The IHC - Granzyme B test is a powerful tool in modern medicine, contributing significantly to the understanding and diagnosis of various diseases. Although it might seem complex, the test's role is relatively simple - to identify a protein crucial to our immune response. Although not a routine test, it plays an essential part in diagnosing and monitoring certain medical conditions. Always consult with your healthcare provider for any concerns or questions related to this test and the associated medical conditions.

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