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IHC - GLYPICAN-3 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

GPC3 is a member of the glypican family of heparan sulfate proteoglycans. It is attached to the cell surface through a glycosylphosphatidylinositol anchor. Though it plays a crucial role in cell growth and division, abnormalities in its expression have been linked to several types of cancers, including hepatocellular carcinoma (HCC), melanoma, and pediatric yolk sac tumors.

The IHC test for Glypican-3 (GPC3) involves staining a tissue sample with special antibodies that bind to GPC3 if present. It is commonly used to assist in the diagnosis of certain types of cancer, specifically hepatocellular carcinoma (HCC), a common form of liver cancer. If GPC3 is detected, it indicates a likelihood of HCC. However, it's important to remember that this is only one part of a comprehensive diagnostic process.

  • Test Name: IHC - GLYPICAN-3
  • Sample Type: Tissue
  • Preparations Required: No fasting or specific preparation is required
  • Report Time: 3 days

  • Home Sample Collection Process

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    Book your convenient slot
    Sample Collection by Phlebotomist
    Sample Collection by Phlebotomist
    Reporting of the sample at lab
    Reporting of the sample at lab
    Download Reports
    Download Reports
    Frequently Asked Questions

    The GPC3 test helps identify the presence of certain types of cancers, particularly hepatocellular carcinoma (HCC). Its results can inform treatment planning and provide important prognostic information.

    No, fasting is not necessary before this test.

    There is no specific preparation needed for this test. However, be sure to inform your doctor about any medications you are currently taking and any allergies you have.

    The test is usually done when a person has signs and symptoms suggestive of liver cancer or if imaging studies reveal a mass in the liver.

    The test identifies the presence of the GPC3 protein in tissue samples. Overexpression of GPC3 is often seen in certain cancers, including hepatocellular carcinoma.

    This test is not typically done on a routine basis. It is performed when there is a clinical suspicion of certain types of cancers.

    In healthy tissues, GPC3 expression is generally low or undetectable. Increased levels are often associated with specific types of cancer.

    There are no specific precautions related to this test.

    The level of GPC3 can be affected by certain medical conditions, such as liver cirrhosis or hepatitis, and certain types of cancer.

    You should consult an oncologist if your GPC3 test result is abnormal. An oncologist is a doctor who specializes in treating cancer.

    The GPC3 test is performed on a tissue sample that is usually obtained via a biopsy procedure. This sample is then processed in a lab where it's stained with antibodies specific to the GPC3 protein. The stained sample is examined under a microscope to detect the presence and quantity of GPC3.

    The primary risks associated with this test are those related to the biopsy procedure used to obtain the tissue sample. These may include pain, bleeding, infection, or reactions to anesthesia.

    It's not typically known for medications to affect the results of this test. However, it's important to inform your healthcare provider of all medications, supplements, and herbal products you're currently using.

    No, the GPC3 test alone isn't definitive for a cancer diagnosis. While the presence of GPC3 can indicate certain types of cancer, including HCC, it's one piece of the diagnostic puzzle. Additional tests and examinations are usually required for a definitive diagnosis.

    If GPC3 is detected, it may indicate the presence of certain types of cancer, especially hepatocellular carcinoma. However, it doesn't necessarily mean cancer is present as some noncancerous conditions may also cause elevated GPC3. Your healthcare provider will interpret your results in the context of your overall health and additional test results.

    The GPC3 test plays a significant role in diagnosing and managing certain cancers. However, it should be noted that a positive result should be interpreted carefully and in conjunction with other diagnostic tools. It's essential to discuss any concerns or questions you might have about this test with your healthcare provider. While the GPC3 test can provide valuable information about your health, it's crucial to remember that maintaining a balanced lifestyle, undergoing routine health check-ups, and consulting your doctor promptly if you notice any health changes can go a long way in disease prevention and early detection.

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