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IHC - GLUT-1 Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Immunohistochemistry for GLUT-1 is a highly specific procedure conducted on a biopsy or surgical sample of the suspected tumor. The purpose of the IHC for GLUT-1 is to visualize the presence and localization of the GLUT-1 protein within the cells, thereby helping in diagnosing various malignancies. This test is usually ordered when a patient has signs and symptoms suggesting a malignancy, and other diagnostic tests are inconclusive. It helps provide valuable information about the nature of the tumor – its aggressiveness, origin, and potential response to therapy.

The test uses an antibody that binds specifically to GLUT-1, which is then visualized using a microscope after applying a chromogenic substrate. If the GLUT-1 protein is present, it will be stained, and its distribution within the sample can be assessed.

The IHC for GLUT-1 is an essential tool in the histopathological evaluation of tumors. However, the results should always be interpreted in the context of clinical findings, other diagnostic results, and the known limitations of the method. While positive staining indicates the presence of the GLUT-1 protein and suggests a potential malignancy, it does not establish a definitive diagnosis of cancer. Therefore, it is crucial to combine this test with other diagnostic methods for an accurate diagnosis.

  • Test Name: IHC - GLUT-1
  • Sample Type: Tissue
  • Preparations Required: No specific instructions needed.
  • Report Time: 3 days

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

Glucose Transporter 1 (GLUT-1) is a protein that helps transport glucose into cells. It is present in many tissues but plays a significant role in carrying glucose across the blood-brain barrier.

The IHC for GLUT-1 test is performed to help diagnose various malignancies. It is also used to detect GLUT-1 deficiency syndrome, which affects the nervous system.

A positive result indicates the presence of GLUT-1 in the sample. This is often associated with various malignancies, as tumor cells usually have increased glucose metabolism. However, a positive result doesn't conclusively diagnose cancer; it needs to be combined with other diagnostic methods.

No specific preparation is needed for this test.

The sample is typically collected through a biopsy or surgical extraction of the suspected tumor.

The test itself isn't painful. However, the biopsy procedure can cause discomfort. Local or general anesthesia is usually used to reduce any pain.

The risks associated with the biopsy procedure include bleeding, infection, and an adverse reaction to anesthesia. However, these risks are relatively low as the procedure is performed under sterile conditions.

A negative result means that GLUT-1 was not detected in the sample. However, it doesn't rule out the presence of a malignancy, as not all tumors express GLUT-1.

The IHC for GLUT-1 test is typically ordered by oncologists, pathologists, or other doctors involved in diagnosing and managing cancer.

Yes, the test can be used to monitor the response to treatment in some cases, especially if the initial test was positive.

Other tests that might be performed along with the IHC for GLUT-1 test include other IHC tests, imaging studies, and molecular tests, depending on the clinical scenario.

Certain factors, such as improper sample handling or technical issues with the IHC procedure, can affect the accuracy of the test results.

No, this test requires a tissue sample that needs to be collected by a healthcare professional and analyzed in a lab.

If you have an abnormal result, you should consult with an oncologist, a doctor who specializes in diagnosing and treating cancer.

In addition to its role in cancer diagnosis, GLUT-1 is also important in diagnosing GLUT-1 deficiency syndrome, a rare genetic metabolic disorder that affects glucose transportation to the brain. Increased GLUT-1 can also be seen in some inflammatory conditions.

The expression of GLUT-1 is typically not influenced by diet or lifestyle. However, your doctor may give specific instructions to follow before the biopsy procedure.

Cancer cells often have an altered metabolism, requiring more glucose than normal cells. This phenomenon is known as the Warburg effect. Therefore, these cells tend to express higher levels of glucose transporters, including GLUT-1, to meet their energy requirements. The presence of GLUT-1 can thus suggest a potentially malignant growth.

The result is usually reported as positive or negative based on the presence or absence of staining for GLUT-1. However, the interpretation should take into account the patient's clinical history, type of tissue sampled, and other laboratory and imaging findings.

Yes, there are different types of GLUT (glucose transporters), each having a unique distribution and function. For instance, GLUT-2 is found in the liver, GLUT-3 in neurons, and GLUT-4 in muscle and fat cells. The different types of GLUTs allow cells to control glucose uptake according to their specific needs.

Like any diagnostic test, the IHC for GLUT-1 is not 100% accurate. There can be false-positive results (where the test indicates GLUT-1 presence when it's not actually there) and false-negative results (where the test fails to detect GLUT-1 when it is there). Various factors can contribute to inaccurate results, including technical issues, sample quality, or the presence of other diseases.

Immunohistochemistry for GLUT-1 is a critical part of modern oncology diagnostics. It allows for a better understanding of tumor biology and aids in the determination of the most appropriate therapeutic strategy. While the test has its limitations, when used alongside other diagnostic methods, it provides invaluable insight into the nature of the tumor and the likely course of the disease. Always remember, the better informed you are about your health, the better decisions you can make alongside your healthcare team.

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