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IHC - CD57

Immunohistochemistry (IHC) is a technique that uses antibodies to detect specific proteins, such as antigens, in tissue samples. One such antigen is CD57, also known as Leu-7 or HNK-1 (Human Natural Killer-1). IHC testing for CD57 is a tool that pathologists use to identify and visualize specific cells that express this antigen in tissue samples.

CD57 is typically expressed on the surface of a subset of natural killer (NK) cells and T lymphocytes, which play an important role in our immune system. It is also found on the surface of some neurons and other cell types. Certain conditions, including some autoimmune diseases and chronic infections like Lyme disease, have been associated with low numbers of CD57-positive cells. On the other hand, certain types of cancers like neuroendocrine tumors and small cell lung carcinomas often show an increased number of these cells.

  • Test NameIHC - CD57
  • Sample TypeTissue
  • Preparations RequiredNo specific preparation is required for this test.
  • Report Time3 days

What is the IHC - CD57 test used for?

The IHC - CD57 test is used primarily in research and sometimes in clinical settings to identify cells expressing the CD57 antigen. This could provide insight into certain health conditions and guide treatment decisions.

Do I need to fast for this test?

No, fasting is not necessary for the IHC - CD57 test. You only need to provide a tissue sample.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

A tissue sample, often a biopsy, is needed for this test. The exact type of sample and the method of its collection will depend on the location of the tissue being tested.

In the IHC - CD57 test, the tissue sample is fixed and sectioned into thin slices. These slices are then incubated with an antibody that binds to CD57. If CD57 is present, it will bind to the antibody, which can then be visualized under a microscope.

The pain associated with this test is usually related to the collection of the tissue sample. Depending on the location of the sample, a local anesthetic may be used to minimize discomfort.

Your doctor may have ordered this test if they suspect a condition that could be associated with changes in the number or distribution of CD57-positive cells, such as certain types of cancer or Lyme disease.

An abnormal result could indicate an increased or decreased number of CD57-positive cells, which could be associated with various health conditions. However, an abnormal result is not diagnostic on its own and should be interpreted in the context of other clinical findings and tests.

No specific preparation is necessary for the IHC - CD57 test. You should follow your healthcare provider's instructions regarding the collection of the tissue sample.

The primary risk associated with the IHC - CD57 test is related to the collection of the tissue sample, which could lead to bleeding, infection, or other complications, depending on the location of the tissue.

Once the test is completed, the results will be sent to your healthcare provider, who will then discuss them with you.

Other tests may be performed in conjunction with the IHC - CD57 test, including other immunohistochemical tests, blood tests, or imaging studies, depending on your specific situation.

While the IHC - CD57 test can indicate the presence of certain cells associated with cancer, it is not a standalone test for cancer diagnosis. It should be used in conjunction with other diagnostic tools.

Changes in the number of CD57-positive cells can suggest certain conditions but are not definitive on their own. Results should always be interpreted in the context of your overall health and other test results.

Technical issues such as the quality of the tissue sample and the staining process can affect the results. Other factors, such as recent infections or medications, may also influence the number of CD57-positive cells.

If your test result is abnormal, you may need to consult a hematologist, immunologist, oncologist, or another specialist, depending on your overall health and specific condition.

Understanding the cellular components of tissue samples is a critical part of diagnosing and monitoring various health conditions. The IHC - CD57 test is one tool that can provide valuable insight into the presence and number of CD57-positive cells. As with any test, results should be interpreted in the context of your overall health and other clinical findings.

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