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IHC - CD117 (C-KIT)

The IHC - CD117 (C-KIT) test is an immunohistochemistry procedure that detects the presence of the CD117 protein, also known as the c-KIT receptor, in tissue samples. CD117 is a type of protein known as a tyrosine kinase receptor, which plays a key role in cell communication and signal transduction. This protein is crucial for the growth and development of certain types of cells, including melanocytes, germ cells, mast cells, and interstitial cells of Cajal.

Alterations in the CD117 gene or overexpression of the CD117 protein have been associated with a number of cancers, including gastrointestinal stromal tumors (GISTs), mast cell diseases, and certain types of leukemia. As such, testing for CD117 can help with diagnosis and may guide treatment decisions, as targeted therapies exist for some conditions with CD117 involvement.

  • Test NameIHC - CD117 (C-KIT)
  • Sample TypeTissue
  • Preparations RequiredNo specific preparation is required for this test.
  • Report Time3 days

What is the IHC - CD117 (C-KIT) test used for?

This test is used primarily to help diagnose certain types of cancers, such as GISTs and some leukemias. It can help to confirm a diagnosis or rule out other conditions.

How is the test performed?

The test is performed on a tissue sample, usually obtained through a biopsy. The sample is examined under a microscope to check for the presence and extent of the CD117 protein.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

A positive result indicates the presence of the CD117 protein in the cells tested. This may suggest a CD117-related disease or condition, such as GIST or certain types of leukemia. However, results should always be interpreted in the context of clinical and other diagnostic findings.

A negative result means the CD117 protein was not detected in the sample. This could mean that a CD117-related disease is not present, or it might suggest another diagnosis.

Yes. Certain therapies, known as targeted therapies, specifically target cells that express the CD117 protein. If your test results show that you have a high amount of this protein, your healthcare provider may consider these types of treatments.

No specific preparation is needed for this test. However, it's always a good idea to discuss any medications or supplements you're taking with your healthcare provider beforehand.

The risks associated with this test are mainly related to the biopsy procedure used to obtain the tissue sample. This can include pain, infection, bleeding, or other complications. However, these risks are generally low.

The turnaround time for this test is typically 3-7 days, but it can vary depending on the lab.

Your healthcare provider will discuss the results with you and explain what they mean. They may also order additional tests or discuss potential treatment options based on the results.

While CD117 is most often associated with certain types of cancer, alterations in the CD117 gene can also be involved in other conditions, such as systemic mastocytosis and piebaldism. However, the use of this test for these conditions is less common.

Yes, you can eat and drink normally before the test. There are no dietary restrictions for this test.

Yes, you can take your medications as usual. However, it's always a good idea to tell your healthcare provider about any medications you're taking.

Whether you need to have this test more than once depends on various factors, including your diagnosis, your treatment plan, and how you respond to treatment.

Coverage for this test will depend on your health insurance plan. It's recommended that you check with your insurance provider to understand what your plan covers.

If you have further questions, don't hesitate to ask your healthcare provider. They are there to help you understand more about your health and the tests you're undergoing.

The IHC - CD117 (C-KIT) test is generally considered reliable for detecting the presence of the CD117 protein. However, no test is 100% accurate, and results should always be interpreted in the context of other clinical and diagnostic findings.

The IHC - CD117 (C-KIT) test is primarily used to diagnose certain types of cancer. However, it can also be used in the diagnosis of other conditions where CD117 overexpression is observed, such as mastocytosis.

While this test cannot directly predict disease progression, the presence or absence of CD117 can provide valuable information about the type and nature of the disease, which can help guide prognosis and treatment decisions.

The test specifically looks for the CD117 protein, so the presence of other conditions should not interfere with the results. However, certain medications or treatments may potentially impact the levels of CD117.

This test is usually performed on a tissue biopsy sample as the CD117 protein is typically located in cells within tissue. Other sample types are not typically used.

Your doctor may order other tests to get a more comprehensive understanding of your condition, to confirm a diagnosis, or to rule out other possible conditions.

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