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IHC - BerEP4

Immunohistochemistry (IHC) is a powerful tool used in pathology to examine the distribution and presence of specific proteins in tissues, using antibodies that bind to these proteins. One such antibody is BerEP4, which is extensively used in diagnostic pathology.

BerEP4 is a monoclonal antibody that recognizes two glycoproteins associated with the human epithelial antigen (Ep-CAM), found on the surface of most epithelial cells. This means that BerEP4 can be used to identify epithelial tissue, including abnormal or cancerous cells that originated from epithelial tissue.

Using IHC to identify proteins like BerEP4 in a tissue sample is often a critical step in diagnosing various forms of cancer. The presence or absence of this protein can provide clues about the nature of a tumor and can guide treatment decisions.

  • Test NameIHC - BerEP4
  • Sample TypeTissue
  • Preparations RequiredNone
  • Report Time3 days

Why is the IHC - BerEP4 test done?

The IHC - BerEP4 test is usually performed to confirm whether a suspected tumor originated from epithelial cells. BerEP4 binds to most epithelial cells, making it a useful tool in diagnosing cancers that originate from these cells, like many types of carcinomas.

Is there any specific preparation required for this test?

No specific preparation is needed for the IHC - BerEP4 test. It is performed on a tissue sample, typically obtained through a biopsy or surgery.

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Frequently Asked Questions

No, fasting is not required for this test as it is performed on a tissue sample.

The sample for this test is typically a tissue sample obtained through a biopsy or during surgical removal of a tumor. The collected tissue is then processed and stained with the BerEP4 antibody for analysis under a microscope.

The IHC - BerEP4 test measures the presence and distribution of the Ep-CAM antigen in a tissue sample using the BerEP4 antibody. A positive result typically indicates that the cells in question are of epithelial origin.

This test is generally performed when there is a need to identify the tissue origin of a tumor. It is not a regular screening or monitoring test.

Normal values can vary depending on the tissue being tested. Epithelial cells should show positive staining with BerEP4, while non-epithelial cells should not.

As this test is performed on a tissue sample, the primary precautions involve ensuring proper collection and handling of the tissue to prevent degradation or contamination.

The levels of BerEP4 are not typically affected by lifestyle or environmental factors, as they reflect the tissue type rather than physiological changes or responses.

The primary non-modifiable factor that can affect BerEP4 levels is the tissue type. Epithelial cells should express the Ep-CAM antigen and thus stain positively with BerEP4.

Abnormal levels of BerEP4 can indicate a tumor of epithelial origin. However, it's essential to interpret these results in the context of other clinical and diagnostic findings.

The levels of BerEP4 in a tissue sample are primarily determined by the type of tissue. The presence of BerEP4 indicates epithelial cells, which is not influenced by modifiable factors like diet or lifestyle.

An abnormal BerEP4 value should be discussed with a pathologist or an oncologist, who can interpret the results in the context of other diagnostic and clinical information.

In diagnosing cancer, the IHC - BerEP4 test helps identify whether a tumor is of epithelial origin, which can aid in diagnosing carcinomas.

The IHC - BerEP4 test primarily identifies the tissue type and is not typically used to stage cancer. Other tests and assessments are usually needed to determine the stage of cancer.

Immunohistochemistry, including the use of markers like BerEP4, has revolutionized the field of pathology, providing an ability to visualize and identify specific proteins within tissue samples. This has significantly improved the ability to diagnose and classify cancers, ultimately leading to more targeted and effective treatments. Despite its utility, the IHC - BerEP4 test is just one piece of the puzzle and must be interpreted alongside other tests and clinical findings to ensure an accurate diagnosis and appropriate treatment plan.

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