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IHC - Bcl-2 Oncoprotein

Bcl-2 is an oncoprotein, a type of protein that is involved in the regulation of cell death or apoptosis. It gets its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. An increase in Bcl-2 expression has been associated with a variety of different cancers, including breast, lung, and prostate cancer, as well as lymphomas and leukemias.

The IHC - Bcl-2 oncoprotein test uses immunohistochemistry (IHC), a laboratory method that utilizes antibodies to detect specific proteins in cells within a tissue section. This test specifically identifies the presence of Bcl-2 oncoprotein in a sample of your tissue.

  • Test NameIHC - Bcl-2 Oncoprotein
  • Sample TypeTissue Sample
  • Preparations RequiredThere are no specific instructions for patients for this test as the sample will be obtained by your healthcare provider during a biopsy or surgical procedure
  • Report Time3 days

What is the importance of the IHC - Bcl-2 oncoprotein test?

This test is important in diagnosing and classifying cancers, particularly lymphomas. It can also provide prognostic information, and guide treatment decisions.

Is fasting required for the IHC - Bcl-2 oncoprotein test?

No, fasting is not required for this test. It is performed on a tissue sample obtained during a biopsy or surgical procedure.

Home Sample Collection Process
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Sample Collection by Phlebotomist
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Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

This test is usually recommended when there is a suspicion of cancer, particularly lymphomas, based on other diagnostic tests and clinical symptoms.

This test identifies the presence of Bcl-2 oncoprotein in a tissue sample. High levels of Bcl-2 oncoprotein can indicate the presence of cancer.

The frequency of this test depends on your specific condition and should be determined by your healthcare provider.

Normal cells may express low levels of Bcl-2. However, high levels are often found in cancer cells. The exact levels can depend on the specific laboratory performing the test and the method they use.

There are no specific precautions to be taken before the test. However, as it involves a biopsy or surgical procedure, any general precautions related to these procedures should be followed.

Certain treatments, such as chemotherapy or radiation therapy, can affect the levels of Bcl-2 in your cells. Other factors may include your overall health, age, and genetic factors.

If your test results are abnormal, you should consult with an oncologist or hematologist, as they specialize in the diagnosis and treatment of cancers.

Further diagnostic tests may include imaging studies, genetic tests, or additional immunohistochemistry tests to identify other potential cancer markers.

While lifestyle factors may influence the risk of developing cancer, they do not directly affect the levels of Bcl-2 oncoprotein in your cells.

The test itself is not painful, but obtaining the tissue sample can be, depending on the site of the biopsy and the type of anesthesia used.

No, the IHC - Bcl-2 oncoprotein test is a complex procedure that requires specialized equipment and trained professionals. It cannot be done at home.

If your Bcl-2 oncoprotein levels are high, your doctor will likely recommend further tests or treatments based on your specific condition.

With successful treatment, it is possible for Bcl-2 oncoprotein levels to decrease. However, regular monitoring is important to ensure the disease is under control.

In conclusion, the IHC - Bcl-2 oncoprotein test is a valuable tool in the diagnosis and management of certain cancers. Like any diagnostic test, results should be interpreted in the context of the patient's overall clinical condition and in consultation with a healthcare provider.

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