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IHC - Alpha-1-Antitrypsin Diagnostic Test

Alpha-1-Antitrypsin (A1AT) is a protein that's produced by the liver and released into the bloodstream. It helps protect the lungs from damage caused by inflammation, which can be triggered by infections or inhaled irritants like tobacco smoke. In some cases, the A1AT protein doesn't function properly due to genetic mutations. This can lead to Alpha-1-Antitrypsin Deficiency (AATD), a condition that increases the risk of lung and liver diseases. The IHC - Alpha-1-Antitrypsin diagnostic test is designed to detect abnormal levels of A1AT in tissue samples, providing valuable information for the diagnosis and management of AATD and associated conditions.

An Immunohistochemistry (IHC) technique is used in this test to visually represent the presence and location of A1AT in tissue samples. This highly specialized test can be instrumental in identifying abnormal A1AT proteins in tissues, aiding in the diagnosis of AATD and providing crucial data for evaluating the severity and potential progression of the disease

  • Test NameIHC - Alpha-1-Antitrypsin Diagnostic Test
  • Sample TypeTissue
  • Preparations RequiredNo specific instructions are required for this test unless instructed otherwise by your healthcare provider.
  • Report Time5 days

Why would a doctor order an IHC - Alpha-1-Antitrypsin test?

Your doctor might order this test if you have symptoms of AATD, such as shortness of breath, reduced ability to exercise, wheezing, recurrent respiratory infections, or unexpected liver disease. The test can help confirm the diagnosis and guide treatment decisions.

Are there any special preparations required for the test?

No specific preparation is required for the IHC - Alpha-1-Antitrypsin test. However, it's important to inform your doctor about any medications or supplements you're taking, as some substances might interfere with the results.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

Fasting is not required before the IHC - Alpha-1-Antitrypsin test. You can follow your usual diet unless instructed otherwise by your healthcare provider.

A tissue sample is used for the IHC - Alpha-1-Antitrypsin test. This is typically obtained through a biopsy or during surgery.

The test provides information about the presence and levels of Alpha-1-Antitrypsin in the tissue sample. This can help in diagnosing AATD and in assessing the severity of the condition. The results can also provide insights into the patient's risk of developing lung or liver diseases associated with AATD.

The frequency of the test depends on the individual's condition and the doctor's recommendation. In general, the test may be performed as part of the diagnostic process when AATD is suspected or to monitor the progress of the disease over time.

Normal values can vary, but generally, a normal result means that the amount of Alpha-1-Antitrypsin in the tissue is within the expected range. However, interpretation of results should be performed by a healthcare provider who can consider the patient's overall clinical situation.

No specific precautions are needed after the test. However, if the test was performed as part of a biopsy or surgical procedure, follow the post-procedure care instructions given by your healthcare provider.

Various factors can affect Alpha-1-Antitrypsin levels, including genetic factors (such as mutations in the A1AT gene), lifestyle factors (such as smoking), and certain medical conditions (such as liver disease).

If you have abnormal Alpha-1-Antitrypsin levels, you should consult a pulmonologist or a hepatologist, depending on your symptoms. These specialists can provide appropriate guidance for the management of AATD and associated conditions.

In this test, an IHC technique is used to detect the presence and levels of Alpha-1-Antitrypsin in tissue samples. The sample is treated with antibodies that bind to Alpha-1-Antitrypsin, and then a color reaction is triggered, allowing the Alpha-1-Antitrypsin to be visualized under a microscope.

The IHC - Alpha-1-Antitrypsin test itself is not painful. However, the process of obtaining a tissue sample for the test, such as a biopsy or surgical procedure, may involve some discomfort or pain.

While there's currently no cure for AATD, the condition can be managed with appropriate treatment strategies. These can include lifestyle changes, medication, pulmonary rehabilitation, or in some cases, liver transplant.

Coverage for the IHC - Alpha-1-Antitrypsin test will depend on your health insurance plan. It's best to check with your insurance provider to understand your coverage details.

No, the IHC - Alpha-1-Antitrypsin test requires a tissue sample, which must be collected by a healthcare professional. The test also requires specialized laboratory equipment and should be performed in a laboratory setting.

In conclusion, the IHC - Alpha-1-Antitrypsin test plays a crucial role in the diagnosis and management of Alpha-1-Antitrypsin Deficiency and associated conditions. By providing information about the presence and levels of A1AT in tissue samples, it helps guide treatment decisions and monitor disease progression. Always consult with your healthcare provider for personalized medical advice based on your specific condition and test results.

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