IHC - ALK-D5F3 Test for Lung Tumors, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific instructions are necessary for this test unless specified by your healthcare provider.

₹ 6900


The IHC - ALK-D5F3 test is a specialized examination that helps detect ALK (Anaplastic Lymphoma Kinase) gene rearrangements in lung tumor tissue. This test is critical in diagnosing certain types of lung cancers and guides the treatment plan, specifically in determining the suitability for targeted therapy. It is particularly useful in identifying Non-Small Cell Lung Cancer (NSCLC) patients who may benefit from ALK inhibitors, which are targeted therapies designed to block the growth of cancer cells.

This diagnostic procedure utilizes Immunohistochemistry (IHC) and a highly specific antibody, ALK-D5F3, to visualize and detect the presence of abnormal ALK proteins in the tissue sample. The FDA-approved clone ensures the test's reliability, yielding valuable insights into the patient's condition and providing data to assist in tailoring effective therapeutic strategies

Test Name IHC - ALK-D5F3 for Lung Tumors (FDA approved clone)
Sample Type Tissue
Preparations Required No specific instructions are necessary for this test unless specified by your healthcare provider.
Report Time 5 Days
Price in Hyderabad ₹ 6900

What is the significance of the IHC - ALK-D5F3 test?

This test is essential in diagnosing certain lung cancers, particularly Non-Small Cell Lung Cancer. It aids in determining if a patient can benefit from ALK inhibitors, a targeted treatment method that inhibits cancer cell growth.

Are there any special preparations required before the test?

No special preparations are needed for this test. However, it's important to inform your doctor about any medications, supplements, or underlying health conditions as they may affect the test results.

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Is fasting required before the test?

Fasting is not required before the IHC - ALK-D5F3 test.

What type of sample is required for this test?

A tissue sample from the lung tumor is needed for this test, typically obtained through a biopsy procedure.

What information does this test provide?

The IHC - ALK-D5F3 test identifies the presence and extent of abnormal ALK proteins in lung tissue. This information helps diagnose certain lung cancers and guides the selection of appropriate targeted therapies.

How often should this test be performed?

The frequency of this test depends on the patient's condition and the treating physician's recommendation. It is usually performed when diagnosing lung cancer and determining a suitable treatment plan.

What are the normal values for this test?

Normal results would show no abnormal ALK proteins in the tissue sample. However, results should always be interpreted by a healthcare provider considering the patient's overall clinical situation.

What precautions should be taken after the test?

No specific precautions are required after the test. However, after a biopsy or surgical procedure used to obtain a tissue sample, you should follow the post-procedure care instructions provided by your healthcare team.

What factors can affect the levels of ALK proteins?

The main factor affecting the levels of ALK proteins is genetic alterations in the ALK gene, leading to an overproduction of these proteins. Certain environmental factors, like smoking, may also affect ALK levels, but their impact is less understood.

Which doctor should I consult if I have abnormal ALK protein levels?

If you have abnormal ALK protein levels, you should consult an oncologist. They can guide you on the appropriate treatment options, which may include targeted therapy with ALK inhibitors.

How is the IHC - ALK-D5F3 test performed?

The test uses IHC to detect abnormal ALK proteins in a tissue sample. The tissue is treated with ALK-D5F3 antibodies that bind to the ALK proteins. The subsequent color reaction allows the proteins to be visualized under a microscope.

Is the test painful?

The test itself isn't painful. However, the biopsy procedure to obtain a tissue sample can cause some discomfort.

Can lung cancer be cured with ALK inhibitors?

While ALK inhibitors can't cure lung cancer, they can help manage the disease by blocking the growth of cancer cells. They're especially effective in lung cancer patients with ALK gene rearrangements.

Is the IHC - ALK-D5F3 test covered by insurance?

Insurance coverage varies greatly, so it's best to check with your provider about coverage details.

Can I do this test at home?

No, this test requires a tissue sample and specialized laboratory equipment. It must be conducted in a laboratory setting.

Can the test be performed on a non-cancerous (benign) tissue sample?

Yes, the IHC - ALK-D5F3 test can technically be performed on any tissue sample. However, it is typically performed on lung tumor tissue since its primary purpose is to identify ALK gene rearrangements associated with certain types of lung cancer.

How long does it take to get results from the test?

The turn-around time can vary but is typically between 2-4 days. It might take longer in certain circumstances, depending on the lab and its workload.

Can this test help determine the stage of lung cancer?

While the IHC - ALK-D5F3 test itself does not stage lung cancer, it can provide valuable information about the molecular characteristics of the tumor, which along with other tests, can contribute to the overall understanding of the cancer's progress and aggressiveness.

Does this test replace other diagnostic methods for lung cancer?

No, the IHC - ALK-D5F3 test does not replace other diagnostic methods. It is typically used in conjunction with other tests, such as imaging studies and other laboratory tests, to form a comprehensive understanding of the patient's condition.

Are there any side effects associated with the test?

The test itself does not have side effects, but obtaining the tissue sample via a biopsy procedure may have potential risks, including infection and bleeding. It is important to discuss these risks with your healthcare provider.

Can medications affect the results of the test?

While medications do not directly affect the results of the IHC - ALK-D5F3 test, they may have an impact on the patient's overall health and other laboratory test results. It is crucial to inform your doctor about any medications you are taking before the test.

Are there any diseases or conditions that may cause similar test results?

This test specifically identifies ALK gene rearrangements, primarily seen in certain types of lung cancer. Other types of cancers may also present ALK rearrangements, but they are less common.

What is the next step if the test results are positive?

If the test results are positive, it suggests the presence of an ALK gene rearrangement, which means the patient might benefit from targeted therapy with ALK inhibitors. The oncologist will discuss the best treatment options based on these and other test results.

How reliable is this test?

The IHC - ALK-D5F3 test is highly reliable, particularly because it uses an FDA-approved clone. However, like any test, it should be interpreted in the context of the patient's overall clinical picture.

If the test is negative, can lung cancer be ruled out?

No, a negative result does not rule out lung cancer. It merely suggests the absence of an ALK gene rearrangement, which is one specific characteristic found in certain lung cancers. Other tests are necessary for a comprehensive diagnosis.

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