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IHC - ALK-D5F3 for Lung Tumors (FDA approved clone)

The IHC - ALK-D5F3 test is a specialized examination that helps detect ALK (Anaplastic Lymphoma Kinase) gene rearrangements in lung tumor tissue. This test is critical in diagnosing certain types of lung cancers and guides the treatment plan, specifically in determining the suitability for targeted therapy. It is particularly useful in identifying Non-Small Cell Lung Cancer (NSCLC) patients who may benefit from ALK inhibitors, which are targeted therapies designed to block the growth of cancer cells.

This diagnostic procedure utilizes Immunohistochemistry (IHC) and a highly specific antibody, ALK-D5F3, to visualize and detect the presence of abnormal ALK proteins in the tissue sample. The FDA-approved clone ensures the test's reliability, yielding valuable insights into the patient's condition and providing data to assist in tailoring effective therapeutic strategies

  • Test NameIHC - ALK-D5F3 for Lung Tumors (FDA approved clone)
  • Sample TypeTissue
  • Preparations RequiredNo specific instructions are required for this test, as it is performed on a tissue sample usually obtained via biopsy.
  • Report Time3 days

What is the significance of the IHC - ALK-D5F3 test?

This test is essential in diagnosing certain lung cancers, particularly Non-Small Cell Lung Cancer. It aids in determining if a patient can benefit from ALK inhibitors, a targeted treatment method that inhibits cancer cell growth.

Are there any special preparations required before the test?

No special preparations are needed for this test. However, it's important to inform your doctor about any medications, supplements, or underlying health conditions as they may affect the test results.

Home Sample Collection Process

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Reporting of the sample at lab
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Frequently Asked Questions

Fasting is not required before the IHC - ALK-D5F3 test.

A tissue sample from the lung tumor is needed for this test, typically obtained through a biopsy procedure.

The IHC - ALK-D5F3 test identifies the presence and extent of abnormal ALK proteins in lung tissue. This information helps diagnose certain lung cancers and guides the selection of appropriate targeted therapies.

The frequency of this test depends on the patient's condition and the treating physician's recommendation. It is usually performed when diagnosing lung cancer and determining a suitable treatment plan.

Normal results would show no abnormal ALK proteins in the tissue sample. However, results should always be interpreted by a healthcare provider considering the patient's overall clinical situation.

No specific precautions are required after the test. However, after a biopsy or surgical procedure used to obtain a tissue sample, you should follow the post-procedure care instructions provided by your healthcare team.

The main factor affecting the levels of ALK proteins is genetic alterations in the ALK gene, leading to an overproduction of these proteins. Certain environmental factors, like smoking, may also affect ALK levels, but their impact is less understood.

If you have abnormal ALK protein levels, you should consult an oncologist. They can guide you on the appropriate treatment options, which may include targeted therapy with ALK inhibitors.

The test uses IHC to detect abnormal ALK proteins in a tissue sample. The tissue is treated with ALK-D5F3 antibodies that bind to the ALK proteins. The subsequent color reaction allows the proteins to be visualized under a microscope.

The test itself isn't painful. However, the biopsy procedure to obtain a tissue sample can cause some discomfort.

While ALK inhibitors can't cure lung cancer, they can help manage the disease by blocking the growth of cancer cells. They're especially effective in lung cancer patients with ALK gene rearrangements.

Insurance coverage varies greatly, so it's best to check with your provider about coverage details.

No, this test requires a tissue sample and specialized laboratory equipment. It must be conducted in a laboratory setting.

Yes, the IHC - ALK-D5F3 test can technically be performed on any tissue sample. However, it is typically performed on lung tumor tissue since its primary purpose is to identify ALK gene rearrangements associated with certain types of lung cancer.

The turn-around time can vary but is typically between 2-4 days. It might take longer in certain circumstances, depending on the lab and its workload.

While the IHC - ALK-D5F3 test itself does not stage lung cancer, it can provide valuable information about the molecular characteristics of the tumor, which along with other tests, can contribute to the overall understanding of the cancer's progress and aggressiveness.

No, the IHC - ALK-D5F3 test does not replace other diagnostic methods. It is typically used in conjunction with other tests, such as imaging studies and other laboratory tests, to form a comprehensive understanding of the patient's condition.

The test itself does not have side effects, but obtaining the tissue sample via a biopsy procedure may have potential risks, including infection and bleeding. It is important to discuss these risks with your healthcare provider.

While medications do not directly affect the results of the IHC - ALK-D5F3 test, they may have an impact on the patient's overall health and other laboratory test results. It is crucial to inform your doctor about any medications you are taking before the test.

This test specifically identifies ALK gene rearrangements, primarily seen in certain types of lung cancer. Other types of cancers may also present ALK rearrangements, but they are less common.

If the test results are positive, it suggests the presence of an ALK gene rearrangement, which means the patient might benefit from targeted therapy with ALK inhibitors. The oncologist will discuss the best treatment options based on these and other test results.

The IHC - ALK-D5F3 test is highly reliable, particularly because it uses an FDA-approved clone. However, like any test, it should be interpreted in the context of the patient's overall clinical picture.

No, a negative result does not rule out lung cancer. It merely suggests the absence of an ALK gene rearrangement, which is one specific characteristic found in certain lung cancers. Other tests are necessary for a comprehensive diagnosis.

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