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Homocysteine

Homocysteine Blood Test

The Homocysteine Blood Test is a diagnostic tool used to measure the amount of homocysteine, an amino acid, in your blood. Amino acids are the building blocks of proteins. Homocysteine is produced when your body breaks down an essential amino acid called methionine. Normally, vitamin B12, vitamin B6, and folic acid break down homocysteine and change it back into methionine or another substance called cysteine. Any disruptions in this process can lead to elevated homocysteine levels in the blood.

High levels of homocysteine in the blood can damage the lining of the arteries, leading to blood clots, heart disease, and stroke. Elevated homocysteine levels can also be indicative of a vitamin B12 or folic acid deficiency, kidney disease, hypothyroidism, or certain genetic disorders.


  • Test NameHomocysteine Blood Test
  • Sample TypeBlood
  • Preparations RequiredNo specific instructions. No fasting required. Continue with your normal diet and medications unless instructed otherwise by your doctor
  • Report Time4 hours

Why is the Homocysteine test done?

The homocysteine test is primarily used to help determine if a person is deficient in vitamin B12 or folic acid. It can also be used to evaluate the overall risk of heart disease and stroke, especially in cases where a person has a family history of early heart disease but no other known risk factors.

How is the test performed?

The test is performed with a standard blood draw, usually from a vein in the arm.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Download Reports
Frequently Asked Questions

Normal levels of homocysteine in the blood are generally between 4.4 and 10.8 micromoles per liter (┬Ámol/L). High levels could indicate a deficiency in vitamin B12 or folic acid, a problem with the kidneys, or a family tendency to high homocysteine levels.

Yes, regular exercise and a diet rich in fruits and vegetables can help lower homocysteine levels. In some cases, your doctor might recommend supplements of vitamin B6, vitamin B12, and folic acid.

High levels of homocysteine usually don't cause symptoms but can increase your risk of developing hardened arteries (atherosclerosis), leading to heart attacks and strokes. In rare cases, very high levels can cause mental health problems, blood clots, and visual disturbances.

Certain medications, including anti-epileptic drugs, methotrexate, and niacin, can affect homocysteine levels. Other factors include age, kidney function, vitamin B12 and folic acid levels, and certain genetic variations.

Low levels of homocysteine are generally not a concern and are usually due to high levels of folic acid, vitamin B6, and vitamin B12.

Yes, the homocysteine test is safe to take during pregnancy. In fact, some studies suggest that high homocysteine levels could be associated with complications like pre-eclampsia, premature birth, and low birth weight.

The frequency of this test is determined by your healthcare provider, based on your overall health, risk factors, and whether you're monitoring the effectiveness of treatments for conditions like heart disease.

Yes, other tests, such as cholesterol testing, can assess your risk for heart disease. However, the homocysteine test provides different information and may be useful if you have a personal or family history of cardiovascular disease that can't be explained by traditional risk factors.

If your homocysteine levels are high, it is important to consult with your healthcare provider who can evaluate your results in the context of your overall health, medical history, and specific symptoms. They may suggest dietary changes, vitamin supplements, or other treatments depending on the cause.

Yes, factors such as age, genetics, diet, lifestyle, and certain medical conditions like kidney disease and hypothyroidism can increase the risk of high homocysteine levels.

Yes, certain genetic mutations can lead to excessively high homocysteine levels, a condition called homocystinuria.

Yes, lifestyle changes such as adopting a healthy diet rich in folic acid, vitamins B6 and B12, regular exercise, quitting smoking, and reducing alcohol consumption can help lower homocysteine levels.

The homocysteine test is considered a reliable measure of blood homocysteine levels. However, like all tests, it may have some limitations. Other conditions, medications, and certain dietary factors can affect the results. It's best to discuss the results and their implications with your healthcare provider.

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