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Hepatitis B Virus - Drug Resistance

Hepatitis B Virus - Drug Resistance

Hepatitis B Virus (HBV) infection is a liver infection caused by the hepatitis B virus. Chronic HBV infection can lead to liver cirrhosis, liver failure, and liver cancer. Antiviral medications such as Lamivudine, Telbivudine, Adefovir, Tenofovir, and Entecavir are used to manage HBV infection. However, over time, the virus can develop resistance to these medications. The Hepatitis B Virus - Drug Resistance test detects genetic mutations in the virus that are responsible for resistance to these antiviral drugs. This test is crucial for individuals who are undergoing treatment for chronic HBV infection as it helps doctors to tailor the treatment according to the virus's resistance pattern.

  • Test Name Hepatitis B Virus (HBV) - Drug Resistance (Lamivudine, Telbivudine, Adefovir, Tenofovir, and Entecavir)
  • Sample Type Blood
  • Preparations Required No special preparation is required for this test. However, it is advised to inform your doctor of any medications or supplements you are taking.
  • Report Time 5 days

Drug resistance can occur when the virus mutates, and these mutations allow it to replicate even in the presence of antiviral drugs. Detecting these mutations early helps in adjusting the treatment plan accordingly, preventing the virus from causing further liver damage and avoiding ineffective treatments.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

This test analyzes the genetic material of the hepatitis B virus to identify mutations that can cause resistance to antiviral medications, including Lamivudine, Telbivudine, Adefovir, Tenofovir, and Entecavir.

The test is essential for individuals undergoing treatment for chronic HBV infection. Knowing whether the virus has developed resistance to a particular medication is crucial for adjusting the treatment plan and preventing further liver damage.

Patients with chronic HBV infection who are on antiviral therapy and those who show signs of treatment failure or have elevated liver enzymes despite treatment should consider this test.

A blood sample is drawn from a vein in the arm. The sample is then analyzed in a laboratory for the presence of genetic mutations that are indicative of drug resistance.

If the test detects mutations in the virus's genetic material, it indicates that the virus may be resistant to one or more antiviral medications. Your doctor will use this information to adjust your treatment plan.

Drug resistance can sometimes be minimized by strictly adhering to the medication regimen and monitoring viral load and liver enzymes regularly.

If the virus is resistant to a particular medication, your doctor might change your treatment to a different antiviral drug that the virus is sensitive to.

Your doctor might recommend repeating this test if there is evidence of treatment failure or if your viral load increases despite therapy.

Chronic HBV infection often has no symptoms in the early stages. Later, symptoms may include fatigue, jaundice, abdominal pain, and nausea.

Yes, this test is often done alongside other tests, such as HBV viral load, liver function tests, and sometimes liver imaging studies.

No, fasting is not required for this test.

It is crucial to inform your doctor about all the medications and supplements you are taking, as some of them might interfere with the test results.

If the test results indicate drug resistance, you should consult a hepatologist or an infectious disease specialist.

Drug resistance can lead to a relapse or progression of HBV infection and can result in liver damage, liver cirrhosis, and liver cancer.

Yes, drug-resistant strains of HBV can be transmitted to others through blood or other body fluids.

Understanding the susceptibility of the hepatitis B virus to antiviral medications is key in effectively managing chronic HBV infection. Regular monitoring and appropriate adjustments to the treatment regimen are essential to prevent the progression of liver disease. Patient compliance and open communication with the doctor are critical components for the successful management of chronic HBV infection.

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