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Haptoglobin - Genotype

Haptoglobin - Genotype

Haptoglobin is a protein produced by the liver, and its primary role is to bind free hemoglobin released during the breakdown of red blood cells. This binding prevents kidney damage that could be caused by hemoglobin. There are different forms of haptoglobin, and these are determined by the Haptoglobin gene. The Haptoglobin - Genotype test is used to determine the genetic makeup of the haptoglobin protein in an individual.


  • Test Name Haptoglobin - Genotype
  • Sample Type Blood
  • Preparations Required There are no specific instructions such as fasting needed for this test.
  • Report Time 7 Days

Knowing the haptoglobin genotype is important because different genotypes can affect the body differently. For instance, certain haptoglobin genotypes are associated with an increased risk of cardiovascular disease in individuals with diabetes. This test is also significant in understanding the haptoglobin levels and can be used in diagnosing conditions like hemolytic anemia.

Home Sample Collection Process
1
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Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
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Frequently Asked Questions

The Haptoglobin - Genotype test is a blood test that identifies the genetic variation of haptoglobin, a protein that binds to hemoglobin to prevent it from causing damage to the kidneys.

This test is performed to determine an individual’s haptoglobin genotype, which can have implications on health, especially in conditions like diabetes, where certain genotypes are associated with an increased risk of cardiovascular diseases.

A sample of blood is drawn from the arm and sent to a laboratory for analysis. The lab will analyze the sample to determine the genetic makeup of the haptoglobin protein.

There are mainly three genotypes for haptoglobin: Hp 1-1, Hp 2-1, and Hp 2-2. These genotypes are based on the combinations of two major alleles (Hp1 and Hp2).

People with the Hp 2-2 genotype may have an increased risk of cardiovascular disease if they have diabetes. The Hp 1-1 genotype is associated with a higher haptoglobin concentration and is considered protective against kidney damage.

Individuals with diabetes, especially those at risk for cardiovascular disease, and individuals with suspected hemolytic anemia might benefit from understanding their haptoglobin genotype.

Low levels of haptoglobin could indicate hemolytic anemia, liver disease, or an inflammatory condition. It could also be due to the natural variation based on your haptoglobin genotype.

High levels of haptoglobin can be seen in inflammatory conditions and are sometimes associated with certain infections, cancers, or chronic diseases.

Yes, certain medications and lifestyle choices, such as excessive alcohol consumption, can affect haptoglobin levels.

No special preparation is needed for the Haptoglobin - Genotype test. You can continue with your normal routine and medications unless instructed otherwise by your doctor.

There is very little risk associated with having blood drawn for the test. You might experience slight pain or bruising at the spot where the needle was inserted.

Understanding your haptoglobin genotype can help you and your doctor make more informed decisions about your health, especially if you have conditions like diabetes that can be impacted by your haptoglobin genotype.

No, the haptoglobin genotype test determines the genetic variation of your haptoglobin protein, whereas the haptoglobin level test measures the amount of haptoglobin in your blood.

Genetic factors will determine your haptoglobin genotype. However, for haptoglobin levels, various factors like medications, liver function, and alcohol consumption can affect the levels.

If your test results are abnormal or if you have concerns about your haptoglobin genotype and its implications, it is advisable to consult a general physician or an endocrinologist.

The Haptoglobin - Genotype test is a valuable tool for understanding your genetic makeup regarding the haptoglobin protein. It can offer insights into how your body may handle hemoglobin and your risk factors for certain conditions like cardiovascular disease, especially if you have diabetes. Knowledge of your haptoglobin genotype can guide you and your doctor in making informed healthcare decisions.

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