GCV Resistance by Sequencing Test, Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No specific preparation is needed for this test.

₹ 7000


Ganciclovir (GCV) is an antiviral medication used mainly in the treatment of cytomegalovirus (CMV) infections. CMV is a common virus that can cause disease in individuals with weakened immune systems, such as people with HIV/AIDS or those who have undergone organ transplantation.

Unfortunately, CMV can become resistant to ganciclovir. This can be a significant clinical problem, particularly in immunosuppressed individuals for whom few therapeutic options may be available. Therefore, GCV Resistance by Sequencing, also known as ganciclovir resistance testing, is a critical tool for monitoring patients undergoing treatment for CMV infection.

This test uses sequencing techniques to identify mutations in the UL97 and UL54 genes of the CMV virus, which are associated with resistance to ganciclovir. The presence of specific mutations can guide clinicians in adjusting antiviral therapy to manage CMV disease effectively.

Test Name GCV Resistance by Sequencing
Sample Type Blood or Tissue
Preparations Required No specific preparation is needed for this test.
Report Time 10 days
Price in Hyderabad ₹ 7000

What is the GCV Resistance by Sequencing test?

This test uses DNA sequencing techniques to detect mutations in the CMV virus that are associated with resistance to the antiviral drug ganciclovir.

Why is this test important?

The test is crucial in managing CMV infections, especially in immunocompromised patients. It allows healthcare providers to identify resistance to ganciclovir and adjust treatment strategies accordingly.

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What does the test involve?

The test involves taking a blood or tissue sample from the patient. The sample is sent to a laboratory, where DNA is extracted from the CMV virus, if present, and then sequenced to identify any mutations associated with ganciclovir resistance.

What do the results mean?

If the test detects mutations associated with ganciclovir resistance, it means that the patient's CMV infection may not respond to ganciclovir treatment. The healthcare provider may consider using an alternative antiviral therapy.

What happens after the test?

After the test, your doctor will review the results and discuss the next steps with you. This could involve changing your treatment if the CMV virus in your body is resistant to ganciclovir.

What are the risks associated with this test?

There are minimal risks associated with the blood draw required for this test. You might experience a little pain or bruising at the injection site.

What are the normal values for this test?

In a typical scenario, the CMV virus should not have mutations associated with ganciclovir resistance. If such mutations are detected, it indicates that the virus may be resistant to ganciclovir.

Which doctor should I consult if my test results are abnormal?

If your test results are abnormal, you should consult with the doctor who is managing your CMV infection. This could be an infectious disease specialist or another type of physician depending on your specific situation.

Is fasting required for this test?

No, fasting is not required for the GCV Resistance by Sequencing test.

What symptoms might warrant this test?

This test is typically ordered for patients who have a diagnosed CMV infection and are not responding to ganciclovir treatment as expected. Symptoms of a CMV infection can include fever, fatigue, sore throat, and swollen glands.

How often should this test be done?

The frequency of this test will depend on the clinical situation and the patient's response to therapy. Your doctor will determine when and how often this test should be performed.

Can any factors affect the test results?

The test results could be affected if the sample is not properly collected or stored, or if there is an issue with the lab procedures. However, these are rare occurrences, and the test is generally very reliable.

What are the modifiable factors affecting the levels?

There are no modifiable factors for this test as the resistance to ganciclovir is purely due to mutations in the CMV virus and not influenced by any patient lifestyle factors.

What are non-modifiable factors affecting the levels?

Non-modifiable factors include the specific genetic make-up of the CMV virus infecting the patient. Some viruses may naturally carry resistance mutations.

Can I do this test at home?

No, this test cannot be done at home. It requires a blood or tissue sample to be drawn by a healthcare professional and must be analyzed in a specialized laboratory.

The GCV Resistance by Sequencing test is a valuable tool in managing CMV infections. It aids in early detection of ganciclovir resistance, allowing for timely therapeutic interventions and potentially preventing complications associated with untreated or poorly managed CMV disease. Remember, the best treatment strategies are often based on a combination of clinical assessment and laboratory findings. Always consult your doctor for any questions or concerns regarding CMV infections and treatment options.

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