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Gamma Glutamyl Transferase

Gamma Glutamyl Transferase

Gamma Glutamyl Transferase (GGT) is an enzyme that is found in many organs throughout the body, with the highest concentrations found in the liver. GGT is involved in the transfer of amino acids across the cellular membrane and plays a key role in the metabolism of glutathione, a powerful antioxidant that protects cells from damage.


  • Test Name Gamma Glutamyl Transferase (GGT) Test
  • Sample Type Blood
  • Preparations Required Fasting for 8-10 hours is usually required before the test. Alcohol consumption should be avoided for 24 hours before the test.
  • Report Time 4 hours

A GGT test measures the level of Gamma Glutamyl Transferase in the blood. Elevated levels of GGT often suggest a problem with the liver or bile ducts. This test is often used to diagnose liver diseases, such as cirrhosis, hepatitis, and liver cancer. It can also be used to monitor the treatment of people with alcoholic liver disease or to detect alcohol abuse.

Home Sample Collection Process
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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
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Reporting of the sample at lab
Reporting of the sample at lab
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Frequently Asked Questions

The GGT test is crucial as it aids in diagnosing liver disease. High levels of GGT in the blood can indicate liver damage, inflammation, or blocked bile ducts.

Yes, typically an 8-10 hour fast is required before the GGT test.

Apart from fasting, alcohol consumption should be avoided for 24 hours prior to the test as it can significantly increase GGT levels.

Your doctor might order this test if you exhibit symptoms of a liver disorder, such as jaundice, abdominal pain, nausea, vomiting, or unexplained fatigue.

The test provides information about the level of GGT in your blood. High levels may indicate liver disease or bile duct blockage. It's also used to differentiate between liver-related and non-liver-related causes of elevated alkaline phosphatase (ALP), another enzyme.

The frequency of the test depends on your doctor's recommendation and could be more frequent if you're diagnosed with a liver disorder or if you're monitoring your response to treatment for a liver disease.

Normal values may vary among different laboratories, but typically, they range from 9-48 U/L for men and 6-29 U/L for women.

Precautions involve abstaining from alcohol and certain medications that may affect GGT levels. Your doctor should be informed about any medicines, herbs, or supplements you're taking.

Apart from alcohol and certain medications, factors like age, gender, and body mass index (BMI) can influence GGT levels. Chronic conditions such as diabetes and heart failure can also affect GGT levels.

Modifiable factors include alcohol consumption, diet, and medication intake. Non-modifiable factors encompass genetic predisposition and existing conditions like liver disease or heart failure.

An abnormal GGT test result should prompt a consultation with a gastroenterologist or a hepatologist, specialists in digestive diseases and liver diseases, respectively.

High GGT levels could indicate a problem with your liver or bile ducts. You should consult with your doctor, who may recommend further tests to establish the cause and devise a suitable treatment plan.

While a high GGT level can indicate a problem with your liver, it doesn't necessarily mean you have a liver disease. Other conditions, such as heart failure, diabetes, and alcohol abuse, can also cause elevated GGT levels. Your doctor will interpret your results in conjunction with your symptoms and other test results.

Yes, certain medications like phenytoin and barbiturates can raise GGT levels. Others, like statins and NSAIDs, may lower them. Always inform your doctor about any medications you're taking.

Abstaining from alcohol, maintaining a healthy weight, eating a balanced diet, and regular exercise can help lower your GGT levels. In cases of liver disease, appropriate treatment should be initiated.

The GGT test serves as an essential tool in diagnosing liver diseases, monitoring their progression, and tracking the response to treatment. It is also a useful indicator of long-term alcohol abuse. By understanding the role of this test and following your doctor's guidelines, you can ensure the most accurate results, leading to an effective treatment plan. Regular check-ups and maintaining a healthy lifestyle can also contribute significantly to preventing and managing liver diseases. Remember, early detection is often the key to successfully handling many health conditions.

GGT (GAMMA GLUTAMYL TRANSPEPTIDASE), SERUM
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