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Lab Test

GAD - 65 Antibody

GAD-65 Antibody test, commonly referred to as Glutamic Acid Decarboxylase-65 Antibody test, is a blood test that measures the level of GAD-65 antibodies in the blood. GAD-65 is an enzyme that plays a crucial role in the nervous system and is involved in the synthesis of a neurotransmitter called gamma-aminobutyric acid (GABA). These antibodies are usually associated with autoimmune conditions that affect the nervous system, including Paraneoplastic Syndrome.

  • Profile Name: GAD - 65 Antibody
  • Sample Type: Blood
  • Preparations Required: No special preparation is required for this test.
  • Report Time: 24 hours

Paraneoplastic Syndrome is a group of rare disorders that are triggered by an abnormal immune response to a tumor or neoplasm. The body produces antibodies to fight the cancer, but these antibodies also attack normal cells, particularly in the nervous system. Detecting GAD-65 antibodies is vital for diagnosing Paraneoplastic Syndrome, managing the condition, and understanding its implications.

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Reporting of the sample at lab
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Frequently Asked Questions

The GAD-65 Antibody test is a blood test that detects the presence of antibodies against the GAD-65 enzyme, which is involved in the production of a neurotransmitter essential for brain function.

The test is performed to help diagnose autoimmune conditions affecting the nervous system, such as Paraneoplastic Syndrome, and certain types of diabetes. It is particularly important in diagnosing disorders where the immune system mistakenly attacks healthy nerve cells.

Paraneoplastic Syndrome refers to a group of rare disorders that are triggered by an abnormal immune response to a tumor. The antibodies produced to combat cancer also attack normal cells, especially in the nervous system.

Individuals exhibiting neurological symptoms such as difficulty in walking, loss of muscle coordination, or memory loss, and are suspected to have an autoimmune disorder or an underlying tumor, may be advised to undergo the GAD-65 Antibody test.

A blood sample is drawn from the arm and sent to a laboratory. The lab tests the blood for the presence of GAD-65 antibodies.

A positive test indicates the presence of GAD-65 antibodies, which may suggest an autoimmune condition affecting the nervous system or Paraneoplastic Syndrome. A negative test may indicate that symptoms are due to another cause.

There is no cure for Paraneoplastic Syndrome, but treatment to manage symptoms and address the underlying cancer can be effective in improving quality of life and controlling the disorder.

Treatment involves addressing the underlying cancer and managing neurological symptoms. This might include immunosuppressive medications, physical therapy, and other supportive treatments.

The test itself is low risk, involving only a standard blood draw. However, misinterpretation of results can occur, and it is essential to have the test performed and interpreted by qualified healthcare professionals.

Yes, medications used to suppress the immune system can have side effects including increased risk of infections, nausea, and liver function abnormalities.

There is no direct evidence that Paraneoplastic Syndrome is hereditary, but some individuals may have a genetic predisposition to developing autoimmune disorders.

Yes, even after successful treatment of the underlying cancer, Paraneoplastic Syndrome can recur.

Without treatment, Paraneoplastic Syndrome can lead to severe neurological problems, disability, and can be life-threatening.

Adopting a healthy lifestyle, including a balanced diet, regular exercise, and abstaining from tobacco and excessive alcohol use, can support the overall health of individuals with Paraneoplastic Syndrome.

If your GAD-65 Antibody test is positive, you should consult a neurologist or oncologist.

Understanding the implications of GAD-65 antibodies is vital for individuals with autoimmune disorders affecting the nervous system, especially Paraneoplastic Syndrome. Timely diagnosis and intervention can significantly improve the management of symptoms and enhance the quality of life for affected individuals. It is essential to follow your doctor's advice and adhere to the recommended treatment plan.

GAD - 65 Antibody (for Paraneoplastic Syndrome)
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