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Lab Test

Free Light Chain Assay (Kappa & Lambda) - Urine

Free Light Chain Assay (Kappa & Lambda) - Urine

Free light chain assay for urine, commonly known as urine free light chain (UFLC) test, measures the free (unbound) kappa and lambda light chains in the urine. Light chains are small proteins produced by plasma cells, a type of white blood cell. Normally, they combine with heavy chains to form immunoglobulins, or antibodies, which play a vital role in the immune response. When there's an overproduction of light chains, they can be released into the blood and eventually appear in the urine as free light chains.


  • Test NameFree Light Chain Assay (Kappa & Lambda) - Urine
  • Sample TypeUrine
  • Preparations RequiredFor this test, a 24-hour urine sample might be needed. You will be given a special container to collect the urine and specific instructions to follow to ensure that the sample is collected correctly.
  • Report Time2 days

The measurement of free light chains in the urine and the ratio of kappa to lambda light chains (kappa:lambda ratio) can provide valuable insights into conditions that affect plasma cells, such as multiple myeloma, a type of bone marrow cancer. This test is particularly useful for monitoring the response to treatment and tracking disease progression in these conditions.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

The Urine Free Light Chain Assay is an important diagnostic tool for conditions that lead to the excessive or abnormal production of light chains, such as multiple myeloma, AL amyloidosis, and related disorders.

No, fasting is not necessary for this test.

The patient may need to collect a 24-hour urine sample. The healthcare provider will provide a special container for collection and instructions on how to collect and store the sample.

This test is usually ordered when a person has symptoms of a plasma cell disorder, such as bone pain, fractures, fatigue, frequent infections, or unexplained weight loss. It can also be performed periodically to monitor disease progression and the efficacy of treatment.

The test gives information about the levels of free kappa and lambda light chains in the urine and the ratio between them. These findings can help in diagnosing certain disorders related to plasma cells and in assessing disease severity and progression.

The frequency of this test depends on the specific clinical situation. For patients receiving treatment for plasma cell disorders, the test may be repeated periodically to monitor the response to therapy.

The only precautions needed for this test relate to the proper collection and storage of the urine sample.

Factors such as kidney disease, certain medications, and some autoimmune conditions can affect the results of the test.

In case of abnormal results, a consultation with a hematologist or an oncologist is recommended.

Elevated levels of free light chains in the urine can indicate a plasma cell disorder, such as multiple myeloma or Waldenstrom macroglobulinemia. However, elevated levels can also occur due to other conditions, such as kidney disease.

The kappa:lambda ratio is the ratio of kappa light chains to lambda light chains. A normal kappa:lambda ratio in the urine is typically between 0.26 and 1.65. An abnormal ratio can suggest a plasma cell disorder, such as multiple myeloma.

The Urine Free Light Chain Assay can detect elevated levels of light chains that may suggest a plasma cell disorder. However, it is not generally used as a screening test for the general population but used in people with symptoms of these disorders or to monitor treatment response in those already diagnosed.

The test involves collecting a urine sample. There should be no pain involved.

The test is reliable when performed and interpreted in conjunction with other relevant tests and clinical findings. However, the results should be considered along with the patient’s history, symptoms, and other diagnostic information.

Yes, kidney disease, certain autoimmune diseases, and infections can affect the test results. It’s crucial to share all relevant health information with your doctor to aid in correct interpretation.

The Urine Free Light Chain Assay provides valuable information about the levels of free kappa and lambda light chains in the urine. This test helps in diagnosing and monitoring disorders related to plasma cells. If you have been asked to take this test, it's essential to understand its importance and discuss any queries or concerns you may have with your doctor.

KAPPA AND LAMBDA (FREE LIGHT CHAIN ASSAY), SERUM
₹ 4000
Schedule Test in Your Available Time
Locations Near You in Hyderabad
  • 4KM from Madhapur
  • 3KM from Banjara Hills
  • 1.9KM from Yusufguda
  • 3KM from Madhura Nagar
  • 5KM from Shaikpet