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FLT3 Gene Mutation ITD Detection with Allele Burden & TKD Mutation(D835)

FLT3 Gene Mutation ITD Detection with Allele Burden & TKD Mutation(D835)

FLT3 Gene Mutation ITD Detection with Allele Burden & TKD Mutation(D835) is a specialized laboratory test performed on a blood or bone marrow sample. The test is used to detect specific types of mutations in the FLT3 gene, a gene that plays a vital role in the production and development of blood cells. These mutations, known as ITD (Internal Tandem Duplication) and D835, are often found in patients with Acute Myeloid Leukemia (AML), a type of blood and bone marrow cancer.


  • Test NameFLT3 Gene Mutation ITD Detection with Allele Burden & TKD Mutation(D835)
  • Sample TypeBlood/Bone Marrow
  • Preparations RequiredNo special preparation is required for this test. The patient can continue with normal diet and medications unless advised otherwise by the doctor.
  • Report Time3 days

This diagnostic test is an essential tool for doctors to help characterize AML more precisely and predict how the disease may progress. The presence of these mutations and the FLT3-ITD allele burden, i.e., the ratio of mutant FLT3 to normal FLT3, can have significant implications for the patient's treatment and prognosis. It is vital to emphasize that this test is generally ordered as part of a larger workup for AML and should not replace routine screenings and health checkups.

Home Sample Collection Process
1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

This test is important as it helps doctors identify the presence of specific FLT3 gene mutations that are commonly found in AML. These mutations can affect how the disease progresses and responds to treatment, making it a valuable tool for guiding treatment decisions.

No, fasting is not required for this test. You can continue your regular diet and medications unless advised otherwise by your doctor.

No special preparation is needed for this test. The sample required for the test is either a blood sample or a bone marrow sample, which will be collected by a healthcare professional.

This test is typically ordered after a diagnosis of AML to identify the specific genetic changes associated with the disease. It may also be ordered at intervals during treatment to monitor response to therapy and detect any potential relapse.

This test detects and quantifies specific mutations (ITD and D835) in the FLT3 gene. It also measures the FLT3-ITD allele burden, which is the ratio of mutant FLT3 to normal FLT3.

The frequency of testing depends on various factors, including the stage of the disease, the treatment approach, and the patient's response to treatment. Your doctor will provide guidance based on your specific circumstances.

Normal results would show no detectable FLT3-ITD or D835 mutations. However, normal ranges can vary among different labs, and your doctor will interpret your results in the context of your overall health and clinical history.

As this test requires a blood or bone marrow sample, there may be minor risks associated with the sample collection process. Ensure to follow all instructions provided by your doctor or the testing facility.

The presence of FLT3 mutations can be affected by various factors, including genetic predisposition and environmental factors. Certain treatments for AML can also influence the FLT3-ITD allele burden.

If the test results show abnormal values, you should consult with a hematologist or oncologist. They specialize in diagnosing and treating blood disorders and cancers, including AML.

You may feel a slight pinch or discomfort when the blood sample is drawn. If a bone marrow sample is needed, the procedure may cause some discomfort, but pain relief options are usually provided.

After the test, your doctor will review the results and discuss the next steps with you. This may include changes in treatment strategy or additional tests to further evaluate your condition.

The test itself has minimal risks and is typically well-tolerated. The risks associated are mainly from the blood draw or bone marrow biopsy, which may include minor bruising, bleeding, or infection at the needle site.

FLT3 gene mutations are not known to vary based on age or gender. However, the prevalence and type of mutations can vary among different populations.

The sample for this test is typically collected through a blood draw from a vein in your arm. If a bone marrow sample is needed, a small amount of bone marrow will be collected through a procedure called a bone marrow biopsy.

Understanding the underlying genetic changes in AML through the FLT3 Gene Mutation ITD Detection with Allele Burden & TKD Mutation(D835) test can significantly impact the management of the disease. By guiding treatment decisions and providing valuable prognostic information, this test can contribute significantly to improving patient outcomes. As with any medical test, it is crucial to discuss with your doctor the purpose of the test, what the results could mean, and the next steps in your care.

FLT3 Gene mutation ITD Detection with allele burden & TKD Mutation(D835)
₹ 6500
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