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Flow Cytometry: Glanzmann's Thrombasthenia Screening

Flow Cytometry: Glanzmann's Thrombasthenia Screening

Flow cytometry is a high-precision, technology-driven process used for characterizing and sorting individual cells from a heterogeneous sample. One critical use of this technology is in Glanzmann's Thrombasthenia screening, a test for a rare genetic disorder that affects platelet function and causes increased bleeding.

Glanzmann's Thrombasthenia (GT) is characterized by the absence or dysfunction of the glycoprotein IIb/IIIa complex on the platelet surface, which is integral to platelet aggregation and the formation of a blood clot. Therefore, the Flow Cytometry GT screening is performed to identify the presence and functioning of this glycoprotein complex, thereby diagnosing or ruling out GT.

The process involves obtaining a small blood sample from the patient and then analyzing the sample using flow cytometry to detect the presence and function of the glycoprotein IIb/IIIa complex.

  • Test NameFlow Cytometry: Glanzmann's Thrombasthenia Screening
  • Sample TypeBlood/bone marrow
  • Preparations RequiredNo specific preparation, such as fasting or medication alteration, is required for the Glanzmann's Thrombasthenia screening test. However, ensure to inform your doctor about any medications or supplements you're currently taking.
  • Report Time2 days

What is the importance of Glanzmann's Thrombasthenia screening?

Glanzmann's Thrombasthenia screening is vital in diagnosing this rare genetic disorder that affects platelet function, leading to increased bleeding. A timely and accurate diagnosis can help manage symptoms and improve a patient's quality of life.

Is fasting necessary before the Glanzmann's Thrombasthenia screening test?

No, fasting is not required before the GT screening test. You can maintain your regular diet and hydration levels unless otherwise instructed by your doctor.

Home Sample Collection Process

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Book your convenient slot
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
Download Reports
Download Reports
Frequently Asked Questions

The GT screening test measures the presence and function of the glycoprotein IIb/IIIa complex on the surface of platelets, a key factor in blood clot formation. If this glycoprotein complex is absent or malfunctioning, it can indicate GT.

The GT screening test is typically conducted once if there's a suspicion of the disorder, based on clinical symptoms or family history. However, your doctor will guide you on the frequency of testing based on your specific situation.

In a normal result, the glycoprotein IIb/IIIa complex is present and functions properly on the surface of platelets. However, 'normal' values can vary based on the specific laboratory and testing methodology. Your doctor will interpret your results in the context of your overall health and specific symptoms.

There are no specific precautions for the GT screening test. However, you should inform your doctor about any current medications or supplements, as they may affect the results.

Certain medications, especially those affecting blood clotting or platelet function, can influence the test results. Non-modifiable factors include genetics, as GT is a hereditary condition.

If your GT screening results are abnormal, you should consult with a hematologist, a doctor specializing in blood disorders. In some cases, you might also need to see a genetic counselor or a specialist in bleeding disorders.

The GT screening test involves a simple blood draw, with risks being minimal and typically limited to minor pain or bruising at the needle site, lightheadedness, and a small risk of infection.

An abnormal GT screening result can suggest the presence of the disorder, but it's not a definitive diagnosis. Additional tests, including genetic testing, might be needed to confirm the diagnosis.

Yes, certain medications, particularly those affecting blood clotting or platelet function, can influence the test results. Always inform your doctor of any medications you're currently taking.

As GT is a genetic disorder, it cannot be prevented. However, with a proper diagnosis and management plan, symptoms can be managed effectively.

Treatment for GT aims to manage symptoms, primarily excessive bleeding. This may involve platelet transfusions, antifibrinolytic drugs, and recombinant factor VIIa. In some cases, a bone marrow transplant may be considered.

Yes, GT can potentially be detected before birth using prenatal genetic testing if there is a known family history of the disorder. Consult with your doctor or a genetic counselor to discuss this option.

While GT can cause serious bleeding complications, it does not typically affect lifespan. With appropriate management and care, individuals with GT can lead normal lives.

Communicating with your doctor is essential in understanding these tests and their implications for your health. If you have any concerns or further questions about the Glanzmann's Thrombasthenia screening test, do not hesitate to discuss them with your doctor. Your health and wellbeing are paramount, and your doctor is there to support you every step of the way.

Flowcytometry - Glanzmann's thrombesthenia screening
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