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FISH: t(8;14) - A Key Marker in Burkitt's Lymphoma Diagnosis

FISH: t(8;14) - A Key Marker in Burkitt's Lymphoma Diagnosis

Fluorescence in situ hybridization, or FISH, is a sophisticated lab technique employed to detect specific genetic changes within cells. FISH targeting t(8;14) is particularly crucial in diagnosing Burkitt's lymphoma, an aggressive type of Non-Hodgkin Lymphoma. This cancer starts in immune cells called B- lymphocytes or B-cells and can manifest itself quickly. It is termed 'Burkitt's lymphoma' after Denis Burkitt, who first described this disease in African children.

One characteristic genetic feature of Burkitt's lymphoma is the translocation between chromosomes 8 and 14, denoted as t(8;14). This translocation involves the movement of genetic material between these chromosomes and is instrumental in the unregulated growth of B-cells, leading to lymphoma.

  • Test NameFISH: t(8;14) - A Key Marker in Burkitt's Lymphoma Diagnosis
  • Sample TypeTissue
  • Preparations RequiredThere are no specific patient preparations needed for the tissue biopsy. However, post-biopsy, it is important to follow the doctor's instructions regarding care of the biopsy site.
  • Report Time7 days

What is the FISH t(8;14) test, and why is it important?

The FISH t(8;14) test is a specialized test that uses fluorescent probes to detect the translocation of genetic material between chromosomes 8 and 14. This translocation is a hallmark of Burkitt's lymphoma and is used in its diagnosis.

How is the tissue sample for the FISH t(8;14) test collected?

A tissue biopsy, typically from a lymph node or other affected tissues, is required for the FISH t(8;14) test. The sample is collected by a doctor using a needle or through a surgical procedure.

Home Sample Collection Process

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Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
Reporting of the sample at lab
Reporting of the sample at lab
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Download Reports
Frequently Asked Questions

A positive FISH t(8;14) test means that the translocation between chromosomes 8 and 14 is present, which is a characteristic feature of Burkitt's lymphoma. This information can be vital for diagnosis and determining an appropriate treatment strategy.

Risks associated with tissue biopsy include pain, infection, and bleeding at the biopsy site. There is also a small risk of damage to surrounding structures during the biopsy.

Symptoms of Burkitt's lymphoma may include swollen lymph nodes, fever, night sweats, unexplained weight loss, and abdominal pain or swelling.

Burkitt's lymphoma is typically treated with intensive chemotherapy. Sometimes, targeted therapies and immunotherapies may be used. The choice of treatment depends on the stage and extent of the disease.

With early diagnosis and aggressive treatment, Burkitt's lymphoma can often be cured, especially in children. However, the prognosis can vary depending on various factors including age, health, and how advanced the disease is at the time of diagnosis.

The translocation t(8;14) involves the MYC gene on chromosome 8 and an immunoglobulin gene on chromosome 14. The MYC gene is involved in cell growth, and its deregulation leads to uncontrolled cell division.

Individuals with symptoms suggestive of Burkitt's lymphoma, such as swollen lymph nodes or abdominal swelling, and those who have been diagnosed with Non-Hodgkin Lymphoma, should consider getting this test as advised by the doctor.

Yes, other less common translocations, such as t(2;8) and t(8;22), can also occur in Burkitt's lymphoma.

Challenges include the aggressive nature of the disease, potential side effects of intensive chemotherapy, and managing the disease in patients with weakened immune systems.

While lifestyle changes alone cannot treat Burkitt's lymphoma, maintaining a healthy lifestyle can help in coping with the treatment and improving overall health.

Burkitt's lymphoma is staged based on how many lymph nodes are affected and whether the disease has spread to other organs.

There is no known genetic predisposition to Burkitt's lymphoma, but certain factors such as Epstein-Barr virus infection and a compromised immune system can increase the risk.

After a diagnosis of Burkitt's lymphoma, it is important to consult with a hematologist-oncologist to discuss treatment options and establish a tailored treatment plan.

The FISH t(8;14) test is a crucial diagnostic tool in Burkitt's lymphoma. Early detection and understanding of the genetic makeup of this aggressive lymphoma can significantly affect the course of treatment and outcome. It is important to work closely with your doctor to make informed decisions about managing and treating this disease.

FISH - t(8;14) - Burkitt's Lymphoma - Tissue
₹ 8900
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