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FISH for TP53 Deletion / del17p

FISH for TP53 Deletion / del17p

FISH for TP53 deletion, also known as del17p, is a diagnostic test that employs Fluorescence In Situ Hybridization (FISH) to detect deletions in the TP53 gene, which is located on the short arm of chromosome 17. TP53 is commonly known as a tumor suppressor gene and is crucial in preventing the development of tumors. The protein encoded by TP53 plays a significant role in DNA repair, cell cycle arrest, and apoptosis. Deletion or mutations in the TP53 gene are linked to numerous cancers, and a deletion specifically in the short arm of chromosome 17 where TP53 resides (17p) is associated with poor prognosis in cancers such as chronic lymphocytic leukemia (CLL) and multiple myeloma.

FISH uses fluorescent probes that bind to the parts of the chromosome of interest, in this case, chromosome 17. When viewed under a special microscope, the fluorescence helps in determining whether there is a deletion in the TP53 gene. The presence or absence of fluorescence indicates the status of the TP53 gene.

  • Test NameFISH for TP53 Deletion / del17p
  • Sample TypeBlood or Bone Marrow
  • Preparations RequiredNo fasting or special preparation is required before the test.
  • Report Time5 days
What is FISH for TP53 deletion?

FISH for TP53 deletion is a diagnostic test that uses fluorescent probes to detect deletions in the TP53 gene located on chromosome 17. This gene is vital in preventing tumor formation, and its deletion is associated with various cancers.

Why is FISH for TP53 deletion important?

The deletion of TP53 is associated with aggressive cancer behavior and resistance to certain treatments. Identifying this deletion helps doctors in determining prognosis and making decisions about the most effective treatment strategies.

Home Sample Collection Process

1
Book your convenient slot
Book your convenient slot
2
Sample Collection by Phlebotomist
Sample Collection by Phlebotomist
3
Reporting of the sample at lab
Reporting of the sample at lab
4
Download Reports
Download Reports
Frequently Asked Questions

Individuals diagnosed with chronic lymphocytic leukemia, multiple myeloma, or other cancers where TP53 deletion is suspected to be a factor, should consider getting this test. It is usually recommended by an oncologist.

A blood sample or bone marrow sample is obtained from the patient. The sample is then treated with fluorescent probes that bind to the TP53 gene. The presence or absence of fluorescence under a microscope indicates whether there is a deletion in the TP53 gene.

A deletion in the TP53 gene means that one copy of this gene is missing. This can lead to a decreased production of the TP53 protein, which is essential for preventing the growth of cancer cells. TP53 deletion is associated with aggressive cancer and resistance to certain treatments.

Your doctor will use the information to determine the most effective treatment plan for your condition. TP53 deletion may mean that certain treatments are less likely to be effective, and alternative strategies may need to be considered.

Yes, in some cancers, such as chronic lymphocytic leukemia, a deletion in TP53 is associated with a poorer prognosis. This information can be used to guide treatment decisions and to counsel patients regarding the likely course of their disease.

No, the test does not require any special preparation, such as fasting.

The risks associated with FISH for TP53 deletion are minimal and are mainly related to the collection of the blood or bone marrow sample.

Technical issues with the test, or issues with the sample, can sometimes affect the results. It is also possible that tumor heterogeneity may affect interpretation.

Yes, other tests such as PCR and next-generation sequencing can also be used to detect abnormalities in the TP53 gene.

In chronic lymphocytic leukemia, TP53 deletion is associated with resistance to chemotherapy and a more aggressive course of the disease.

While lifestyle factors can influence the risk of developing cancer, TP53 deletion is a genetic event that is not influenced by lifestyle.

If your test results show TP53 deletion, it is important to discuss them with your doctor to understand what they mean for your treatment options and prognosis.

If the test shows TP53 deletion, it is advisable to consult an oncologist who specializes in the type of cancer you have been diagnosed with.

The FISH for TP53 deletion is an invaluable test in the management of certain cancers. It offers insights into the genetic makeup of the tumor, which can be critical in decision-making regarding treatment. Understanding whether TP53 is deleted helps both patients and doctors make informed choices about how to proceed with management and treatment of the condition. Through this test, personalized treatment plans that cater to the specifics of the genetic alterations in each patient can be developed. This test is an example of how personalized medicine is shaping the future of cancer care.

FISH for TP53 deletion / del17p
₹ 4300
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