FISH for TP53 Deletion-del17p - Price, Normal Range | Sprint Diagnostics Hyderabad

Patient Preparing : No fasting or special preparation is required before the test.

₹ 4300


FISH for TP53 deletion, also known as del17p, is a diagnostic test that employs Fluorescence In Situ Hybridization (FISH) to detect deletions in the TP53 gene, which is located on the short arm of chromosome 17. TP53 is commonly known as a tumor suppressor gene and is crucial in preventing the development of tumors. The protein encoded by TP53 plays a significant role in DNA repair, cell cycle arrest, and apoptosis. Deletion or mutations in the TP53 gene are linked to numerous cancers, and a deletion specifically in the short arm of chromosome 17 where TP53 resides (17p) is associated with poor prognosis in cancers such as chronic lymphocytic leukemia (CLL) and multiple myeloma.

FISH uses fluorescent probes that bind to the parts of the chromosome of interest, in this case, chromosome 17. When viewed under a special microscope, the fluorescence helps in determining whether there is a deletion in the TP53 gene. The presence or absence of fluorescence indicates the status of the TP53 gene.

Test Name FISH for TP53 Deletion / del17p
Sample Type Blood or Bone Marrow
Preparations Required No fasting or special preparation is required before the test.
Report Time 5 days
Price in Hyderabad ₹ 4300

What is FISH for TP53 deletion?

FISH for TP53 deletion is a diagnostic test that uses fluorescent probes to detect deletions in the TP53 gene located on chromosome 17. This gene is vital in preventing tumor formation, and its deletion is associated with various cancers.

Why is FISH for TP53 deletion important?

The deletion of TP53 is associated with aggressive cancer behavior and resistance to certain treatments. Identifying this deletion helps doctors in determining prognosis and making decisions about the most effective treatment strategies.

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Who should consider getting a FISH for TP53 deletion test?

Individuals diagnosed with chronic lymphocytic leukemia, multiple myeloma, or other cancers where TP53 deletion is suspected to be a factor, should consider getting this test. It is usually recommended by an oncologist.

How is the FISH for TP53 deletion test performed?

A blood sample or bone marrow sample is obtained from the patient. The sample is then treated with fluorescent probes that bind to the TP53 gene. The presence or absence of fluorescence under a microscope indicates whether there is a deletion in the TP53 gene.

What does it mean if there is a deletion in the TP53 gene?

A deletion in the TP53 gene means that one copy of this gene is missing. This can lead to a decreased production of the TP53 protein, which is essential for preventing the growth of cancer cells. TP53 deletion is associated with aggressive cancer and resistance to certain treatments.

How will the results of this test affect my treatment?

Your doctor will use the information to determine the most effective treatment plan for your condition. TP53 deletion may mean that certain treatments are less likely to be effective, and alternative strategies may need to be considered.

Can FISH for TP53 deletion predict prognosis in cancer?

Yes, in some cancers, such as chronic lymphocytic leukemia, a deletion in TP53 is associated with a poorer prognosis. This information can be used to guide treatment decisions and to counsel patients regarding the likely course of their disease.

Does FISH for TP53 deletion require any special preparation?

No, the test does not require any special preparation, such as fasting.

Are there risks associated with this test?

The risks associated with FISH for TP53 deletion are minimal and are mainly related to the collection of the blood or bone marrow sample.

Can other factors affect the results of this test?

Technical issues with the test, or issues with the sample, can sometimes affect the results. It is also possible that tumor heterogeneity may affect interpretation.

11. Is there an alternative to the FISH for TP53 deletion test?

Yes, other tests such as PCR and next-generation sequencing can also be used to detect abnormalities in the TP53 gene.

What are the implications of a TP53 deletion in chronic lymphocytic leukemia?

In chronic lymphocytic leukemia, TP53 deletion is associated with resistance to chemotherapy and a more aggressive course of the disease.

Can lifestyle factors influence TP53 deletion?

While lifestyle factors can influence the risk of developing cancer, TP53 deletion is a genetic event that is not influenced by lifestyle.

What should I do if my test results show TP53 deletion?

If your test results show TP53 deletion, it is important to discuss them with your doctor to understand what they mean for your treatment options and prognosis.

Which doctor should I consult if the test shows TP53 deletion?

If the test shows TP53 deletion, it is advisable to consult an oncologist who specializes in the type of cancer you have been diagnosed with.

The FISH for TP53 deletion is an invaluable test in the management of certain cancers. It offers insights into the genetic makeup of the tumor, which can be critical in decision-making regarding treatment. Understanding whether TP53 is deleted helps both patients and doctors make informed choices about how to proceed with management and treatment of the condition. Through this test, personalized treatment plans that cater to the specifics of the genetic alterations in each patient can be developed. This test is an example of how personalized medicine is shaping the future of cancer care.

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